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606,025 grants found
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CTN - Evaluation of SeMaglutide as an Adjunct to buprenorphine treatment for the treatment of opioid use disorder: A pragmatic Randomized placebo-controlled Trial (SMART)
Evaluation of SeMaglutide as an Adjunct to buprenorphine treatment for the treatment of opioid use disorder: A pragmatic Randomized placebo-controlled Trial (SMART) ABSTRACT/PROJEC...
Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in Uganda
As over 25 million people living with HIV (PWH) in sub-Saharan Africa (sSA) reach older age, determining their risk for and causes of mild cognitive impairment (MCI) and Alzheimer’...
CTN - Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target tr
Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populatio...
The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network
CTN-0121 UM Supplement Request PROJECT SUMMARY/ABSTRACT This application is to request supplement funds for FY25 for CTN-0121: Integrated Care and Treatment for Severe Infectious D...
Novel Paxillin-FAK Inhibitors for the Treatment of Liver Fibrosis
Abstract Chronic liver diseases like metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and viral hepatitis afflict more than 4.5 million Ameri...
Low-threshold buprenorphine treatment at syringe services programs: a Type I hybrid effectiveness-implementation trial” (CTN concept under development)
Tookes’ Supplement Request Abstract Most Americans with OUD remain out-of-treatment. Over the past three decades, rates of opioid use, OUD and overdose have skyrocketed. Medication...
Financial Impact of Support and Care in Alzheimer's disease and Related Dementias (FISCAL)
Family caregivers provide much of the support to people with Alzheimer’s disease (AD) and AD-related dementias (ADRD) living in the community. As a result, caregivers for people wi...
Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments
Oral cancer is the 6th most common cancer, mostly tongue oral squamous cell carcinoma (OSCC). Surgery and radiation treatments result in severe quality of life issues, tissue stiff...
Social Connectedness, Loneliness, and Health Among Aging Black Sexual Minority Men
SUMMARY/ABSTRACT Health disparities affecting older adults reflect disparities across the life span with the added burden of ageism. Black sexual minority men (BSMM) in particular,...
Role of Home-based Medical Care and Telemedicine in Care and Outcomes of Dementia and Coexisting Conditions in Public and Private Medicare
Home-based medical care (HBMC) is essential for the growing population of community-living persons with Alzheimer's Disease and Related Dementias (ADRD). People living with AD...
The Building Resistance Against Viral Entities (BRAVE) Innovation Center
SUMMARY The introduction of highly pathogenic avian influenza (HPAI) virus of the Guangdong H5N1 lineage has resulted in severe disease outbreaks with widespread mortality in wild...
Development and validation of pain models in food animals
Development and validation of pain models in food animals Project Summary Each year, more than 65 million piglets, 1 million goats and 15 million calves in the U.S. undergo painful...
Controlling Histomonas meleagridis transmission in turkey flocks
PROJECT SUMMARY/ABSTRACT Histomonas meleagridis is an intracellular protozoan that can cause severe morbidity and mortality in birds, particularly turkeys. Infection can lead to a...
UC Davis IGA Innovation Center
We propose to establish the “UC Davis Intentional Genomic Alteration (IGA) Innovation Center” focused on research on IGAs in major livestock species to advance the use of gene edit...
Uncovering novel heme chemistry in microbial systems
Project Summary In nature, metalloenzymes make up approximately one third of the known enzymes and play central roles in biological processes such as photosynthesis, respiration, a...
Mechanisms that regulate erythroid differentiation of hematopoietic stem cells
Hematopoietic stem cells (HSCs) are capable of regenerating the entire hematopoietic system. This capacity is fully unleashed upon bone marrow transplantation, however, recent stud...
Interdisciplinary Summer Institute on the Analysis of Complex, Large-Scale Longitudinal Data
Project Summary Contemporary large-scale NIH initiatives have led to the emergence of many high-quality publicly available longitudinal datasets that that include complex data of v...
ABCD-ReproNim: An Educational Program for Responsible and Reproducible Analyses of Complex, Large-Scale Data
PROJECT SUMMARY/ABSTRACT This project supports the ABCD-ReproNim Educational Program, which provides research training in responsible and reproducible analyses of data from the Ado...
Frameworks: Deep Learning Cyber-Infrastructure for the Exploration of High Dimensional Multimodal Data
The BisQue Deep Learning (BDL) cyberinfrastructure (CI) project is set to transform scientific research across multiple fields, including materials science, environmental science,...
Crossing the Innovation Valley of Death: Democratizing Data and Artificial Intelligence for Research Administration
This project aims to significantly enhance post-award research administration by developing open-source tools that integrate artificial intelligence (AI) and data science. Research...