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Showing 27,12127,140 of 606,025 grants

Active NON-SBIR/STTR RPGS
5/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
NATIONAL INSTITUTE OF MENTAL HEALTH University of Chicago United States 2024 – 2029

PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...

$2.87M
USD
Active NON-SBIR/STTR RPGS
Skeletal Myosin-Binding Protein C: Defining Function Across Scales Using a Zebrafish Model System.
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... University of Vermont & St Agric College United States 2024 – 2026

Myosin-binding protein C (MyBP-C), a thick filament associated protein of vertebrate striated muscle, is a key modulator of muscle contractility. Multiple distinct skeletal muscle...

$2.02M
USD
Active OTHER RESEARCH-RELATED
Rensselaer Alzheimer’s Fellows to Accelerate Entrepreneurship in Life Sciences (RAFAELs)
NATIONAL INSTITUTE ON AGING Rensselaer Polytechnic Institute United States 2024 – 2029

Project Summary The proposed Rensselaer Alzheimer’s Fellows to Accelerate Entrepreneurship in Life Sciences (RAFAELs) program will augment existing research and entrepreneurial act...

$2.63M
USD
Active NON-SBIR/STTR RPGS
Methods to build and annotate tissue atlases using spatial genomic data
NATIONAL HUMAN GENOME RESEARCH INSTITUTE J. David Gladstone Institutes United States 2024 – 2028

Project Summary/Abstract Single-cell spatial technologies hold the promise of understanding spatially-resolved cell state and discovering how cells interact locally to create compl...

$8.3M
USD
Active NON-SBIR/STTR RPGS
Impact of dietary lipids on pancreas cancer initiation and progression
NATIONAL CANCER INSTITUTE University of California Los Angeles United States 2024 – 2026

PROJECT SUMMARY Despite advances in cancer treatment, the five-year survival rate for pancreatic ductal adenocarcinoma (PDA) is 12%. Obesity has been linked to PDA risk epidemiolog...

$2.58M
USD
Active NON-SBIR/STTR RPGS
Fimepinostat, Combination HDAC and Pi3-kinase Inhibitor Tumor-Directed Therapy for Cushing Disease (IND 168501 - 07/31/2023)
FOOD AND DRUG ADMINISTRATION University of California Los Angeles United States 2024 – 2028

Abstract Cushing Disease (CD) a life-threatening “orphan disease” with an annual US incidence of ~8 cases per million. It is caused by an adrenocorticotropic hormone (ACTH)-secreti...

$4.25M
USD
Completed SBIR-STTR RPGS
Novel treatment for urinary incontinence and overactive bladder symptoms in the elderly
NATIONAL INSTITUTE ON AGING Dignify Therapeutics, Llc United States 2024 – 2026

Abstract Urinary incontinence (UI) and symptoms of overactive bladder (OAB) become more prevalent with age. The impact on elderly and their caregivers makes it difficult to continu...

$3.9M
USD
Active NON-SBIR/STTR RPGS
Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Arizona State University-Tempe Campus United States 2024 – 2027

Abstract Type 1 diabetes (T1D) is a multifactorial disease caused by a complex interplay of genetic and environmental factors. The genes that mediate disease susceptibility have la...

$14.49M
USD
Active NON-SBIR/STTR RPGS
Functional roles of DDX41 in the homeostasis of G quadruplexes in erythropoiesis
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Northwestern University At Chicago United States 2024 – 2029

Project Summary Increased evidence started to show that many germline mutations predispose individuals to myeloid neoplasms, including myelodysplastic syndromes (MDS). One of these...

$4.75M
USD
Active NON-SBIR/STTR RPGS
4/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
NATIONAL INSTITUTE OF MENTAL HEALTH University of Alabama At Birmingham United States 2024 – 2029

PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...

$3.66M
USD
Active NON-SBIR/STTR RPGS
Determining the mechanisms of extracellular vesicle release, function, and clearance
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES Texas A&M Agrilife Research United States 2024 – 2029

Project Summary/Abstract Cells release extracellular vesicles (EVs) that carry signals to alter cell fate or metabolism, promote invasive behavior, or modulate the immune response....

$3.67M
USD
Active NON-SBIR/STTR RPGS
PFAS increases susceptibility to infection-mediated PTB
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCE... Wayne State University United States 2024 – 2029

PROJECT SUMMARY Preterm birth (PTB) and related intrauterine growth retardation (IUGR) affects 15 million babies a year globally (~11% of births) and is linked to chronic diseases...

$5.34M
USD
Active Government and Civil Society
Female Leadership for Financial Literacy
U.S. Agency for International Development Centar Za Odrivi Razvoj Bosnia and Herzegovina 2024 – 2027

AN EDUCATION AND MENTORSHIP PROJECT TO IMPART FINANCIAL LITERACY AND LEADERSHIP SKILLS TO YOUNG GIRLS IN NUMEROUS MUNICIPALITIES.

$51.6K
USD
Active Government and Civil Society
Information Redacted
U.S. Agency for International Development Enterprise - United States Redacted Bosnia and Herzegovina 2024 – 2029

Information Redacted

$21.5K
USD
Active Government and Civil Society
Victims rights have no price!
U.S. Agency for International Development Vatra Psycho-Social Center Albania 2024 – 2028

INCREASE FULL ACCESS TO JUSTICE, IDENTIFICATION AND PROTECTION OF VICTIMS OF HUMAN TRAFFICKING ACCORDING TO THE RIGHTS DEFINED IN THE LEGISLATION.

$45K
USD
Active Government and Civil Society
Strengthening Community Resilience against CVE in Pogradec and Vlora
U.S. Agency for International Development Enterprise - Non United States Other Albania 2024 – 2027

To empower youth in Pogradec and Vlora to counter violent extremism through leadership, education, community engagement and policy influence, fostering resilience and promoting pea...

$55.5K
USD
Active HIV/AIDS
Global AIDS: Strengthening Laboratory Systems to improve access to quality and HIV/AIDS services through partnerships and innovation in PEPFAR supported countries
Department of State African Field Epidemiology Network Angola 2024 – 2029

The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world.This hi...

$18.03M
USD
Active Government and Civil Society
AML/CFT Conference June 17-19 Information Redacted .
Department of State Enterprise - United States Redacted Belize 2024 – 2029

DESCRIPTION MASKED FOR PII PURPOSES

$4.8K
USD
Active Government and Civil Society
Technical Assistance for Revenue Policy and Administration - Sri Lanka 02
Department of the Treasury Personal Services Contractors - Treasury Sri Lanka 2024 – 2027

Technical Assistance for Revenue Policy and Administration - Sri Lanka 02

$344.1K
USD
Active Other Multisector
DADIE Etienne
Department of State Enterprise - Non United States Other Cote d'Ivoire 2024 – 2027

DADIE Etienne

USD