Browse All Grants
606,025 grants found
Showing 27,061 – 27,080 of 606,025 grants
MSPP Application
NOT APPLICABLE no Abstract
High-resolution approaches to dissect the role of subcellular redox circuits in vivo
Project Summary Metastasis is the leading cause of death for cancer patients. Oxidative stress, characterized by excessive exposure to reactive oxygen species (ROS), kills most met...
Development and Evaluation of Technology and Safety Supports for Individuals with Intellectual and Developmental Disabilities to Independently Use Driverless and Driver Supported Ridehailing Services
Development and Evaluation of Technology and Safety Supports for Individuals with Intellectual and Developmental Disabilities to Independently Use Driverless and Driver Supported R...
Metalloproteins: evolution, catalysis and material design
Project 1: Recently, we have demonstrated for the first time the predictive link between NMR chemical shift perturbation, protein dynamics and probability of finding productive mut...
NIHR Short Placement Award for Research Collaborations 2023
Training Award
Neural mechanisms of anxiety during early and protracted abstinence in alcohol use disorder
Project Summary: Alcohol use disorder (AUD) is a chronic, neuropsychiatric illness characterized by frequent relapses, driven in part by anxiety during abstinence. Identifying the...
Cardiovascular and thermoregulatory consequences of severe burn injuries
Within the United States, 500,000+ individuals are enduring the long-term consequences of severe burn injuries covering 20% or more of their body surface area, with upwards to 11,0...
Essential functions of OGT in host defense mechanism
Project Summary Cellular metabolism instructs immune cell functions in both physiological and disease conditions. Activation of immune cells in response to invading pathogens induc...
3/5- Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Delineating the mechanisms of filopodia-mediated intracellular delivery of siRNAs via peptide carriers towards the development of a molecular targeted therapy for oral cancer
The use of exogenous nucleic acids has great potential for therapeutic applications in numerous diseases, including cancer. However, the delivery of nucleic acids is challenging, a...
Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?
Project Summary Increasing evidence suggests that maternal inflammation/infection-induced immune activation (MIA) during pregnancy can lead to sustained, long-lasting changes in im...
Linkages between HIV/STI prevention and syndemic behaviors in high risk youth: Common factors and unique pathways
ABSTRACT Current data continue to reflect that the likelihood of being infected with HIV is elevated among certain groups who have historically been less well represented in resear...
Drexel DREAM (Diversity, Research, Experiential Learning, Aging Science, and Mentorship) Scholars Program
Drexel University proposes to establish a robust and innovative program, Drexel DREAM (Diversity, Research, Experiential Learning, Research Skills and Aging Science, and Mentorship...
Efficacy and Mechanisms of Media and Storybook Interventions to Promote Children’s Early Literacy Skills via Caregiver Engagement
Project Summary/Abstract This project aims to determine whether a media-based intervention targeting low- socioeconomic status (SES) preschoolers and their caregivers can improve c...
ER-phagy regulation of immune response: mechanisms and significance
Despite increased clinical awareness, sepsis remains a leading cause of death and high healthcare costs worldwide. Sepsis is a life-threatening condition characterized by an exagge...
Role of TAM receptors in modulating humoral immunity against parasitic infections
ABSTRACT Unlike many infectious diseases, naturally acquired immunity against Plasmodium do not represent durable sterilizing immunity. While the gradual acquisition of protective...
A Prospective Study of Persistent Symptoms of Lyme Disease
ABSTRACT: OVERALL Despite years of research, there is no diagnostic test for post-treatment Lyme disease syndrome (PTLDS); there is no consensus treatment for PTLDS; there is no ag...
Administrative Core
ABSTRACT: ADMINISTRATIVE CORE The Administrative Core will be based in the Department of Molecular Biology and Microbiology at the Tufts University School of Medicine and will prov...
Clinical Coordination Core
ABSTRACT- CLINICAL COORDINATION CORE The Clinical Coordination Core (CCC) provides oversight for efficient and optimal enrollment of patients with early Lyme disease as manifested...
Diagnostics Core
ABSTRACT- DIAGNOSTIC CORE The Diagnostics Core provides comprehensive laboratory testing for Lyme disease in a CLIA-certified clinical laboratory setting. Its purpose is to provide...