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606,025 grants found
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Novel enhancement of antibody therapy through NOD2 activation
PROJECT SUMMARY Our long-term objective is to understand the expression and function of monocyte/macrophage Fcγ receptors with a goal of improving antibody-based therapies for dise...
The role of H3K4 demethylases in alcohol-associated liver disease development and resolution
PROJECT SUMMARY Alcohol-associated liver disease (ALD) is a major cause of alcohol related mortality. The specific mechanisms responsible for ALD development and progression are no...
Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies
SUMMARY Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies There is an unmet need to identify predi...
Improving the Processes around Approval, Accrual and Translational Research in Cancer Prevention Trials
ABSTRACT The central goal of this R50 Clinician Scientist Award application is to establish and refine processes that facilitate clinical trials in cancer interception at The Unive...
Assessing human papillomavirus type 16 transforming vs productive infections in oral epithelia
Project Summary/Abstract The goal of this K99/R00 application is to support and facilitate the transition of Dr. Robert Jackson’s mentored postdoctoral research project to an indep...
Epigenetics, DNA repair and Genomics (EDGe) Training Program in Cancer
Here we propose a new Epigenetics, DNA repair and Genomics (EDGe) Training Program in Cancer to support 4 pre-doctoral students per year. EDGe will take advantage of a thematic int...
Promoting Adherence to Chemotherapy Handling Guidelines Among Oncology Nurses
PROJECT SUMMARY/ABSTRACT Chemotherapy exposure is a serious occupational hazard affecting oncology nurses. It could lead to infertility, fetal anomalies, and cancer. Chemotherapy e...
Regulation of blood flow in the brain by capillary KATP channels
PROJECT SUMMARY: Approximately 90% of the blood vessels in the brain are capillaries, which have been traditionally viewed solely as a dense and passive network of tiny vessels whi...
Characterization of the Staphylococcus aureus fatty acid degradation pathway
PROJECT SUMMARY/ABSTRACT Bacteria require fatty acids for a variety of biological functions, including the construction of phospholipids. Staphylococcus aureus, like other bacteria...
Conditional Animal Models of mtDNA Disease
Conditional Animal Models of mtDNA Disease: Abstract Mitochondria are critical for metabolism, organ homeostasis, apoptosis, and aging. This wide range of impact is manifested by t...
Long-acting PTH for hypoparathyroidism
Project Summary Hypoparathyroidism is a rare disease that results from a deficiency or inability to make sufficient amounts of parathyroid hormone (PTH). Untreated or inadequately...
Hybridization Chain Reaction: Automated Ultrasensitive Multiplex RNA and Protein Imaging
Project Summary Hybridization Chain Reaction: Automated Ultrasensitive Multiplex RNA and Protein Imaging Encoded in the genome of each organism, biological circuits direct developm...
Multi-Modality Optical Molecular Imaging System for Preclinical Cancer Models
Project Abstract With the advent of fluorescence probes targeting specific cellular and subcellular events, the role of fluorescent imaging in preclinical arena is getting rapidly...
Redox Regulation of Host Ribosomal Proteins during Helicobacter pylori infection
PROJECT SUMMARY Helicobacter pylori infection is commonly associated with several gastric diseases including gastritis, peptic ulcer disease, lymphoma of the mucosa-associated lymp...
Molecular mechanism of INAFM2 in metastasis
PROJECT ABSTRACT Metastasis is the major cause of mortality in cancer patients and accounts for about 90% of cancer deaths, which has not changed in the past 50-years. This indicat...
Characterization of PHF7 function in mediating cardiac reprogramming
Project Summary The goal of this K08 application is to provide a rigorous 5-year scientific and career development training planthat will facilitate the transition of Dr. Glynnis G...
The fertility, maternal health, and infant health consequences of reproductive policy change
PROJECT SUMMARY The Dobbs v. Jackson Women’s Health Organization Supreme Court decision, which eliminated federal protections for abortion rights, is an unprecedented policy change...
Hypothalamic circuitry underlying the circadian control of sexual drive and reproduction
Physiological and biochemical processes in nearly every species (including humans) are regulated by the circadian clock. For example, the reproductive system (of females) requires...
Defining Novel Redox Stress Mechanisms to Inhibit KRAS-driven Pancreatic Ductal Adenocarcinoma
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths with a 5-year survival rate of 12%. Over 90% of PDAC is driven by oncogenic KRAS, howeve...
THE ROLE OF CORTICOTROPHIN RELEASING FACTOR RECEPTOR 1 NEURONS IN THE BED NUCLEUS OF THE STRIA TERMINALIS IN MODULATING WEIGHT HOMEOSTASIS
Project Summary and Abstract: The United States currently faces an epidemic of diseases related to an inability to maintain a healthy body weight (weight homeostasis, WH). The infl...