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606,025 grants found
Showing 25,701 – 25,720 of 606,025 grants
Microdosing Implant to Mitigate Depression Associated with Opioid Use Disorder
Project Summary/Abstract The opioid epidemic is one of the major crises of our time, causing over 80,000 opioid-related overdose deaths per year in the United States and levying ma...
Speech, Language, and Motor Skills in Late Talkers
PROJECT SUMMARY Predicting language outcomes in children referred for early language concerns is a longstanding clinical and scientific challenge that often results in the delayed...
Extended amygdala corticotropin-releasing factor circuits mediating sex-specific impacts of early life stress on alcohol sensitivity
PROJECT SUMMARY/ABSTRACT Exposure to adverse childhood experiences (ACEs), such as abuse or neglect, is a powerful risk factor for the development of alcohol use disorder (AUD) in...
Human induced pluripotent stem cell-derived models of SLC6A1-related epileptic encephalopathy
PROJECT SUMMARY/ABSTRACT Myoclonic Atonic Epilepsy (MAE), a rare developmental and epileptic encephalopathy (DEE) characterized by frequent severe seizures, developmental delay, an...
Midwest DDRCC Alliance Conference (Hosted by the Cleveland DDRCC)
PROJECT SUMMARY The goal of this application is to obtain additional funds for the Midwest Digestive Disease Research Core Centers (DDRCC) Alliance Conference to be held during in...
Neural and Behavioral Representations of a Transdisciplinary Model of Craving in Normative and Substance Use Populations
Project Summary Craving, the intense desire for drugs, is a pivotal cause of relapse in substance use disorders and is known to grow during abstinence known as the incubation of cr...
Investigating Visual Attention Mechanisms During Emotional Inferences
Project Summary Humans move their eyes toward relevant information when making decisions, especially when making social inferences (e.g. inferences on emotion, trustworthiness, dan...
Time-dependent changes in chloride homeostasis are a mechanism of plasticity critical for learning
ABSTRACT The mechanisms underlying how rewards are learned, and how they translate into behavior have been a subject of interest to researchers and scientists since Pavlov’s classi...
Transcription, Chromatin, and Epigenetics in Aging
SUMMARY The goal of this FASEB meeting “Transcription, Chromatin and Epigenetics in Aging” is to cover innovative topics in the roles epigenetic mechanisms play in the regulation o...
Mapping neural targets and advancing neuromodulation techniques for disorders of consciousness
Project Summary/ Abstract The researcher's central career goal is to become an independent researcher investigating disorders of consciousness (DoC), with a specific emphasis...
Fostering Meaningful Use of Common Fund Data
Abstract To help ensure that Common Fund Data Ecosystem (CFDE) data assets, data tools, and resources are findable, accessible, interoperable, and reusable (FAIR), the project will...
Leveraging Consanguinity in Pakistan to Uncover the Genomic Architecture of Alzheimer's Disease: Feasibility Study with ENIGMA-PAK
PROJECT SUMMARY/ABSTRACT Currently, there are almost 55 million people living with dementia worldwide, and this number is estimated to double every 20-years, reaching about 131.5 m...
Dissecting the interaction between sex and APOE genotype in modulating AD risk
Although the majority of AD patients are sporadic (SAD), numerous studies have implicated biological sex and variation in the Apolipoprotein E (APOE) gene as two of the strongest f...
A friend in my pocket": mHealth intervention to reduce overdose risk among people who engage in polysubstance use
Polysubstance use is the defining characteristic of the fourth wave of the overdose (OD) epidemic. The proposed study will adapt and test a smartphone-based mobile health (mHealth)...
Dietary factors, neuroinflammation, plasma neurodegenerative biomarkers and Alzheimer’s disease in diverse cohorts
Project Summary N resubmission in response to PAR-22-093. Prevention strategies, such as healthy sustainable diets are critical and ase-related dementia (AD/ADRD) to have a populat...
Mechanisms of Complement Activation in Traumatic Injury
Project Summary The leading cause of death from ages 1-44-years in the United States is traumatic injury, responsible for millions of hospital encounters at a cost of over $4 trill...
Measuring the Impact of Structural Gendered Racism on Black Women’s Cognitive Aging and Risk of Alzheimer’s Disease and Related Dementia: A Mixed-Methods Investigation
PROJECT ABSTRACT Disparities in Alzheimer’s disease and related dementias (ADRD) exist across race as well as sex/gender, and structural oppression is hypothesized to be an importa...
Cellular senescence as a potential sex-specific driver of small vessel disease and post-stroke cognitive impairment in late adulthood
PROJECT SUMMARY/ABSTRACT Stroke is the leading cause of long-term disability in the United States and is the third leading cause of death in women, and the fifth in men. Through im...
Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings
Project Summary/Abstract RFA-DA-24-018 Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Tre...
Development and Evaluation of a Mobile Health Intervention for Co-Morbid Opioid Use Disorder and Posttraumatic Stress Disorder During Community Re-entry
PROJECT SUMMARY/ABSTRACT Of the nearly 400,000 people with an opioid use disorder (OUD) who receive OUD treatment each year, 1 in 6 utilize residential services. Community re-entry...