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606,025 grants found
Showing 27,861 – 27,880 of 606,025 grants
Elucidating the role of CHI3L1/YKL-40 in Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT Chitinase-3-like protein 1 (CHI3L1/YKL-40) is a well-known biomarker for the early detection of neuroinflammation and Alzheimer’s disease (AD). It acts as...
Integrating multi-omics data to understand asthma heterogeneity and endotypes
Summary/Abstract Asthma is a common chronic respiratory disease and is considered to be an umbrella diagnosis for several sub-diseases with distinct biological pathways and clinica...
Alzheimer's Special Care Units in Nursing Homes: Racial and Ethnic Disparities, Resident Outcomes, and State Policies
PROJECT SUMMARY/ABSTRACT Alzheimer's special care units (SCUs) are a promising care model for nursing home residents with Alzheimer's Disease & Related Dementias (ADR...
A Single-Arm Pilot trial for Mitigating Relapse of Severe Problem Behavior
Project Summary/Abstract Over 2 million people in the United States with intellectual and developmental disabilities (IDD) engage in some form of SPB (self-injury, aggression; Croc...
Investigating the mechanism of K17-mediated immunosuppression in papillomavirus-induced cancers
PROJECT SUMMARY/ABSTRACT My long-term career goal is to become an independent scientist in an academic research institution. My research interest focuses on investigating novel mol...
Maternal health interventions in California hospitals: Understanding approaches & implementation to advance equity
PROJECT SUMMARY/ABSTRACT This is a Mentored Research Scientist Career Development Award (K01) award for Dr. Sarah B. Garrett, PhD, a medical sociologist and Assistant Professor at...
Symposium to Advance Total Worker Health
PROJECT SUMMARY Our primary objectives for the Total Worker Health® education planning workshop (workshop) and the 4th International Symposium to Advance Total Worker Health® (Symp...
Regulation of mechanically activated Piezo2 ion channels by membrane lipids
ABSTRACT Piezo2 is a non-selective Ca2+-permeable cation channel activated by mechanical force. It is expressed in peripheral sensory neurons of the dorsal root ganglia (DRG) and i...
Translational analysis of a novel intervention to promote healthy aging.
Project Summary Advancing age is associated with an increased risk of type 2 diabetes, which is exacerbated by the high prevalence of obesity in the aged. These disorders are risk...
Impacting Inflammation through Mechanistic Target of Rapamycin (imTOR)
Inflammatory diseases limit healthspan, defined as the length of one’s life spent in good health. We propose an ancillary study to an NIA-funded trial U01AG076941 (EVERLAST) that w...
Mechanistic modeling to link scRNAseq data to physiological predictions
PROJECT SUMMARY The overall goal of this R21 application is to develop methods to predict how the presence of multiple subtypes of ventricular cardiomyocytes influences cardiac fun...
Understanding the functional role of fibroid subtype mutations for drug discovery
PROJECT SUMMARY/ABSTRACT Research Project: Uterine fibroids are the most common benign tumors in women of reproductive age. The economic impact of symptomatic uterine fibroids in t...
Mechanotransduction regulation of cellular metabolism in pulmonary fibrosis
PROJECT SUMMARY Idiopathic Pulmonary Fibrosis (IPF) is a progressive scarring disease with limited therapeutic options. Fibrotic lung diseases are characterized by an accumulation...
Practices of Foster Caregivers and the Developmental Outcomes of Youth in Foster Care: A Multi-Method Investigation
Project Summary Youth in foster care have unique experiences and significantly higher trauma load which greatly increase their risk for a range of negative social, behavioral, acad...
Reducing obesity through play: A randomized control trial
1 ABSTRACT 2 Obesity and related chronic diseases that result from years of poor diet and physical activity (PA) may be 3 prevented by wellness programs for toddlers (18–36 months)...
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis
PROJECT SUMMARY Mitral valve prolapse (MVP), a condition affecting 2-3% of the general populace, is typified by irregular thickening of valve leaflets. The histopathological modifi...
Unraveling the Ciliary Driver of Polycystic Kidney Disease
Project Summary/Abstract Polycystic kidney disease (PKD) is the leading genetic cause of renal failure, affecting an estimated 500,000 Americans. There is currently no cure for the...
Characterization of colonization and protein secretion by Pichia pastoris in the gastrointestinal tract of mice
PROJECT SUMMARY Rising expense associated with stability and delivery are significant obstacles for using therapeutic proteins to treat diseases. To resolve these issues, we propos...
Functional Convergence at the Host-Virus Interface
Project summary Viruses and the organisms they infect impose strong reciprocal selective pressure on each other. This is particularly pronounced at protein-protein interfaces betwe...
Deciphering Transcription Factor-Coregulator Interactions through Innovative Tools
ABSTRACT Transcription factors and their coregulators are pivotal in directing gene regulation, cellular differentiation, and disease progression. Acting as molecular switches, the...