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606,025 grants found
Showing 27,741 – 27,760 of 606,025 grants
Project 1: Combined Suppression of MYC as therapy for CRPC: the COSMYC trial
PROJECT 1 – PROJECT SUMMARY Prostate cancer cells (PCa) are highly adaptable in response to the tumor microenvironment. In response to chronic exposure to a low testosterone enviro...
Project 2: Dual Targeting of B7-H3 in mCRPC
PROJECT 2 – PROJECT SUMMARY Immune-checkpoint blockade has resulted in unprecedented treatment advances in multiple tumor types, despite yielding modest results in prostate cancer...
Project 3: Induction of synthetic lethality with combined DNMT and PARP inhibition
PROJECT SUMMARY Recent data have shown that PARP inhibitors are an effective therapeutic strategy for DNA repair-deficient metastatic castration-resistant prostate cancer (mCRPC)....
Biospecimen Core
Project Summary/Abstract: The primary goal of the Biospecimen/Pathology Core B is to facilitate translational research related to prostate tissue-based studies. The major functions...
Biostatistics Core
CORE C: Biostatistics/Bioinformatics Core PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (Core C) provides support to the 3 primary projects, and Career Enhance...
Developmental Research Program
Project Summary/Abstract The Developmental Research Program (DRP) is a special feature of the SPORE grant that allows sponsored institutions to fund important new pilot projects wi...
Career Enhancement Program
Project Summary/Abstract: The Career Enhancement Program (CEP) is a special feature of the SPORE grant which allows sponsored institutions to support junior faculty or established...
Impact of nigral and extranigral neurodegeneration on aerodigestive discoordination in a pesticide model of Parkinson's disease
Project summary Swallowing problems in Parkinson’s disease (PD) affect 90% of patients, with significant consequences for quality of life and morbidity, and are resistant to curren...
Cocoa Flavanols for Migraine: A Pilot Study
Project SummaryMigraine, a chronic intermittent headache disorder, ranks in the top five causes for years lived with disability. Approximately 15% of the US population experiences...
Clinical Methods for Nutrition and Obesity Research Course
PROJECT SUMMARY Obesity is a chronic disease that affects more than 650 million adults worldwide and has been acknowledged as a leading cause of death in the U.S. Obesity also pred...
Regulation of coagulation and thrombosis by C1 inhibitor
PROJECT SUMMARY Venous thromboembolism is a leading cause of morbidity and mortality in the United States. The contact pathway of coagulation plays an important role in the pathoge...
Efficacy and Safety of Proteolytic Activity-Guided fecal Microbiota Transplantation for Irritable Bowel Syndrome (PRAGMAT trial)
ABSTRACT Irritable bowel syndrome (IBS) is estimated to affect 1 in 6 U.S. adults and results in significant morbidity and health care utilization. Studies over the last decade hav...
Construction of A Lung Cancer Preclinical Model Cross-comparison Platform
Project Summary Preclinical models of lung cancer are essential tools for researchers to understand cancer biology and develop therapeutic strategies. Choosing the most cost-effect...
Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias
ABSTRACT The effective causative therapies for Alzheimer’s Disease (AD) and related dementias (ADRDs) remain elusive because the patients are often diagnosed at an advanced state o...
Mental health and work-related wellbeing of U.S. obstetrician-gynecologists in a shifting policy climate
PROJECT ABSTRACT U.S. physicians are at risk for poor mental health and work-related wellbeing. Obstetrician- gynecologists (OB-GYNs) are at particularly high risk due to recent ch...
Enhancing accrual and diversity across gynecologic and solid tumor trials
PROJECT SUMMARY/ABSTRACT My clinical research program focuses on improving the lives of all women with gynecologic malignancies. I serve as the lead for the clinical trials program...
Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics Experiments
Abstract Recently, high-throughput spatial omics technologies have made it possible to simultaneously measure close- to-cell-level gene or protein expressions and spatial locations...
IL-27 is a protective cytokine during congenital infection
Cytokines govern key cellular processes of pregnancy with both pro- and anti-inflammatory activities. To prevent immune dysregulation at the maternal-fetal interface, cytokines are...
Targeted nutritional approach to restore muscle health and physical activity after sepsis
ABSTRACTSepsis is a potentially life-threatening complication of an infection in critically ill patients and is characterized by severe tissue breakdown, leading to long-term muscl...
N-glycosylation as a regulator of Grp94 Function and Activity
PROJECT SUMMARY Most newly synthesized proteins destined for the cell surface or secretion must transit through the endoplasmic reticulum (ER) for folding and post-translational pr...