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606,025 grants found
Showing 25,621 – 25,640 of 606,025 grants
Therapeutic Value of BNC-1 in Addressing Tau Pathology in TBI
PROJECT SUMMARY/ABSTRACT Each year, approximately 200,000 Americans aged 65 and older seek medical care for traumatic brain injuries (TBI), primarily from closed head injuries (CHI...
Helping Patients, Families, and Clinicians Make Shared Decisions about Therapies for Dementia
PROJECT SUMMARY On July 6th, 2023, the FDA approved Lecanemab-IRMB, the first drug with evidence of slowing the rate of cognitive decline through a reduction in amyloid plaques, th...
Development of an amphiphilic PET probe to detect CD206+ microglia/macrophages in Alzheimer's disease
Activated macrophages and microglia are key players in the innate response in the pathogenesis of Alzheimer’s disease (AD). They are closely associated with b-amyloid deposits in b...
The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes
PROJECT SUMMARY Socioeconomically disadvantaged young adults (SDYA) are at a disproportionately greater risk of tobacco- related illness and disease compared to non-disadvantaged y...
Feasibility study for assessing processes and outcomes related to gender affirming care
PROJECT SUMMARY In the United States (U.S.) an estimated 300,000 youth, ages 13-17-years, identify as transgender and, over the past decade, increasing numbers of youth have sought...
Intermingling of circulating B cells and cerebral spinal fluid B cells with advancing age
The broad, long term objective of this project is to elucidate the role that the B cell arm of the immune system plays in the pathophysiology of aging from the stand-point of, and...
Molecular pharmacology of xylazine at adrenoceptors: Relation to necrotic skin lesions associated with chronic intravenous administration
PROJECT SUMMARY/ABSTRACT The α2-adrenergic receptor (α2R) agonist xylazine has been used in veterinary medicine for decades owing to its anesthetic, muscle relaxant, and analgesic...
Research Advising and Mentoring Professionals for Underrepresented Peoples (RAMP UP)
Project Summary The biomedical workforce fails to represent the diverse makeup of the US population. Numerous groups, including Indigenous and those from rural backgrounds, are sig...
The mechanisms of cerebral microcirculation response to transcranial stimulation.
Transcranial alternating current stimulation (tACS) is a relatively new non-invasive electrical stimulation technique (tES) where a sinusoidal oscillating low-voltage electric curr...
Negative allosteric modulation of mu opioid receptors to reverse fentanyl overdose
Abstract Fentanyl’s high potency, facile synthesis, abuse liability, and propensity to cause profound respiratory depression via the mu opioid receptor (MOR) have combined to creat...
Novel methods for estimating adult mortality using a survey
ABSTRACT Accurate estimates of adult death rates are critical to good science and health policy. In most high-income countries, adult death rates are directly calculated since civi...
Using a Pragmatic Randomized Rollout Trial to Evaluate Implementation Strategies to Promote Smoking Treatment and Cancer Prevention for Salvation Army Clients
ABSTRACT / PROJECT SUMMARY The prevalence of combustible cigarette tobacco use remains high among socioeconomically disadvantaged Americans despite declines in the broader populati...
Expand human umbilical cord blood hematopoietic stem cells with PPAR-a agonists
Expand human umbilical cord blood hematopoietic stem cells with PPAR-a agonists Abstract Hematopoietic stem cells (HSCs) are defined by their self-renewal potential and ability to...
Estimating the treatment effect of cardiovascular medications to modify the risk for future cognitive decline in older adults
Project Summary/Abstract Candidate: I aspire to become an independent clinician-investigator working at the intersection of cardiovascular disease and aging, focused on the impact...
Elucidate Gene-environmental interactions employed by Pb in promoting ADRD in aging brains
Project Summary Alzheimer's disease and related dementia (AD/ADRD) affect a large percentage of population in the US creating a signficant health care burnden to society. A fe...
AD GxE: In vivo and in vitro modeling of gene x environment interactions
Project Summary Common genetic variants identified through genome-wide association studies have been reproducibly associated with risk for Alzheimer’s disease (AD), but the functio...
Examining the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids
PROJECT SUMMARY/ABSTRACT Several genetic variants within immune system genes like APOE, TREM2, BIN1, CR1, etc have been associated with Alzheimer’s disease (AD). There is also evid...
Aberrant protein S-nitrosylation mediates Gene-Environment Interactions in AD/ADRD
Project Summary Alzheimer’s disease (AD) and AD-related dementias (ADRD) represent the most common forms of neurodegenerative disease in patients above 65-years of age. Growing evi...
Phase II trial of avutometinib plus defactinib in RAF dimer-driven thyroid cancers
ABSTRACT/SUMMARY Two rare types of thyroid cancer currently have extremely poor outcomes. Radioiodine-refractory (RAIR), recurrent and/or metastatic (R/M) differentiated thyroid ca...
Gene Therapy for LCA5-Assocated Inherited Retinal Degeneration: Extension to Pediatric Cohorts
PROJECT SUMMARY / ABSTRACT Advances in genetics and genomics have raised hopes for the development of gene-based treatments for inherited retinal diseases (IRDs) which are single-g...