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606,025 grants found
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Depot formulations for on-demand tamper- and diversion-proof delivery of opioids
Summary Opioids are commonly prescribed for a variety of acute and chronic pain states. Unfortunately, prescribed opioids can be tampered with or diverted, both of which can have s...
Bayesian neurobehavioral phenotyping: from mechanism identification to personalized neuromodulation treatments
PROJECT SUMMARY Dysregulated activity within the neural networks that underlie reward and executive functions can increase vulnerability to compulsive drug use. Repetitive transcra...
Metabolic determinants of reactive astrogliosis and cognitive heterogeneity in aging
ABSTRACT The greatest risk factor for Alzheimer’s disease and related dementias (ADRD) is aging, but the mechanisms that link aging to ADRD disease processes are largely unknown. O...
Informal Caregiving Networks of Older Adults with Dementia
ABSTRACT In 2021, approximately 11 million Americans provided unpaid care to an adult with Alzheimer’s disease and related dementias (ADRD), which was estimated to be 16 billion ho...
Modulating blood flow and metabolism in Alzheimer's Disease models
ABSTRACT This project will develop and apply new intravital microscopy techniques to gain greater insight into the putative benefits effects of gamma entrainment, a promising nonph...
Understanding fertility trends in a cohesive high-fertility population within a low-fertility environment
Project Summary Western populations collectively responded to historically contingent, society-wide developments in the 19th and 20thcenturies by reducing births to record-low leve...
Airway compromise and skeletal muscle rigidity as toxicity contributors in synthetic opioid and methamphetamine co-administered rats
The United States is battling a drug overdose crisis fueled by deaths from the synthetic opioid fentanyl and from the neurostimulant methamphetamine. A better understanding of the...
Targeting miRNA-loaded exosomes to HNSCC with Dsg2-directed scFv fusion proteins
PROJECT SUMMARY/ABSTRACT Advances in immunotherapy, especially PD1/PD-L1 immune-checkpoint inhibitors (ICI), are revolutionizing the approach to personalized treatment for head and...
Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging
PROJECT SUMMARY Normal aging is associated with a gradual decline in cognitive abilities across the lifespan, which is accelerated by midlife vascular risk factors, including stiff...
Investigating the Role of Hepatic Glucagon Receptor Signaling in Healthspan and Aging
Project Summary: Obesity and type 2 diabetes mellitus accelerate aging shortening the duration of healthspan. Conversely, chronic calorie restriction extends healthspan. Most resea...
Population-level interventions and community environment effects on obesity among diverse Asian American ethnic subgroups
PROJECT SUMMARY Childhood obesity prevalence keeps rising, especially among school-age children, and varies by race/ethnicity. Children of origins in Asia and the Pacific Islands (...
Acetylated Tau Immunotherapy for Alzheimer's Disease
Abstract Alzheimer’s disease (AD) is one of the most common in the United States, as the sixth leading cause of death among those 65 or older, and impairing the quality of life for...
Feasibility of Electronic Screening to Identify Risk of Opioid Misuse and Overdose
Program Summary/Abstract From 1999–2020, more than 564,000 people died from an overdose involving any opioid, including prescription and illicit opioids. Despite the decades-long n...
Regenerative biomaterial for combating genitourinary syndrome of menopause
Project Summary Genitourinary syndrome of menopause (GSM) is an extremely prevalent condition consequent to the hypoestrogenic changes in the genitourinary tract that affects up to...
Functional consequences of the interactions between tau protein and opioids
PROJECT SUMMARY The opioid epidemic is a persistent public health crisis that has been worsened by the COVID19 pandemic. Efforts to curtail this epidemic have had minimal success i...
Gut clearance regulation and its subversion by Candida albicans
The CDC reports that fungal infections are responsible for ~9 million outpatient visits, ~75,000 hospitalizations and an estimated direct medical cost of ~$7 billion yearly. These...
Cardiovascular Risk Reduction for Adults with Food Insecurity Using Structured Incentives (CVD-FIT)
ABSTRACT Cardiovascular disease (CVD) is associated with significant morbidity and mortality, decreased quality of life, and increased health care utilization and cost. Food insecu...
Mechanisms underlying reversal of cardiac aging by urolithin a treatment
PROJECT SUMMARY/ABSTRACT Aging is one of the greatest risk factors for the development of cardiovascular disease and heart failure. Mitochondrial dysfunction in the aging heart is...
Using opioid industry documents to understand marketing of addictive medications
ABSTRACT Prescription opioids have been a key driver of the US opioid crisis, resulting in nearly 500,000 overdose deaths from 1999 to 2019. The US has the highest rate of per capi...
Investigating reciprocal interactions between circuit and synaptic function
PROJECT SUMMARY/ABSTRACT The patterns of connectivity across the neural networks of the brain play a critical role in determining how those networks function. However, the mechanis...