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Novel methods for detection of mosaic chromosomal alterations
Project Summary Somatic mosaicism results from the accumulation of mutations over time, leading to a unique genotype in every cell. These mutations can be as small as a single base...
Using digital photovoice to explore the relationships between social media content and suicidality among transgender adolescents
Project Summary/Abstract Social media has a complex influence on mental health. It can contribute to bullying and harassment, which may result in loneliness, depression, and suicid...
Characterization and Digital Phenotyping of Migraine and Affective Disorders during Hormonal Fluctuations across the Life Course
PROJECT SUMMARY/ABSTRACT Approximately 1 in 3 reproductive aged women and girls suffer from migraine, the most disabling disease of this demographic worldwide. Affective disorders...
Ovarian Steroid Effects on Mood and Sleep Across the Adolescent Menstrual Cycle
PROJECT SUMMARY/ABSTRACT After menarche, females are twice as likely to develop depression and sleep problems than males. Ovarian steroids have been hypothesized to play a role, bu...
Mentoring in Youth Suicide Research
Abstract I am a clinical psychologist at Massachusetts General Hospital (MGH) and an Associate Professor at Harvard Medical School. I also serve as Director of Suicide Research in...
Defining Actionable Opportunities in Malignant Phyllodes via Genomic Profiling
ABSTRACT Malignant phyllodes tumors (MPT) are extremely rare primary breast cancers, which are globally understudied due the infrequency of the diagnosis and to the unfamiliarity w...
Integrative proteogenomics for elucidation of tumor-specific cell surface proteomes in ultra-rare cancers
Project Summary Despite advances in treatment, sarcomas like rhabdoid tumors and desmoplastic small round cell tumors (DSRCT) remain challenging, with frequent therapy resistance a...
Characterizing the regulatory roles of microRNA on mitochondria in the mammalian CNS
PROJECT SUMMARY/ABSTRACT Neuronal tissue is the most energy consumptive tissue type of the entire body, and as such, depends heavily on the health and proper regulation of its mito...
Inflammation and EGFR crosstalk in HNSCC Therapy
Project Summary Given the importance of oncogenic epidermal growth factor receptor (EGFR) signaling for tumor cell proliferation in head and neck squamous cell carcinoma (HNSCC), w...
Investigating Mentalizing as a Cognitive Strength and Protective Factor Among Youth Impacted by Structural Inequality
PROJECT SUMMARY/ABSTRACT More than 10 million youth in the United States live in poverty and experience structural inequality. Experiences organized by structural inequality (e.g....
Insulin and Immune Mechanisms in Obesity-Induced Renal Disease
Prepubertal childhood obesity (PPO) has emerged as an epidemic and major health problem in the United States. Recent studies suggest that PPO is associated with increased risk of r...
Molecular dynamics of the HBV capsid to advance the search for antivirals
The hepatitis B virus (HBV) capsid is a promising therapeutic target that could contribute to the elimination of viral hepatitis as a major public health threat. The capsid is an i...
Project 1
PROJECT SUMMARY/ABSTRACT For multiple subtypes of breast cancer, Black patients endure poorer outcomes than White patients. There are many contributing factors, including socioecon...
Oocyte mitochondrial activity regulates embryo telomere reprogramming
PROJECT SUMMARY Telomeres, the repetitive DNA at the ends of chromosomes, shorten during every cell division except in very exceptional circumstances; in particular, rapid telomere...
Pathobiology of autoimmune-mediated diffuse podocytopathy
Project Summary/Abstract Minimal change disease and primary focal and segmental glomerulosclerosis are morphologic expressions of a diffuse podocytopathy of to date unknown cause,...
Glycinergic inhibition in the ventral brainstem
Project Summary The autonomic nervous system (ANS) regulates multiple aspects of energy homeostasis including food intake, energy expenditure, lipid metabolism, and glucose homeost...
Investigating the role of gut-derived extracellular vesicles in PTSD following TBI
Abstract Veterans and the general public with traumatic brain injury (TBI) have a high risk of developing posttraumatic stress disorder (PTSD) and other psychiatric disorders, such...
Bacteriophage strategies to lyse bacterial cells
Project Summary Bacteriophage, or phage, infect and kill bacterial cells. At a programmed time, phage use a tailored suite of proteins to release newly built virions by lysing the...
3/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer
PROJECT SUMMARY / ABSTRACT: Survival with end-stage kidney disease (ESKD) has improved in the last decade alongside the trend of an aging population with greater risks, including c...