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606,025 grants found
Showing 27,821 – 27,840 of 606,025 grants
Developing a Supportive Research Administration Ecosystem
Project Summary/Abstract Aga Khan University (AKU) is a private, international, not-for-profit institution whose network of medical centers and hospitals throughout East Africa and...
Collaborative Care to Improve Resilience and Quality of Life among Youth with Non-malignant Blood Disorders
Project Abstract Adolescents and Young Adults (AYAs) with blood disorders are at high risk of poor physical, emotional, and social quality of life. On average, they suffer from sev...
PROVIDENT: Prepositioning Optimized Strategies for Vaccines and Immunotherapeutics against Diverse Emerging Infectious Threats
The overarching goal of PROVIDENT (Prepositioning Optimized Strategies for Vaccines and Immunotherapeu- tics against Diverse Emerging Infectious Threats) is to deliver “plug-and-pl...
CORE A: Administrative Core
The overarching goal of the PROVIDENT consortium is to develop "plug-and-play" vaccine and therapeutic antibody blueprints for three major groups of emerging enveloped RN...
Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients
PROJECT SUMMARY Over 2.2 million US patients are estimated to have limb loss, with the number projected to rise to 3.6 million by 2050. The current standard for rehabilitation and...
A Plug-and-Play Platform for Continuous Directed Evolution of Nonribosomal Peptide Synthetases
Project Summary Nonribosomal peptides (NRPs) are an abundant class of microbial natural products: small molecules with evolved chemical structures and biological activities that ma...
High Q Technologies FATHOM Pulse EPR Spectrometer
Project Summary/Abstract We request funds to purchase a Bruker Biospin Corp. Q-Band Elexsys E580 Pulse EPR Spectrometer (Pulse EPR) to enable structural dynamics studies of protein...
120 kV Transmission Electron Microscope for CU Anschutz Electron Microscopy Core Facility
Project Summary/Abstract: We are requesting funds to purchase a Hitachi 7800 transmission electron microscope (TEM) for the Electron Microscopy Core Facility (EMCF) at CU Anschutz...
Refining iPSC-Based Spinal Cord Model Systems by Fabricating Developmentally Programmed Extracellular Matrix Cues
ABSTRACT Cellular reprogramming and induced pluripotent stem cell (iPSC) technologies have provided unprecedented access to the human central nervous system (CNS). They have enable...
STED Super-resolution Imaging System
Project Summary We are requesting funds to purchase an Abberior Facility-line STED microscope for the Advance Cell Imaging Core (ACIC) at the Medical College of Wisconsin (MCW). Th...
7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimer’s Disease
ABSTRACT Mixed pathologies of cerebral small vessel disease (SVD) and Alzheimer’s disease (AD) represent the most common cause of dementia in the elderly population. The presence o...
Caregiver–Child Proximity and Attachment Security
PROJECT SUMMARY/ABSTRACT Research has shown that the security of a child's attachment to their primary caregiver is crucial to their social relationships and overall well-bein...
Defining the Role of IL-1? in Tungsten-Mediated Cardiovascular Disease
Project Summary/Abstract Inhalation of particulate matter is a known risk factor for the development of cardiovascular disease. Tungsten is an emerging environmental contaminant, p...
Plasma-Based Neuronal Insulin Signaling Exosomes as a Biomarker for Cognitive Impairment in Diabetes
Project Summary Approximately 30% of older adults in the United States have diabetes mellitus (DM). Alzheimer’s disease and Alzheimer's disease-related dementias (AD/ADRD) are...
TFS Talos-L120C, a 120kV transmission electron microscope for structural studies
Structural investigation of biological complexes at near atomic resolution is essential to illuminating the molecular mechanism of biological systems under physiological and pathol...
Acquisition of a Supercritical Fluid Chromatography Mass Spectrometer System
Project Summary This proposal requests funding to purchase a Waters Acquity UltraPerformance Convergence Chromatography (UPC2) system equipped with photodiode array and single-quad...
The Super Argus PET/CT 6R for Pre-clinical Oncology Research
7. Project Summary/Abstract Funds are being requested to purchase a Super Argus PET/CT 6R small-animal PET (positron emission tomography) and CT (transmission computed tomography)...
A multiplex automatic autostainer at Jefferson
Project Summary and Abstract The Translational Pathology Shared Resource (TPSR) laboratory at the Sidney Kimmel Cancer Center (SKCC) is dedicated to providing exceptional pathology...
Zeiss LSM 980 confocal with Airyscan 2
Project Summary This instrumentation request is for funds to purchase a Zeiss LSM 980 confocal with Airyscan2 microscope to upgrade obsolete confocal microscopes that are approachi...
Evaluation of combination CLK/DYRK (Cirtuvivint) inhibition with PARP inhibition (Olaparib) in BRCA/HRD platinum resistant ovarian cancer
PROJECT SUMMARY/ABSTRACT Approximately 50% of patients with ovarian cancer harbor deficiencies in DNA damage repair with either a germline/somatic mutation in BRCA1/2 or homologous...