Browse All Grants
606,025 grants found
Showing 28,221 – 28,240 of 606,025 grants
Structure-based antisense therapeutics targeting dystrophin exons 44 and 45 for Duchenne Muscular Dystrophy
Project Summary Duchenne muscular dystrophy (DMD) is a lethal pediatric neuromuscular disorder that affects 1/5000 boys globally. This rare disease is caused by mutations in the ge...
Using Large Language Models to identify social determinants of health to enhance healthcare services and equity
PROJECT SUMMARY/ABSTRACT Social determinants of health are known to have a significant impact on patient outcomes. However, controversies exist on how to best capture this informat...
Optimizing an integrated passive body heating and behavioral intervention for insomnia
PROJECT SUMMARY/ABSTRACTInsomnia disorder is a common and consequential mental health problem, with prevalence estimates at approximately 10%. The American College of Physicians re...
Building Mood State Classifiers to Inform Deep Brain Stimulation (DBS) of Treatment-Resistant Bipolar Depression
Bipolar Disorder (BD) is a recurrent neuropsychiatric disorder characterized by wide fluctuations in mood, energy, and activity.Although the hallmark of BD is mania in BD-I (hypoma...
Heat therapy to improve functional performance in Heart Failure with Preserved Ejection Fraction
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) is a debilitating disease with high morbidity, mortality and health care expenditures. Impaired physical capa...
Deep Learning-based Diagnosis of Retinopathy of Prematurity
Project Summary Retinopathy of prematurity (ROP) is a leading yet largely preventable cause of childhood blindness globally. There is an unmet need for timely and consistent diagno...
Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons
Tendinopathies are common injuries that typically result from accumulation of sub-rupture fatigue damage. We have developed an in vivo model of sub-rupture fatigue damage accumulat...
Clinical assessment of radiotherapy-induced vaginal toxicity with multiparametric ultrasound imaging
PROJECT SUMMARY/ABSTRACT Pelvic radiotherapy is the standard of care for numerous gynecological and anorectal cancers affecting women. Post-operative intravaginal brachytherapy (IV...
How cerebrospinal fluid (CSF) potassium supports brain development and activity
PROJECT SUMMARY/ ABSTRACT The brain and spinal cord are filled with and surrounded by a complex fluid, the cerebrospinal fluid (CSF). CSF directly contacts brain progenitors to act...
Mechanisms required to compartmentalize the stem cell niche during organogenesis.
Project Summary/Abstract: Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks often requires intimate association between stem cells and thei...
Peptide cues in the environment regulate bacterial dormancy
PROJECT SUMMARY Bacterial cells communicate through the language of molecular cues that are released into the environment and detected by cells in nearby communities. While prevale...
Probing the potential role of the Rieske protein in superoxide formation in Complex III
Abstract Reactive Oxygen Species include molecules such as superoxide, peroxide and hydroxyl radicals. High levels of these molecules have been shown to lead to diseases such as he...
MitoNEET is a Regulator of the Cellular Thiol State in Health and Disease
PROJECT SUMMARY MitoNEET is a druggable target, with recognized roles in type-2 diabetes, cancer, and Parkinson’s Disease. The redox-active [2Fe-2S] cluster of mitoNEET, localized...
Investigating common luminophore in protein-metal nano-complexes
ABSTRACT Biomaterials with luminescence in the visible wavelengths are the indispensable tool of biological research today. A new class of luminescent protein material, protein-gol...
A design strategy to quantify unconjugated Nedd8 using genetically encoded sensors.
PROJECT SUMMARY/ABSTRACT Genetically encoded sensors that can detect and quantify proteins and other ligands are useful tools for studies of target dynamics and biomedical applicat...
Integrated single cell and spatial mapping of habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure.
PROJECT SUMMARY The national opioid epidemic is a significant public health crisis requiring accelerated efforts to translate mechanistic studies into therapeutic developments. Sub...
Metabolism and Epigenetic Regulation are Couples in Transdifferentiation and Vascular Regeneration
Abstract We discovered that nuclear reprogramming of somatic cells to a different somatic cell lineage, or induced pluripotent stem cells, requires activation of inflammatory signa...
The Effects of Cannabidiol on the Driving Performance of Healthy Adults
PROJECT SUMMARY Cannabidiol (CBD) is now a legal, widely consumed, substance in the United States, but research regarding CBD’s effects in healthy populations remains sparse. Altho...
BD FACSDiscover S8 Image-Enabled Spectral Cell Sorter
PROJECT SUMMARY/ABSTRACT Funding is requested for the Becton Dickinson FACSDiscover S8, a high-end next-generation cell sorter with unprecedented capabilities. The FACSDiscover S8...
Leica Stellaris 8 Falcon confocal microscope
SUMMARY In response to the expanding need for multiplexed high-resolution imaging in biomedical research conducted at Massachusetts General Hospital, we are requesting funds to pur...