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606,025 grants found
Showing 25,761 – 25,780 of 606,025 grants
Photochemical Tissue Modification for MALDI Mass Spectrometry Imaging
Project Summary/Abstract The goal of this project is to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections for mass spectrometr...
Lifelong Correction of Hereditary Tyrosinemia Type 1 and Other Monogenic Liver Diseases using Liver-specific Hydrodynamic Gene Delivery through the Biliary System
PROJECT SUMMARY Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive Inborn Error of Metabolism (IEM), characterized by the inability to metabolize tyrosine and caused by...
AVA_ AI Video-Based Mobile Application for Reliable, Accessible, and Low-Cost Fall Risk Assessments of Older Adults
AbstractFalls are a significant issue for older adults, causing physical, emotional, and financial strain. Research indicates that regular and early fall screenings can reduce fall...
Development of an Oral Pill to Mimic the Effects of Gastric Bypass Surgery
PROJECT SUMMARY Obesity is a complex disease that disrupts hormonal and metabolic pathways, increasing the risk of chronic co- morbidities like diabetes, cardiovascular disease, an...
Innovative Pneumothorax Decompression Device
Project Summary/Abstract The proposed project relates to the development of an innovative, single-operator pneumothorax decompression device that aims to improve the safety and tim...
A Hybrid Program to Prevent Substance Use Risk among Upper Elementary School Students Using a Positive Youth Development Approach
ABSTRACT This SBIR Fast-Track proposal is designed to address the urgent problems of vaping and prescription drug misuse (PDM) among youth in the U.S. There is a dearth of primary...
Regenerative peptide therapy to accelerate pressure ulcer healing
Abstract Adrenomedullin (ADM) and CGRP family peptides play pivotal roles in regulating angiogenesis, vasculogenesis, and tissue regeneration. Although wild-type ADM and CGRP impro...
Digital Aftercare Assessed: An Evaluation of the Pink Cloud Application in Post-Treatment Substance Use Disorder Support.
Project Summary This Direct to Phase II SBIR initiative aims to comprehensively validate the Pink Cloud digital platform, a groundbreaking mobile health application linked to the w...
Commercialization Readiness for Ductus Arteriosus Stent to Improve Congenital Heart Defect Mortality
ABSTRACT The technical challenges faced by pediatric cardiovascular physicians (surgeons and interventionalists alike) have long been ignored, forcing them to use devices designed...
Revolutionizing Healthcare Workforce Management: A Comprehensive Solution for Licensing Disparities and Workforce Retention in Certified Nurse Assistants (CNAs)
Abstract From 2020 to 2030, the US will need to fill a total of 7.9 million direct care job openings, from both new and existing vacancies, due to workers leaving the industry (PHI...
A System Approach to Animal-Level Antimicrobial Use Monitoring in Dairy Cattle
PROJECT SUMMARY There is a fundamental gap in our ability to monitor antimicrobial use (AMU) at the individual animal level in dairy cattle nationally. The continued existence of t...
Antimicrobial Use Data Collection in the U.S. Poultry Production System
Project Summary/Abstract Antimicrobial use (AMU) is the primary selective force behind the emergence of resistant bacteria. Improving antimicrobial stewardship (AMS) in human and a...
Bridging Critical Data Gaps in Veterinary Medicine Via Artificial Intelligence and Advanced Large Language Models to Procure Real-Time Antibiotic Use Data in Livestock, Poultry and Companion Animals
Project Summary Antibiotic resistance stands as a formidable challenge in both human and veterinary medicine, demanding comprehensive strategies to monitor and regulate antimicrobi...
Collaborative Research: Planning: CRISES: Human-Centered Early Warning Systems for Weather Hazards
Hazardous weather early warning systems disseminate timely and meaningful information about flash floods, tornadoes, and other weather hazards so that individuals, communities and...
A Universal Tool for Unravelling the Requirements for Clinically Relevant Cell-Cell Interactions via In Situ Phenotyping and Tagging of Live Cells
PROJECT SUMMARY - ABSTRACT Cell-cell interactions drive many of today’s most challenging diseases like cancer, autoimmunity, and neurological disease. Studying cell-cell interactio...
Novel retinal higher-order capillary hemodynamics imaging for detecting cerebral small vessel disease
Project Summary Cerebral small vessel disease (CSVD) is thought to be among the most prevalent central nervous system disorders and contributes significantly to vascular cognitive...
Achieving specificity in imaging neurodegeneration with visible light Optical Coherence Tomography
Abstract: Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) have different underlying pathophysiological substrates. It follows, then, that t...
Collaborative Research: NSF BSF: Disk Formation over Cosmic Time
Most of the stars that make up our home galaxy, the Milky Way, are arranged in the shape of a rotating disk. Many other galaxies in the universe today are also shaped like disks. H...
Phase 2 Study of Interferon-Gamma and Donor Lymphocyte Infusion for the Treatment of Relapsed Myeloid Malignancies after Allogeneic Stem Cell Transplantation
Project Summary/Abstract Allogeneic stem cell transplantation (alloSCT) is a potentially curative therapy for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Donor-...
Retinoblastoma Phase II Expanded Access Clinical Trial
Abstract Retinoblastoma (RB) is a micro-orphan disease intraocular cancer in infants and children (typically diagnosed between birth and 5-years of age). Approximately 250 new case...