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606,025 grants found
Showing 28,081 – 28,100 of 606,025 grants
Developing a CRISPR-free mammalian recombineering system
Developing a CRISPR-free mammalian recombineering system Project Summary / Abstract The ability to manipulate large segments of DNA in mammalian cells is essential for research and...
Development of Oral KCC2 Potentiator AXN-027 as a Novel Anti-Epileptic Drug for Mesial Temporal Lobe Epilepsy
Development of oral KCC2 potentiator AXN-027 as a novel anti-epileptic drug for mesial temporal lobe epilepsy Abstract: Patients with mesial temporal lobe epilepsy (mTLE) have spon...
Developing a Pathway for Preparing Underrepresented Minority Students for a Career in Otolaryngology and Communication Sciences
ABSTRACT The Black or African American population continues to face barriers in workforce representation in the fields of Otolaryngology and Communication Sciences despite multiple...
Enhancing Visual Accessibility of Indoor Spaces
Project Summary/Abstract The visual accessibility of a space refers to the effectiveness with which vision can be used to travel safely and pursue intended activities in the space....
Implementing decision support for long term care
Abstract: Poor care quality and safety in long-term care (LTC) facilities (i.e., nursing homes, assisted living)— particularly for persons living with dementia (PLWD)—leads to prev...
Vertically Integrated Approach to Design a Biologically and Mechanically Optimized Vascular Conduit for Dialysis Vascular Access
ABSTRACT Dialysis vascular access (arteriovenous fistulae [AVF] and arteriovenous grafts [AVG]) is the Lifeline for the 500,000+ patients on hemodialysis in the United States (3mil...
A hybrid effectiveness-implementation trial to integrate precision skin cancer risk feedback in federally qualified health centers
ABSTRACT The incidence of skin cancer has increased over the past several decades. Limiting exposure to ultraviolet radiation and engaging in early detection can reduce skin cancer...
Interdisciplinary research training in maternal and childhood pain
PROJECT SUMMARY/ABSTRACT There is considerable societal need to better understand neurobiological mechanisms, psychosocial processes, treatments, preventions, and policy in child a...
Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking: A Randomized Controlled Trial
PROJECT SUMMARY Tobacco use remains the leading preventable cause of death and illness in our society and causes 30% of cancer deaths. Despite this, 28.3 million US adults smoke. M...
High-dimensional chemical targeting of multiple neuron types to regulate energy balance
Summary Recent drugs for treating obesity and diabetes, while promising, have major side effects. For example, drugs that reduce food intake by targeting the melanocortin-4 recepto...
Implementing depression and adherence treatment in S. Africa HIV care
PROJECT SUMMARY Background: Evidence-based treatments for depression and treatment adherence in persons with HIV (PWH) are not reaching a sufficient number of PWH who need them, an...
Personalized genomics signal deconvolution to improve cell-type level inference
Abstract: The real-world clinical bulk sequencing samples contain mosaics of various cell types. The recent success of signal deconvolution methods demonstrated that properly accou...
Georgia Science Education Initiative NCI YES (GA-YES)
Project Summary/Abstract While the racial and ethnic diversity of the US has increased over time, the diversity of those involved in cancer and biomedical research has not reflecte...
Future Deaf Scientists Program at Wilmot Cancer Institute
PROJECT SUMMARY /ABSTRACT People with disabilities – especially deaf and hard-of-hearing individuals – continue to be underrepresented in STEM graduate programs, health science pro...
Understanding the role of Hdacs in zebrafish craniofacial development
One third of all birth defects are associated with craniofacial malformation including lack of suture closure, cleft palate, or failure of skeletal formation. Progress in understan...
A Systems Approach for Elucidating Genetic Determinants of Human Brown Adipose Tissue Function
Obesity directly contributes to comorbid diseases which account for the leading causes of morbidity and mortality in much of the world.Although functional brown adipose tissue (BAT...
Expanding the design space of polyelectrolyte complex micelles
PROJECT SUMMARY Polyelectrolyte complex micelles (PCMs) are a unique class of self-assembled nanoparticles that form with a core of associated polycations and polyanions surrounded...
Discovery of Chemical Factors in the Gut Microbiome that Control Alpha-Synuclein Aggregation in Parkinson's Disease
PROJECT SUMMARY. Accumulation of α-synuclein (α-syn) protein aggregates in brain neurons is thought to play a causal role in Parkinson's disease (PD). There is mounting eviden...
Low Energy Availability (LEA), Nutritional Deficiencies and Hypertension in Black Division I Athletes
Title: Low Energy Availability (LEA), Nutrient Deficiencies, and Hypertension in Black Division I Athletes SPECIFIC AIMS: The International Olympic Committee on Sports Nutrition (I...
Neural circuit mechanisms for a mirror-induced self-directed behavior
PROJECT SUMMARY The ability to remember one's own features and monitor the current states is a fundamental for self- recognition. To experimentally demonstrate the visual self...