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606,025 grants found
Showing 27,801 – 27,820 of 606,025 grants
Non-Apoptotic Functions of Caspase-3 in Brainstem Development
ABSTRACT Auditory function relies on highly specialized and precise neuronal connectivity. A significant challenge for the field of auditory neuroscience is to understand how these...
CCL-IGNITE (IncreasinG RepresentatioN In RehabilItation and CreaTivE Health Professions Research)
Project Summary / Abstract In this R25 application, NYU Steinhardt faculty in rehabilitation health professions research (RHP, including physical therapy, occupational therapy, com...
INCLUSIVE PREK STEM PLAYGROUPS: EMPOWERING OUR YOUNGEST LEARNERS AND THEIR CAREGIVERS FOR CONFIDENCE AND COMPETENCE IN STEM LEARNING
Inclusive PreK STEM Playgroups: Empowering our Youngest Learners and their Caregivers for Confidence and Competence in STEM Learning Project Summary/Abstract There are STEM opportu...
Elevating Mentoring Possibilities for Overcoming Withstanding Educational Roadblocks in Sickle Cell Disease (EMPOWER SCD): STEMM mentoring for youth with sickle cell disease
Project Summary/Abstract One fifth of the school-age population in the US have a chronic medical illness or disabling condition that puts them as an educational disadvantage.1 This...
Optimizing FACED for robust large-scale activity recording
SUMMARY/ABSTRACTA longstanding challenge in neuroscience is how to monitor neuronal signaling and activity at cellular resolution over a large area/volume with millisecond time res...
AI4Health: Engaging Adolescents in Artificial Intelligence to Promote Pathways to Biomedical Careers
Project Summary/Abstract Developing a diverse biomedical workforce is a critical national need. The next generation of biomedical researchers and health science professionals will...
Glia in Aging
ABSTRACT Because of the increase in life expectancy, a larger fraction of the population is now elderly and afflicted by age- related diseases with a huge cost for the health care...
A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance
Summary Antimicrobial resistance (AMR) is a prominent healthcare threat with an estimated 4.95 million cases associated with bacterial AMR in 2019, and poses a particularly difficu...
Tracking brain dynamics of the acute stress response and neurocognitive mechanisms of chronic alcohol consumption
ABSTRACT Excessive alcohol use is a significant and serious public health problem, with 28.6 million US adults meeting diagnostic criteria for current alcohol use disorder (AUD). T...
Omic Approaches to Factor VIII Inhibitor Development in Hemophilia Patients of Mexican Descent
PROJECT SUMMARY/ABSTRACT Bleeding in Hemophilia A (HA) is currently prevented by regular infusions of therapeutic factor VIII (FVIII) proteins (tFVIIIs). Unfortunately, ~30% of all...
Characterize longitudinal events of oral high-risk human papillomavirus among an at-risk population (CLEAR)
Project Summary/Abstract Males living with HIV are estimated to be at a 2- to 5-fold higher risk of developing human papillomavirus- related oropharyngeal cancer (HPV-OPC) compared...
The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease
Key prodromal events in Alzheimer’s disease (AD) revolve on altered electrical signals and buildup of garbage proteins in vulnerable areas before signs of AD (locus coeruleus, LC))...
The Role of Myeloid Cell Transendothelial Migration in Non-Proliferative Diabetic Retinopathy
PROJECT SUMMARY Diabetic Retinopathy (DR) is the most common complication of diabetes and is the leading cause of vision loss in working-aged adults. DR is classified into non-prol...
A Sleep Hygiene Intervention to Improve Sleep Health in Urban, Latino Middle School Children
Project Summary/Abstract: Sleep is essential for optimal health and development. Poor sleep is associated with impaired functioning and academic performance, and worse health outco...
Elucidating the roles of protein disaggregases and developing enhanced diaggregases to counter diverse protein-misfolding disorders
PROJECT SUMMARY The proper folding of proteins is essential for all life, making aberrant protein folding severely problematic. The protein homeostasis (proteostasis) network is a...
A Functional Analysis of Arginine Methylation
PROJECT SUMMARY/ABSTRACT Our goal is to broadly understand the biological roles of arginine methylation, a very common post-translational modification (PTM). This PTM is deposited...
Developing Trauma Networks of Children, Adolescents, and Young Adults to Examine the "Ripple Effect" of Firearm Injuries
PROJECT SUMMARY/ABSTRACT Firearm injury and death is a public health epidemic that spreads through communities and social networks in the United States much like an infectious dise...
FGF21 protects from progressive metabolic syndrome after undernutrition refeeding
Project Summary This application will study the effects of undernutrition on the development of the metabolic syndrome (MetS) after refeeding. Studies showed that undernutrition in...
Jawbone is unique: differential responses to growth factor signaling and mechanical loading
ABSTRACT Craniofacial bone health is important to support eating, speaking, breathing, and expressing emotions, and is critical to overall health and quality of life. It is known t...
The Effect of Hospital-Physician Vertical Integration on Costs, Quality, and Utilization for Insured Patients with Multiple Chronic Conditions
Project Summary Improving the quality of care for patients with multiple chronic conditions (MCCs) continues to be a national priority. Concurrently, hospital-physician vertical in...