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606,025 grants found
Showing 26,981 – 27,000 of 606,025 grants
Extracellular vesicle-dependent RNA signaling in metabolism
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.In conventional metabolic signaling, secreted pr...
Dissecting enhancer function through integrative genomics
PROJECT SUMMARY Enhancers are non-coding regulatory elements that directly involved in modulating cell-type-specific gene transcription. Dissecting enhancer function provides criti...
Uncovering Heterogeneity in Individual Treatment Responses via Causal Machine Learning
PROJECT SUMMARY/ABSTRACT Clinical recommendations for the management of diseases are mostly based on the average treatment effects observed in randomized controlled trials. However...
Sickle Cell Disease Pain Analgesia And Integrative Network
PROJECT SUMMARY/ABSTRACT Our goal is to build Sickle Cell Disease Pain Analgesia and Integrative Network (SCDPAIN) as an innovative, dynamic and interactive platform that will adva...
Evaluating a Multilevel Intervention to Increase Colonoscopic Follow-up after Abnormal Stool-based Colorectal Cancer Screening in a Community Safety-Net Setting
Project Summary/Abstract Colorectal cancer (CRC) is the second most common cause of cancer-related mortality in the United States (U.S.). Although several effective prevention and...
1/5 Clinical Outcome Prediction of Psychosis from EHRs (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
Zwitterionic polyethylene glycol for therapeutic delivery
Project Summary Biologic drugs and nanomedicines with conjugated polyethylene glycol (PEG) show extended circulation in the blood, increasing therapeutic efficacy. The U.S. FDA has...
Scalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seq
Although numerous genes and loci associated with autism spectrum disorder and neurodevelopmental delay (ASD/NDD) have been identified through genome sequencing efforts, the precise...
Alcohol impairs the HSPC response to septic infection
Project Summary/Abstract Alcohol abuse increases the host risk of developing serious infections, particularly septicemia/sepsis. Neutrophil granulocytes constitute the first line o...
Planning grant for clinical trial of implicit bias mitigation training for clinicians
Hypertension is a leading cardiovascular disease risk factor in the US and a leading cause of stroke, kidney disease, and heart failure. Compared to White individuals, it is more p...
Light therapy for obsessive-compulsive disorder: A circadian medicine approach
PROJECT SUMMARY/ABSTRACT Obsessive-compulsive disorder (OCD) is characterized by intrusive, distressing thoughts (i.e., obsessions) and repetitive behaviors (i.e., compulsions) and...
Endometrial immune microenvironment dysfunction in endometriosis pathobiology
PROJECT SUMMARY Endometriosis, a debilitating chronic disease, affects around 10% of reproductive age women worldwide, severely impacting quality-of-life. Unfortunately, there is o...
Cloud immersion and the future of tropical montane forests
Tropical montane forests are unique biodiversity rich ecosystems which provide water to tens of millions of people, alongside other services such as carbonsequestration. Unfortunat...
Leeds Beckett University and EPG Business Limited KTP23_24 R4
To develop and embed behaviour change theory and practice and robust impact measurement into digital and non-digital education platforms and services that support gambling harm red...
Scaling and Extending Quantum Lidar for Methane (SEQLM)
Manmade methane emissions cause 25% of global heating but also present a golden opportunity to decisively act on the climate crisis. About 40% of these emissions come from leaks fr...
University of Brighton and Swim Trek Ltd KTP 23_24 R4
To develop a novel environmental, social and economic impact framework for identifying and capturing adventure tourism data and implementing novel methodologies for mitigating (off...
University of Newcastle upon Tyne and Ethical Healthcare Limited KTP 22_23 R4
To improve management capability and internal culture enabling sustainable business growth via internal process optimisation and enhanced market exploitation in the UK health and c...
Collaboration arena - Resource-efficient and circular aggregates of the future
Purpose and goal: The project aims to collectively increase resource management and create safe, efficientcircular flows of rock material for construction work. The goal of the pro...
Genetic Map of the Mammalian Cell Response to Environmental Stress
A wide variety of environmental stressors, from pesticides to common anticancer chemotherapies, result in protein damage. This damage underlies diseases such as cancer and neurodeg...
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
PROJECT SUMMARY/ABSTRACT Lynch syndrome (LS), the most common inherited cause of colorectal cancer (CRC) affecting ~1.2 million Amer- icans, carries 3-8x higher lifetime CRC risk t...