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606,025 grants found
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Turn-PD: A Co-designed Rehabilitation Programme To Improve Turning And Reduce Falls In Parkinson’s Disease
Background Falls are common in people with Parkinson's disease (PwP), resulting in reduced quality of life, increased hospital admission, and reduced life expectancy.Falls com...
Improving the care of patients with acute respiratory failure on the standard hospital ward
Background Each year, more than 600,000 patients are admitted to NHS hospitals and treated for acute respiratory failure. This serious condition has a high mortality rate (30-50%)...
A co-design project to develop, and assess the acceptability and feasibility of, an intervention to support prevention of weight gain and/or encourage weight reduction in people with Spinal Cord Injury within Specialist Spinal Injury Centres
Background There are over 50,000 people in the UK living with a Spinal Cord Injury (SCI), and 2,500 people acquiring a SCI annually. SCI is life changing, resulting in paralysis.Ch...
Understanding and Preventing Cardiovascular diseases in people taking AntiPsychotic medications: a data-driven mixed methods study (PreCAP)
Background People taking antipsychotics face a 2-4-fold higher risk of cardiac mortality and sudden cardiac death respectively compared to those without antipsychotic exposure.Pres...
Improving mental health peer support for children and young people: A mixed methods realist modelling study
Background Mental health problems are a leading cause of health-related burden across the world. Since 2017 in England, rates of mental health problems in children have increased b...
PROACTIVE: HePatitis C Reinfection: Optimising surveillAnCe for deTectIon and preVEntion
Background Optimising annual follow-up testing for Hepatitis C Virus (HCV) following treatment for people who inject drugs (PWID) is key to achieving, and measuring progress toward...
SUSTENANCE: Development of a toolkit to improve poSt-operative feeding practices and nUritional intake in patientS wiTh hEad and Neck cANCer undergoing surgEry with flap tissue reconstruction.
Background Surgery is a widely accepted treatment for head and neck cancer (HNC).After surgery, patients are made 'nil-by-mouth' for approximately 6-12 days to enable wou...
Co-design and feasibility testing of a tailored self-management intervention for adults living with sickle cell disease
Background Sickle Cell Disease (SCD) is an inherited blood disorder associated with multisystem complications, acute and persistent pain and fatigue.SCD-related pain results in bio...
Optimising analgosedation in extracorporeal membrane oxygenation using a co-designed protocol: Feasibility and acceptability of a cluster randomised controlled trial
Background Analgosedation is commonly administered to intensive care unit (ICU) patients receiving extracorporeal membrane oxygenation (ECMO) to control pain, minimise distress and...
How can anticoagulant thromboprophylaxis be personalised to reduce the risk of venous thromboembolism in acutely ill adult medical patients?
Background Venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis, is a leading cause of morbidity and mortality in hospitalised patients. Over half of...
Understanding how unregistered practice in social work can be developed and guidance, training and support targeted to improve outcomes and provision for people accessing adult social care services.
In local authorities (LAs) in England, unregulated staff, referred to here as 'other trained staff' (OTS) are independently managing caseloads and undertaking increasingl...
How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changes
Summary RNA Binding Proteins (RBPs) are key regulators of gene expression. The mammalian genome encodes well over 2,000 RBPs, exceeding the number of transcriptional regulators, an...
Analytical approaches to fatty acid oxygenases and their lipid mediator products
Analytical approaches to fatty acid oxygenases and their lipid mediator products Project Summary/Abstract This program focuses on technically challenging questions related to lipox...
Regulation of Germ cell to maternal transition
Abstract The gametes arise either from germ cells or germline stem cells (GSCs), by undergoing differentiation and meiosis. The gametes help launch the next generation by sustainin...
From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural Products
ABSTRACT My research has aimed at accessing a previously hidden source of natural products that are encoded in bacterial genomes, and at investigating their structures, functions,...
Resolving the interaction network of cell surface receptors
PROJECT SUMMARY/ABSTRACT Cell signaling is initiated at the plasma membrane (PM), but our understanding of the chemical interactions that regulate membrane protein function is stil...
Genomic Medicine Master of Science (M.S.) Degree Program
As DNA sequencing becomes faster and cheaper, utilization of whole exome sequencing (ES) and whole genome sequencing (GS) as a diagnostic tool has become widespread. It is essentia...
Multidisciplinary Training in Gastrointestinal Cancers
PROJECT SUMMARY Gastrointestinal (GI) cancers, which include malignancies of the esophagus, stomach, pancreas, colorectum, small intestine, and liver, constitute the plurality of c...
SPORE in Prostate Cancer
Overall Project Summary/Abstract Prostate cancer has become the most frequently diagnosed cancer in men in the United States (US) and a major cause of cancer morbidity and mortalit...
Administrative Core
Project Summary/Abstract: The Administrative Core is responsible for the managerial oversight of all Johns Hopkins Prostate SPORE Program activities. In addition, the Core continue...