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606,025 grants found
Showing 27,781 – 27,800 of 606,025 grants
Caring Contacts via text message for suicidal adolescents after emergency department discharge
Project Summary (Abstract) The purpose of this Mentored Patient-Oriented Research Career Development Award is to prepare Jennifer Hoffmann, MD, MS, a pediatric emergency medicine p...
Rho dependent regulation of Clostridioides difficile virulence
Project Summary Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobic bacterium and opportunistic pathogen. C. difficile infection (CDI) is associated with...
Probing the ribosome-dependent mechanisms of human alphacoronavirus Nsp1
Project Summary The development of specific therapeutics infectious coronaviruses remains a significant challenge and requires a detailed mechanistic understanding of virus–host ce...
Novel phospholipase involved in outer membrane homeostasis in Pseudomonas aeruginosa
Project Summary The Gram-negative outer membrane (OM) is an effective permeability barrier against numerous chemical assaults, including antibiotics. The intrinsic barrier capacity...
Understanding Kras Mutation Heterogeneity in PDAC
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent neoplastic disease of the pancreas, and it is expected to become the second leading cause of cancer re...
Therapeutic potential of CC-90009 for cystic fibrosis
PROJECT SUMMARY/ABSTRACT Cystic fibrosis (CF) is an inherited, multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that e...
Mechanistic insights into lipid A modification by the phosphoethanolamine transferase MCR-1
Project Summary Phosphoethanolamine (PEA) transferases are bacterial inner membrane proteins that catalyze the addition of PEA from phosphatidylethanolamine (PE) donor substrate to...
Neural mechanisms of psilocybin-assisted treatment for alcohol use disorder.
Preclinical and clinical research provides strong evidence that psilocybin and other 5-HT2A agonist/partial agonist psychedelics have antiaddictive effects. In a double-blind rando...
Engineering the Premetastatic Niche
Project Summary The majority of breast cancer related deaths occur as a result of metastasis. Once the cancer cells metastasize, the 5-year relative survival rate for breast cancer...
Ionic liquid-based nanoemulsion containing combination antiretroviral drugs for the oral and transdermal treatment of HIV infection
PROJECT SUMMARY Two-drug regimen (2-DR) containing potent second-generation integrase inhibitor (INI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) are currently avail...
Mass Spectrometry-Based Biochemical Analysis of Single Cells Beyond the Global Proteome
PROJECT SUMMARY/ABSTRACT Biological tissues exhibit a high degree of phenotypic heterogeneity and plasticity, comprising many different subpopulations of cells in various states. Q...
Development of antifungal drug resistance in the oral environment over the course of HIV infection
Fungal infections are an increasing human health risk, and the development of fungal resistance to the limited repertoire of available drugs is exacerbating this threat. Five speci...
Organ system cross talk in ischemic heart disease
PROJECT SUMMARY/ABSTRACT This proposal’s objective is to determine whether changing the signaling patterns between the skeletal stem cells (SSCs) and hematopoietic stem cells (HSCs...
Characterization of full-lengh CPSF6 and its interaction with HIV capsid
PROPOSAL SUMMARY / ABSTRACT: HIV is a retrovirus that achieves infection through integration of its viral DNA into the host genome of non- dividing cells. To execute this function,...
Identifying Unique Neural and Inflammatory Mechanisms of Depression in People Living with HIV
ABSTRACT People living with HIV (PLWH) are particularly vulnerable to depression, which negatively affects their quality of life, medication adherence, and even mortality. Nearly 6...
Post-transcription Initiation Control of Gene Expression
Project Summary/Abstract A unifying theme of my research program is to determine how RNA structure regulates gene expression co-transcriptionally by affecting the activity of RNA p...
Chemical Biology Approaches for Investigating RNA-Protein Interactions
Recent studies have shown that RNAs are invariably bound to and often modified by RNA-binding proteins (RBPs). Thus, it is no surprise that RBPs have been found to play key roles i...
Cucurbit[n]uril-Type Molecular Containers
Project Summary / Abstract. The PI is Professor at the University of Maryland College Park since 1998 where he runs a lab focusing on the design and synthesis of new cucurbit[n]uri...
CTSA K12 Program at Stanford
PROJECT SUMMARY/ABSTRACT Training the next generation of translational scholars who can innovate, think creatively, and apply rigorous and responsible research principles to major...
Ion Channels in Synaptic and Neural Circuit Physiology Course (2024-2028)
ABSTRACT Ion channels are the fundamental building blocks determining cellular activity and in particular neuronal excitability. The most elementary processes in the nervous system...