Browse All Grants
606,025 grants found
Showing 27,021 – 27,040 of 606,025 grants
Synergizing Common Fund Data from MoTrPAC and LINCS for the Discovery of Novel Exercise Mimetic Drugs
PROJECT SUMMARYExercise represents one of the most powerful and beneficial interventions for health and wellness, though patients with and without chronic disease struggle to exerc...
Development of a first-in-class complement inhibitor for treating complement-mediated hematologic diseases
ABSTRACT Excessive complement activation causes many diseases especially hematologic diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and autoimmune hemolytic anemia (AIH...
GeneSight: Advancing Insights into Complex Genetic Traits through CFDE-Enhanced Knowledge Graphs
Abstract: Unraveling the molecular mechanisms that link SNPs and genes identified in GWAS studies to the disease is a challenge that must be overcome to translate these genetic dis...
Leveraging Heterogenous Common Fund Data Sets and Beyond for Identifying Lung Cancer Subtypes
Scientific Abstract As the leading cause of cancer death in the United States, lung cancer accounts for about 20% of all cancer deaths. While there are two major types of lung canc...
Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM)
PROJECT SUMMARY/ABSTRACT More than 24,000 children develop acute respiratory failure (ARF) and require invasive mechanical ventilation (MV) – an intrusive, painful, yet lifesaving...
Implementing and Personalizing Best-In-Class Opioid-sparing Pain Management for Major Inpatient Surgeries in Children
PROJECT SUMMARY: The multicenter PRECISE Analgesia (Prospective Randomized Evaluation of Analgesia for Cardiac and Idiopathic Scoliosis Spine Fusion Elective Surgery in Children) t...
Trans Nasal Transesophageal Echocardiography
Project Summary: Transesophageal echocardiography (TEE) is an essential diagnostic tool in cardiology. There are over one million TEEs performed annually in the United States. A ma...
Efficacy of intravenous sub-dissociative ketamine versus intravenous morphine in children with acute pain.
Project Summary Pain is one of the most common reasons for children to visit an emergency department (ED) and is associated with short- and long-term consequences when inadequately...
Immunology of Post-Treatment Lyme Disease Syndrome
ABSTRACT: Project 2, Immunology of Post-treatment Lyme Disease Syndrome Similarities between symptoms of Post-Treatment Lyme Disease Syndrome (PTLDS) and symptoms seen with fibromy...
Shapeshifting Cyclic Peptides as Single Molecule Polypharmacological Drugs
SUMMARY/ABSTRACT For many years, scientists have been trying to find new therapeutic drugs. However, small molecules are still imperfect tools for influencing human physiology. The...
Understanding Sensorimotor Control Through Realistic Neuro-Biomechanical Simulation
Summary/Abstract The brain evolved to move the body, i.e., to implement sensorimotor control. Understanding the brain, then, is inextricably linked to understanding how it coordina...
THE ROLE OF PARACINGULATE SULCAL MORPHOLOGY IN AFFECTIVE NETWORK CONNECTIVITY
PROJECT SUMMARY The cingulum bundle (CB) is a major white matter fiber system mediating connectivity of the affective network. As mood monitoring and regulation are controlled by t...
Effects of Internal State on Social and Non-Social Decision Making in the Non-Human Primate Prefrontal Cortex
Abstract. Physiological and psychological factors, such as homeostatic needs or emotional state, underlie the decisions we make. A growing body of evidences suggests that these fac...
2024 NASDA Annual Meeting
PROJECT SUMMARY/ABSTRACT The objective of NASDA’s 2024 Annual Meeting is to provide information on current and emerging feed and food safety issues impacting agriculture, and to bu...
The Annual Food Safety and Defense Conference, held in the District of Columbia, is an educational conference and collaborative effort with stakeholders in the District.
2201 Shannon Place SE Washington, DC 20020 Phone: (202)738-7013 Fax: (202) 535-1359 Email: [email protected] Website http: www.doh.dc.gov April 12,2024 June 30,2024 Coming out of...
CRCNS: Dissection and control of cognitive thalamocortical dynamics
PROJECT SUMMARY (See instructions): Cognitive flexibility, the ability to mentally switch between different thoughts and action plans, is critical for survival in a rapidly changin...
Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy
ABSTRACT Over 38 million people worldwide are living with HIV, and the non-communicable complications of HIV infection are a significant global health concern. People with HIV (PWH...
Retinal biomarkers in monogenic vascular cognitive impairment and dementia
Project Summary/Abstract The project will enroll 180 persons with the autosomal dominant gene for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoenceph...
Phase 2a/2b Study Emapalumab: A Window of Opportunity in Pediatric Aplastic Anemia
Abstract Acquired aplastic anemia (AA) is a life-threatening disorder caused by an autoreactive T-cell mediated destruction of hematopoietic stem cells resulting in the inability t...
Cutting-edge, Customized, and Comprehensive (CCC) HIV capacity building for Vietnam and Thailand
ABSTRACT Women living with HIV (WLWH) in Vietnam face multifaceted vulnerabilities where HIV stigma and gender disparities intersect with challenges stemming from a patriarchal, fa...