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606,025 grants found
Showing 25,741 – 25,760 of 606,025 grants
Social Visual Attention and Language Development in Autism: Leveraging Infant-Directed Speech and Song to Identify Multimodal Mechanisms of Communication
Language ability is a strong and consistent predictor of outcomes for individuals on the autism spectrum (ASD). ConsequenUy, understanding key predictors and mechanisms underlying...
Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's Disease
Alzheimer's disease (AD) remains uncurable. The complex, and diverse, neuropathology suggests that AD may actually represent not a single disease, but a family of diseases tha...
Therapeutic targeting mesenchymal transition in newly diagnosed and recurrent GBM
PROJECT SUMMARY IDHwt glioblastoma (GBM) patients still live an average of ~15-months, despite advances in multimodal therapy. A central issue confounding treatment is the heteroge...
Gender and sex dimorphism in age-related knee osteoarthritis
ABSTRACT As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes a...
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
PROJECT SUMMARY/ABSTRACT While it is widely acknowledged that Alzheimer’s disease and related dementias (AD/ADRD) have an extended preclinical phase, there are sparse data on the c...
Aversive midbrain glutamatergic regulation of the locus coeruleus during opioid withdrawal
Fentanyl and other synthetic opioids are killing thousands of Americans each year. The overall goal of this research is to better understand the role of the primary central noradre...
Functional implications of structural heterogeneity in a viral RNA translation initiation element
PROJECT SUMMARY RNA viruses are an emerging health threat, evolving rapidly to proliferate and spread. Within these viruses are structured RNA elements that facilitate infection an...
Utilization and Assessment of Ancestry- Informed Genomics in Admixed Populations: Recommendations for Precision Medicine Initiatives
PROJECT SUMMARY/ABSTRACT Approximately 50% of adults in the United States have at least one chronic disease, and minority populations have a disparate burden compared to individual...
The Role of c-ABL in Mediating TIE2 Signaling and Formation of Venous Malformation
PROJECT SUMMARY/ABSTRACT Venous malformations (VMs) are vascular lesions with abnormally enlarged vessels that are disfiguring, painful, and have complications such as bleeding and...
Community-derived Multilevel-Multicomponent Nutrition Intervention to Reduce Food Access Disparities -FRESH-EATS
PROJECT SUMMARY The prevalence of diet-related diseases and health conditions such as obesity, diabetes, and cardiovascular diseases are higher among Black/African-Americans (AA) i...
Annual Conference of the International Society of Addiction Journal Editors: Preparing an underrepresented workforce for editorial board leadership
ABSTRACT/SUMMARY The overall goal of this 5-year R13 grant is to address the substantial underrepresentation of knowledge production and dissemination by individuals from underrepr...
Evaluating a tobacco harm reduction strategy among clients enrolled in substance use disorder treatment
PROJECT ABSTRACT The prevalence of cigarette smoking among individuals with substance use disorders (SUD) is nearly three times higher than the prevalence of smoking among the gene...
Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular Delivery
Abstract The overall goal of this proposal is to develop novel biomaterials for intracellular therapeutics delivery. While messenger RNAs (mRNAs) are recognized as promising candid...
Theoretically Informed Behavioral Intervention to Enhance QOL and Prevent HIV-related Comorbidities in Ethnic and Racial Sexual Minority Men
Project Summary Black and Latinx gay and bisexual men are at highest risk of comorbid conditions resulting from HIV. Cardiovascular disease has become the leading contributor to mo...
Phase II Evaluation of Tirzepatide in Adults with Alcohol Use Disorder and Overweight or Obesity
PROJECT SUMMARY Alcohol use disorder (AUD) and overweight/obesity (OOB) are highly prevalent conditions that contribute substantially to global disease burden. Alongside recent inc...
Hair-greying and melanocytic regulation of BCL2 in a non-model organism
Project Summary/Abstract Hair-greying is an early and visible sign of aging with important psychosocial, commercial, and biologic implications. The underlying mechanisms of hair-gr...
Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging
PROJECT SUMMARY / ABSTRACT A fundamental challenge in our rapidly aging society is how to extend healthspan, or maintain robust fitness without major diseases. The circadian clock,...
Deep TMS Neuromodulation of Neural Circuits Associated with Stimulant Use Disorder
ABSTRACT Background: Converging lines of evidence suggest that neuromodulation of the neural circuits underlying methamphetamine use disorder (MUD) and subsequent relapse may be an...
Comprehensive Telehealth at Syringe Service Programs to Engage People Who Inject Drugs into the HIV Care Continuum
PROJECT SUMMARY Biomedical breakthroughs over the past 30-years have dramatically improved treatment and prevention of HIV, hepatitis C virus (HCV), and opioid use disorder (OUD)....
Expansion of an established breeding SPF Program at CPRC
SUMMARY The rhesus macaque (Macaca mulatta) is the most commonly used nonhuman primate model in biomedical research. Nonhuman primate models are of growing importance for HIV/AIDS-...