Browse All Grants
606,025 grants found
Showing 28,121 – 28,140 of 606,025 grants
NIA Academic Leadership Career Award
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease is a national public health issue. Black American and Hispanic older adults are significantly more likely to have Alzheimer’s disease a...
Developing a novel human laboratory paradigm for AUD medication screening: Modeling the ability to resist drinking and heavy drinking
ABSTRACT Use of human laboratory analogues of drinking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on drinking, with the result...
Unraveling tissue level regulation of thyroid hormone and its role in sex differences in cardiovascular health
PROJECT SUMMARY Cardiovascular disease (CVD) is the leading global cause of death, claiming approximately 17.9 million lives annually. Women face a significantly higher risk of hea...
Neural Mechanism of Impaired Satiation After Magel2 Mutation
Project summary Satiation is an important aspect of interoception that translates gut signals, such as cholecystokinin (CCK), into eating suppression. Insatiable appetite is associ...
Bridging the gap between genetic variants and radiomic phenotypes via genomic large language models
PROJECT SUMMARY/ABSTRACT One of the fundamental challenges in modern biology is to decode the functionalities of human genome sequence. Over the past decade, genome-wide associatio...
A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer
7.0 Project Summary/Abstract Up to 70% of patients with advanced cancer experience significant levels of FOP. FOP is the most common psychosocial concern among GYN and other cancer...
Mechanisms and Genetic Consequences of Break-Induced Replication.
PROJECT SUMMARY During normal cell metabolism, exogenous and endogenous factors cause double-strand DNA breaks (DSBs) that result in genome instability. DSB repair is critical for...
Inside Condensates: Bridging molecular structure and condensate material properties through simulation
PROJECT SUMMARY Proteins and nucleic acids within cells assemble into membraneless compartments referred to as biomolecular condensates. Condensates display a range of material pro...
Investigating the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells
PROJECT SUMMARY Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases, but low HSC numbers and their tendency to differentiate in vitro are l...
A randomized comparative effectiveness trial of nicotine pouches for cigarette substitution: A question of public health
PROJECT SUMMARY Commercial cigarette smoking is a modifiable risk factor implicated in one-third of all cancer deaths. Nicotine is the chief addictive agent causing sustained smoki...
Regulation of mitochondrial signaling by protein AMPylation
ABSTRACT Mitochondria are essential organelles that serve as the cellular hub for metabolism, ATP production, and redox signaling. We identified a novel mechanism of signaling in t...
Role of human-specific haplotype diversity on cell fate commitment
Project summary The primary focus of research in my laboratory centers on unraveling the causal relationship between common genetic variants in humans and susceptibility to complex...
Creating tools to make experimental biochemistry accessible to people with blindness
Project summary. People with blindness and low vision (BLV) experience systemic exclusion from biomedical science because the tools of experimental science—and the data they produc...
Culturally and Structurally Adapted Chronic Pain Self-Management Program for Young Black Adults
PROJECT SUMMARYPain disparities for U.S. Black adults are well documented, but prevention and treatment efforts rarely target young adults who make up 39% of the population. Our kn...
AI-Driven Frailty Assessment and Molecular Correlation: A Multimodal Mentorship Initiative
Dr. Peter Abadir is an active Geriatrician and associate professor of Medicine, Electrical, and Computer Engi- neering at Johns Hopkins University (JHU). He has put forth this K24...
Probing protein structure and aggregation in complex environments with 2D IR spectroscopy
The goal of our proposed research program is to develop new spectroscopic methods capable of providing enhanced insight into protein structure and dynamics within complex environme...
Mutant KRAS targeted vaccines for the interception of pancreatic cancer development
ABSTRACT The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing, and despite the use of conventional therapies, including immune checkpoint inhibitors, 5–year survi...
The importance of failure in science education: Interventions to promote STEM motivation through failure
Project Summary/Abstract To meet national needs of the future, the United States must increase the production of biomedical college graduates and draw on a broader range of talent,...
Role of clonal somatic mutations in microglia and Alzheimer’s disease
Project Summary/Abstract Alzheimer’s disease (AD) and other neurodegenerative diseases are characterized by age-related onset and progressive neuronal loss. Neuroinflammation media...
Unraveling the molecular origins of chronic parenchymal lung diseases
PROJECT SUMMARY: Single-cell genomic studies have transformed our understanding of the cellular organization and plasticity of the human lung, providing substantial insights into m...