Browse All Grants
606,025 grants found
Showing 27,001 – 27,020 of 606,025 grants
1/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage
PROJECT SUMMARY Osteoarthritis is a leading cause of disability in the US affecting almost 30 million people at an annual cost of $128 billion. Initiation of osteoarthritis is tied...
Role of cholesterol in the pathogenesis of hepatic encephalopathy
Liver cirrhosis results from long-term continuous damage to the liver leading to irreversible buildup of scar tissue impairing liver function. Cirrhosis can occur as a consequence...
Preclinical assessment of a novel compound for treating radiation-induced oral mucositis
Project Summary Inflammation and ulceration of mucosal tissue, called mucositis, is a severe side effect of many common treatments in oncology, including chemo- and radiotherapy. M...
5/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
A Multi-level Intervention to Reduce Total Thyroidectomy Overuse for Low-Risk Cancer
PROJECT SUMMARY The majority of patients with low-risk thyroid cancer undergo total thyroidectomy – the riskiest treatment option. Safer, less invasive alternatives offer patients...
2/5-Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
PROJECT SUMMARY The onset of a first episode of psychosis (FEP) in late adolescence or early adulthood often leads to lifelong disability. Timing and precision of treatment are of...
Digital Interventions to Study and Influence the Alcohol-Atrial Fibrillation Connection
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Alcohol is the most commonly consumed drug in th...
Multi-method investigation of social facilitation of alcohol effects and alcohol misuse in young adults
PROJECT SUMMARY Young adulthood is a critical period for alcohol initiation and changes in alcohol use patterns, including increased risk for alcohol misuse and alcohol use disorde...
Optimizing Preimplantation Kidney Transplant Biopsy Interpretation with Artificial Intelligence Assistance - Resubmission - 1
PROJECT SUMMARY Less-than-ideal kidneys recovered from deceased donors continue to be discarded at a rate of 40-50%, but evidence shows that many discarded kidneys could have yield...
Hepatic insulin resistance integrates T2D and NAFLD
This proposal investigates mechanisms that combine T2D (type 2 diabetes) with NAFLD (non-alcoholic fatty liver disease), which progress during chronic hepatic IR (insulin resistanc...
Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis
Project Summary A role for B-cells in multiple sclerosis (MS) pathogenesis has been implicated by clinical, histopathologic and immunologic studies. The precise role they play in p...
Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regi- men, including daily insulin administration/...
Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic Biomarkers
Project Summary: Mitral valve prolapse (MVP) is a common valvulopathy affecting 2-3% of the population and nearly 200 million individuals globally. While it is often benign, a subs...
Common Fund Gene Utility Compendium: A Systems Biology Resource to Explore Tissue-Specific Functional Genes and Druggable Genomes
PROJECT SUMMARY Tissue-specific genes are underutilized as disease targets. Tissue-specific genes show narrow expression, play key roles in maintaining tissue homeostasis and are t...
Expanding Genomic Data Science Access via Cloud Computing and Dynamic Learning Modules
Project Summary The advent of high-throughput genomics and associated data science technologies has enabled genome-based decisions to improve human personal and public health. The...
Ultra-high resolution 3D genome maps for multiple human tissues
Abstract The diversity of human tissues and cell types is controlled by differential regulation of gene expression. Enhancers are the primary units of gene expression control in hu...
Pilot trial comparing transpyloric to gastric feeding in very preterm infants with bronchopulmonary dysplasia
PROJECT SUMMARY/ABSTRACT Bronchopulmonary dysplasia (BPD), or infant chronic lung disease, is among the most devastating complications of preterm birth. BPD affects half of survivi...
Variant impact prediction on Common Fund data sets towards drug repurposing for rare genetic diseases
PROJECT SUMMARY Despite advances in our understanding of rare genetic diseases and their causes, only 8% of these diseases have targeted drugs. Much of this arises from the disconn...
Toward Deep Learning Techniques for Cell-Type and Spatial Resolution Estimation of Regulatory Networks
Understanding and decoding the intricacies of gene regulatory networks is crucial in genomics for insights into gene expression and cellular functions. Traditionally, research in t...