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606,025 grants found
Showing 27,081 – 27,100 of 606,025 grants
Epidemiology of Post-Treatment Lyme Disease Syndrome
ABSTRACT: Project 1, The Epidemiology of Post-Treatment Lyme Disease Syndrome A proportion of early Lyme disease patients who have been treated with standard antibiotic regimens ex...
Enhancing efficacy of virus-specific T cell therapy following hematopoietic stem cell transplantation by CD52 knockout
Viral infections are common and can be severe in immunocompromised patients, including those undergoing hematopoietic stem cell transplantation (HSCT) or solid organ transplantatio...
Facilitating the Implementation of Population-wide Genomic Screening across Diverse Populations and Settings (FOCUS)
PROJECT SUMMARY Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers great promise in...
Dopaminergic Control of Glial Cells in Prefrontal Cortex Functions
Project Summary Recent research in the study of brain functions is highlighting the important role of glial cells in several human neurological and psychiatric disorders. The dopam...
Monocyte and Macrophage Functional Evolution in Kidney Transplantation
Access to kidney transplantation as a cure for end-stage kidney disease is severely limited by donor organ shortage. Exacerbating this shortage is the need for re-transplantation r...
Neural circuit mechanisms in observational spatial working memory
PROJECT SUMMARY Observational learning is a type of social learning and a fundamental cognitive behavior in humans and social animals. How neural circuits in the brain enable this...
Unite 2 Fight Paralysis Annual Science and Advocacy Symposium
Project Summary/Abstract The goal of this application is to support additional efforts to enhance the diversity, equity, and inclusion of participants for the Unite 2 Fight Paralys...
Scalable discovery of saccharide natural products using high-throughput multi-omics
Project Summary. Antibiotic resistance is becoming a major public health problem worldwide, with antibiotic resistant pathogens infecting hundreds of millions and killing over a mi...
TT-036 for the treatment of scleroderma-associated pulmonary fibrosis
ABSTRACT Fibroproliferative illnesses leading to organ fibrosis and failure are responsible for approximately 45% of deaths in developed countries. Whether idiopathic, triggered by...
Development of a Novel Aqueous Humor-Based Multiplex Assay for Uveal Melanoma Metastatic Risk Prediction
Project Summary Uveal melanoma (UM) is a prevalent intraocular cancer, with approximately 3,000 new cases annually and an estimated total of 60,000-70,000 affected individuals in t...
Advancing Diabetic Foot Ulcer Treatment with Provasliex, a Controlled PDGF Release Hydrogel for Promoting Vascularization and Managing Overactive Inflammation
Summary GelSana is developing the Provasliex GelTM, a zwitterionic hydrogel that delivers controlled release of platelet derived growth factor (PDGF) to address the need for better...
Flexible, scalable, and generalizable photogrammetric head modeling for high-density diffuse optical tomography
Project Summary: EsperImage, a startup company out of Washington University (WUSTL), will develop efficient and flexible data registration and modeling procedures to complement the...
Field-deployable analyzer for aqueous uranyl concentration
This NIH SBIR Phase I project addresses the critical need for rapid, in-field, and accurate monitoring of uranium in drinking water sources. Uranium contamination poses severe envi...
A First-in-Class Therapeutic Antibody for Treatment of Acromegaly
Project Summary: Acromegaly is a chronic, rare endocrine disorder that affects approximately 21,000 adults in the US that is most often caused by a non-cancerous pituitary tumor th...
Localizing Health Disparities and Predicting Morbidity and Mortality for HIV-Related Opportunistic Infections
PROJECT SUMMARY People who present with Acquire Immunodeficiency Syndrome (AIDS) are at high risk of developing an opportunistic infection and death. Opportunistic infections (OIs)...
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
PROJECT SUMMARY Among the ~2.5 million persons who develop incident tuberculosis (TB) in sub-Saharan Africa annually, about one in five does not complete treatment, even though hig...
Ethical Considerations in The Design and Testing of Back-Support Exoskeletons
Project Summary Low-back pain is the primary cause of disability across the world, and over 80% of workplace injuries also occur to the lower back. Wearable robotic technologies, s...
Resting and Dynamic Brain Glutamate by MRS In Vivo: Relation to Suicidal Behavior
Project Summary Suicide is a leading cause of premature death in the United States (US). Convergent evidence across genetic, postmortem, and immunohistochemical studies suggest a r...
Defining pediatric intestinal failure natural history
Pediatric intestinal failure (IF) is a rare condition that affects under 25,000 individuals in the United States. Children with IF require parenteral nutrition to provide enough ca...
Progressing toward clinical trial readiness in CCHS: Natural history study to incorporate patient voice, harmonize clinical and registry data, and standardize assessments
Abstract Congenital central hypoventilation syndrome (CCHS) is a rare and severe neurocristopathy caused by PHOX2B gene mutations. CCHS is characterized by profound hypoventilation...