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606,025 grants found
Showing 28,101 – 28,120 of 606,025 grants
Causes and consequences of genomic instability in myelodysplasia
PROJECT SUMMARY/ABSTRACT Myelodysplastic syndromes (MDS) are a group of age-related marrow failure disorders characterized by cytopenia and anemia. It is estimated that 10,000 new...
Nanoparticles to reprogram innate immune cells and disrupt the metastatic niche
Summary. Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that is treated with neo-adjuvant therapy that targets both the primary tumor and systemic dise...
Molecular mechanisms of developmental reprogramming in colorectal cancer
Colorectal cancer (CRC) is growing global threat, especially among younger adults. Impaired differentiation is a critical mechanism by which CRC cells unlock cell state plasticity;...
Estimating Impacts of Social Safety Net Generosity on Neglect and Physical Abuse in Young Children
Summary Approximately 1 in 3 children in the US experience neglect and/or abuse (“maltreatment”) before they turn 18-years old, with marginalized racial and ethnic communities and...
Durability of a gene editing therapy that restores dystrophin in a humanized mouse model of Duchenne muscular dystrophy
Project Summary Gene editing offers significant advantages for treating rare diseases since it edits the patient’s own DNA. Thus, the normal regulatory environment of the gene is m...
Randomized clinical trial of a telemedicine-mHealth symptom cluster intervention for advanced cancer patients: Increasing access in underserved rural communities
Abstract People with advanced cancer experience a greater frequency and severity of physical and psychological symptoms, ranking sleep difficulties, worry-anxiety, depression, and...
Developing multiparametric fluorescence microscopy to connect metabolism with cellular manipulations
Project Summary: Correlating metabolic changes with external or internal stimuli and cellular manipulations in high spatial detail is important for understanding causation and corr...
Flow Of Gene Expression Across Mitochondrial Condensates
Project Summary/Abstract: Phase transitions are emerging as a fundamental organizational principle for gene regulation. Transcription is organized into diverse higher-order structu...
Spatio-temporal cellular dynamics regulating differential healing outcomes
Project Summary / Abstract: Healthy individuals have a tremendous intrinsic ability to heal after injury. Wound repair involves complex and coordinated actions of various cell type...
Molecular Mechanisms of VMAT2 Function
Abstract Monoaminergic signaling controls many aspects of human physiology, including autonomic responses, movement, and emotion. The vesicular monoamine transporter 2 (VMAT2) is t...
Measuring What Matters-Patient Centered Outcome Measures of Goal-Directed Care for People with Serious Mental Illness
This proposal, submitted in response to NIMH RFA-MH-23-265, Developing Measures to Advance Quality in Mental Health Care Services, aims to develop Person-Centered Outcome measures...
Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use
PROJECT ABSTRACT Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use of opioid substances, including prescribed pharmaceuticals...
A Validation Study of Satellite-based Measure of Artificial Light at Night for its Application in Epidemiological Research
PROJECT SUMMARY Artificial light at night (ALAN) is an emerging environmental. Growing research has linked higher ALAN exposures to a broad range of diseases, including cardiometab...
Quantitative Team Science (QuanTS) Program
PROJECT SUMMARY As the demand for data-intensive, interdisciplinary research increases, so does the demand for quantitative scientists who excel not only at working with data but a...
Randomized Trial of Corticosteroids for Post-Extubation Aspiration
PROJECT SUMMARY/ABSTRACT Dysphagia and aspiration are significant health problems associated with aging. By 2030, the United States elderly population is anticipated to exceed 72 m...
Inflammatory subtypes and multi-omic determinants of early life infection risk
PROJECT SUMMARY Nicole Prince, PhD is a biochemist with expertise in applying molecular epidemiology analytic approaches to understand complex diseases. Her overarching career goal...
Discovery of novel disease modifying therapy for the prevention and treatment of glaucoma
R21 Grant Proposal Discovery of disease modifying therapy for the prevention and treatment of glaucoma Abbot F. Clark, PhD and David P. Siderovski, PhD Pharmacology & Neuroscie...
Multi-site, double-blind, randomized-controlled, efficacy trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for depression symptoms in older adults with high suicide risk
ABSTRACT: Older adults with moderate-to-severe depression symptoms (i.e., PHQ-9 scores ≥ 10) plus active suicidal ideation (SI) and/or a history of attempt are at high risk for sui...
Sample-to-answer HPV DNA nucleic acid test for cervical cancer screening in Mozambique
PROJECT SUMMARY / ABSTRACT Cervical cancer is the 4th most common female cancer and cause of cancer-related mortality worldwide, despite being preventable through HPV (human papill...
Utilizing spatially-informed cell-specific multicellular genome-scale metabolic models to unveil the mechanisms that regulate the decline of the ovarian reserve
PROJECT SUMMARY This proposal seeks to understand and predict the onset and duration of the menopause transition using a Systems Metabolic approach. Menopause, which is the complet...