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606,025 grants found
Showing 27,841 – 27,860 of 606,025 grants
Dissecting the immunomodulatory effects of NK cells on immune responses to cancer
PROJECT SUMMARY Current immunotherapies, such as anti-PD-1 immunotherapy, have low objective responses in patients, necessitating the development of novel therapies that boost immu...
A 400MHz NMR Spectrometer
A 400 MHz NMR Spectrometer The Analytical Resources Core (ARC) at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer to expand the capacity of...
Investigating the role of YAP1 in blood cell specification
PROJECT SUMMARY/ABSTRACT Birth defects are the primary cause of infant mortality in the United States, affecting twenty percent of total infant deaths. Thus, comprehensive insights...
Fertility Among Women with Chronic Health Conditions: A Mixed Methods Study
Project Summary/Abstract Chronic health conditions—diseases that require ongoing medical attention—affect 1 in 5 people of reproductive age in the United States.1 Although these co...
Interrogation of non-canonical roles of VGSCs in neurodevelopmental epilepsy
PROJECT SUMMARY Voltage-gated sodium channels (VGSCs) are transmembrane proteins with well-established roles in neuronal physiology, including action potential initiation and propa...
Improving statistical power for human structural and functional connectomes
PROJECT SUMMARY The field of human neuroimaging has long been suffering from a problem of low power, in which low signal-to- noise ratio, multiple comparisons, and small sample siz...
How does the brain accumulate cognitive maps?
Project Summary Across our lifetimes we have an infinite number of experiences that are stored in our memories. As we age our capacity to reuse this information to influence our fu...
Listener training for improved intelligibility of people with Parkinson's disease
PROJECT SUMMARY/ABSTRACT People with dysarthria due to Parkinson's disease (PD) frequently present with reduced intelligibility, which can have significant consequences, inclu...
Regulation of viral-bacterial co-infections by immunometabolism
SUMMARY/ABSTRACT Pseudomonas aeruginosa is a major respiratory pathogen in the pathogenesis of Cystic Fibrosis (CF) and the ineffective immune response to this pathogen is thought...
Next Generation OAEs
Project Summary/Abstract Distortion product otoacoustic emissions (DPOAE) are grossly underutilized in clinical applications. Yet the need for early and accurate diagnosis as well...
Technology for MR brain monitoring
7. Project Summary/Abstract: Technology for MR brain monitoring Magnetic Resonance Imaging (MRI) has been the undisputed standard of care for the detection and diagnosis of neurolo...
Effect of mutant HTT on the development and maturation of astrocytes
Project Summary / Abstract: Astrocytes are known to be dysfunctional in Huntington’s disease (HD); however, further research is needed to understand how these star-like cells devel...
Molecular and Cellular Mechanisms of Mutant ASXL1-driven Clonal Hematopoiesis
PROJECT SUMMARY/ABSTRACT Clonal hematopoiesis of indeterminate potential (CHIP) broadly describes the clonal expansion of blood cells derived from hematopoietic stem cells (HSCs) w...
Molecular and cellular characterization of congenital hydrocephalus
PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is the leading cause for brain surgery and is associated with marked neurodevelopmental disability. CH is traditionally consi...
Chip phosphorylation stimulates the degradation of mutant transthyretin to attenuate cardiac amyloidosis
PROJECT SUMMARY/ABSTRACT Cardiac amyloidosis can be caused by a mutation in transthyretin (TTR) (e.g. valine 122 to isoleucine, VI) [ATTR- CM] that will aggregate when taken up by...
Automated Multi-run Carbon-11 Radiosynthesis System
Project Summary This application requests funding to support the purchase of a new PET radiochemistry synthesis system for the production of investigational carbon-11 radiotracers....
UW PET/CT Acquisition
PROJECT SUMMARY/ABSTRACT The objective of this proposal is to purchase a state-of-the-art microPET/CT small animal imaging scanner for the University of Wisconsin Small Animal Imag...
Neurophysiology of movement transitions in Parkinson's disease with freezing of gait
Abstract Freezing of gait (FOG) is characterized by episodes during which an individual is unable to step, despite intending to do so, and is a common cause of falls, decreased mob...
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
Project Summary/Abstract When the API Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial (NCT01998841) was announced in 2012, it launched a new era in AD prevention...
Mathematical modeling of selective vulnerability of genes, cells and network in mouse tauopathy
Project Summary Alzheimer's disease (AD) is a heterogeneous, multifactorial disease that selectively affects certain regions of the brain, e.g. locus coeruleus, entorhinal and...