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606,025 grants found
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Expanding the Scope and Usability of Fast Voltammetric Measurements
ABSTRACT: Background-subtracted fast-scan cyclic voltammetry (FSCV) is unrivaled in its ability to monitor neurochemical dynamics. This approach permits highly localized analysis o...
6/7 PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Opioid actions on the habenulo-peduncular circuit
PROJECT SUMMARY Withdrawal is a major obstacle in overcoming opioid dependence and addiction. Identifying the neural circuits involved and how opioids modulate the activity of thos...
Social cognition in AUD recovery: Understanding trajectories, consequences, and mechanisms of change for deficits in emotion processing
Project Summary Alcohol Use Disorder (AUD) is characterized by attenuated capacities to recognize and interpret the emotional states of others. Extant cross-sectional studies have...
Interplay Between Langerhans Cells and Sensory Neurons: Impact on Wound Healing and Nociception Following Burn Injuries
PROJECT SUMMARY Effective wound care is of paramount importance for individuals who have sustained burn injuries. Wound healing is intricately associated with the sensations of itc...
Post-stroke Cognitive Impairment and Dementia
Vascular contributions to cognitive impairment and dementia are increasingly recognized as independent causes of dementia, particularly due to their high prevalence and potential f...
The function of post-translational modifications of myosin and its chaperone UNC-45 that occur with adult aging
Project Summary One of the unfortunate effects of aging is the loss of muscle mass, strength, and function, termed “sarcopenia”, when it is not associated with an underlying diseas...
Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors
PROJECT SUMMARY/ABSTRACT Evidence-based approaches to surveillance mammography for older breast cancer survivors do not exist. Data suggest a life expectancy of ~10-years is necess...
The physiological and molecular function of choline transport in health and metabolic disease
Project Summary Nutrient homeostasis in most living cells is mediated by membrane carrier proteins, which facilitate the translocation of small molecule metabolites across cellular...
Activation of deep crypt secretory cells in colonic inflammation
PROJECT SUMMARY An impaired epithelial lining is a key pathological element of numerous diseases of the colon; however, our understanding of how specific epithelial cell population...
The ADHINCRA Study: Addressing HypertensIoN Care in AfRicA
Project Summary/Abstract Innovation in chronic disease management is urgently needed to effectively control hypertension (HTN) in Ghana and Nigeria. Both countries are suffering si...
Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy
PROJECT SUMMARY Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, resulting in remarkable disease response rates. Yet, the u...
Targeting dysfunctional epithelial repair in pulmonary fibrosis
While it is generally agreed that epithelial injury is a central process in Idiopathic Pulmonary Fibrosis (IPF), differential mechanisms that determine functional repair versus dys...
Cardiovascular Effects of Inhalable Tobacco Product Dual Use
PROJECT SUMMARY The introduction of e-cigarettes (e-cigs) was portrayed by the tobacco industry, and expected by the public, to result in an alternative to smoking cigarettes that...
Spatial Transcriptomics for Investigating the Interaction between TDP-43 Proteinopathy and Hippocampal Sclerosis in Alzheimer's Disease
PROJECT SUMMARY Alzheimer's Disease (AD) stands as a formidable neurodegenerative affliction impacting millions globally. While substantial headway has been made in decipherin...
Quantitative magnetic resonance imaging of pulmonaryperfusion
Project Summary/Abstract The goal of this project is to establish a pharmacokinetic model for absolute quantification of pulmonary perfusion and microvascular parameters and valida...
A high-throughput assay to measure amyloid-β oligomer formation
Project Summary Toxic oligomers formed by amyloid-beta (Aβ) self-association are of high interest for research into the causes and treatment of Alzheimer's Disease. Studies Aβ...
Obstructive sleep apnea and glycemic dysregulation in adults with type 1 diabetes
Most adults with Type 1 Diabetes (T1D) do not achieve optimal glycemic control, and thus have increased cardiovascular risk. Obstructive sleep apnea (OSA) is a highly common sleep...
Stress and Affective Mechanisms that Relate to Inflammation in Diverse Older Men and Women
Project Summary/Abstract Prolonged, elevated inflammation is detrimental to health, with ties to disease and mortality, making prolonged, elevated inflammation an economic burden a...
Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults with Type 1 Diabetes
Abstract People with type 1 diabetes (T1D) are disproportionately affected by cardiovascular disease (CVD). CVD is a leading cause of death in T1D, contributing to 40% of mortality...