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606,025 grants found
Showing 27,041 – 27,060 of 606,025 grants
Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research Fellowship
SUMMARY Increased attention must be given to the health of women living with HIV (WLHIV) across all stages of their lives, especially in sub-Saharan Africa and countries like Kenya...
Acceptability, barriers and facilitators to integrating menopausal syndrome screening at Kenyatta National Hospital
Kenya has a high burden of generalized HIV with women disproportionately affected. The use of highly active antiretroviral therapy (HAART) has improved survival of people living wi...
Tanzania AIDS Malignancies Training and Research Program (TAMTRP)
Despite the progress in the fight against HIV/AIDS, women around the world remain disproportionately affected by HIV. More than half of the HIV cases globally are women, and young...
HIV Basic Science and Cure Research Training for Scientists at the University of Ghana (H-Cure-RT)
PROJECT SUMMARY This program is an extension of our successful HIV basic science training program with the HIV Cure Research Infrastructure Studies (H-CRIS) based at the University...
Hormonal contraception choice and safety among people with sickle cell disease
Project Summary Estrogen-containing hormonal contraception and injectable progestin-only contraception have been associated with venous thromboembolism (VTE) and stroke in the gene...
Bioengineered 3D tooth germs for tooth regeneration in vitro and in vivo
Project Summary Dental decay and tooth loss are common problems. Bridges and implants are the primary treatment options but cannot completely restore the tooth biology and function...
Center for Biomedical OCT Research and Translation
Project Summary Polarization-sensitive optical coherence tomography (PS-OCT) was introduced more than 20-years ago but has only recently reached the level of technological maturity...
Optimizing singlet oxygen dosimetry for photodynamic therapy (PDT)
Optimizing Singlet Oxygen Dosimetry for Photodynamic Therapy (PDT) Abstract The overall objective of this project is to optimize clinical singlet oxygen (1O2) dosimetry (SOD) via t...
Administrative Supplement: Adverse childhood experiences and alcohol misuse in Latino adolescents
Project Summary The purpose of this K supplement is to request support following the impending critical life event of childbirth. I was awarded an NIAAA K08 in February 2022, had m...
Modeling a national Graduated-BAC per se policy for 21-24 y/o drivers to reduce alcohol impaired driving injury and fatal crashes
PROJECT SUMMARY The national comprehensive societal cost from alcohol-impaired crashes is estimated at over $348 billion, with $296 billion attributable to ≥ .08 BAC cashes. In the...
Development of tools to identify and characterize UDP-Sugar metabolite RNA caps
Recent advances in both mass spectroscopy and next generation sequencing methodology have revealed a new class of 5’ end RNA modification, which resembles the canonical eukaryotic...
Mechanisms of intracellular iron dysregulation in kidney fibrosis and reno-protective strategies
Chronic kidney disease (CKD) affects 10-15% of the population worldwide.More than 37 million people are estimated to have CKD in the US, and 2 in every 1000 Americans need dialysis...
The Functional Role and Neural Basis of Rapid Turns in Olfactory Search Behavior
Summary When searching their environment for food, animals often switch from making random changes in direction to reflexively orient upstream when they smell an attractive odor, f...
Disparities in Immuno-oncology Outcomes in Detroit (DIODE)
Project Summary This application will address cancer health disparities in Black residents of metropolitan Detroit, specifically evaluating racial differences in genetic regulation...
Administrative Core
Project Summary The overall goals of this P20 application are (1) to identify ancestry-specific genetic regulators of macrophage function and response to anti-HER2 antibody therapy...
Examining maternal lifetime exposure to structural racism and metabolomics in neonatal dried blood
Structural racism (SR) denotes the multidimensional and systemic oppression of Black individuals in the US. Residential segregation is a central component of SR. According to exper...
Targeting P21 positive senescent cells for alleviating TMJ degeneration
Abstract Temporomandibular Joint (TMJ) degeneration is a painful and debilitating disease of the synovial joint, affecting over 20 million people in the United States. Obesity, adv...
Mechanism of Myocardial Fibrosis Induced by Mitral Valve Prolapse
Mitral valve prolapse (MVP) affects 1 in 40 individuals and is complicated in 30-35% by ventricular arrhythmias that increase risk for sudden cardiac death (SCD). Such arrhythmias...
Osteocytic mechanisms required for spatiotemporal control of bone quality
SUMMARY Bone fragility cannot be explained by bone mineral density (BMD) alone and also results from defects in the material properties of the bone matrix, termed bone quality (BQ)...
P7C3 based small molecule for Heart failure treatment
Summary NAD+ is biosynthesized mainly through the salvage pathway and is central for cellular homeostasis and energy production. Deficiency of NAD+ results in disruption of cellula...