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606,025 grants found
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BREATH: Breakthrough Research in Electromyography for the Assessment of Sleep-disordered BreaTHing
Project Summary Abstract Objectives and Specific Aims: The overarching objective is to develop and validate a diagnostic tool for obstructive sleep apnea (OSA), Deep Learning-enhan...
SPF Rhesus Macaque Breeding Colony Expansion to Support HIV/AIDS-Related Research
PROJECT SUMMARY / ABSTRACT The Tulane National Primate Research Center (TNPRC) of Tulane University is one of seven National Primate Research Centers (NPRC) sponsored by the Nation...
Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation
Lung transplantation is increasingly used to treat an expanding list of end-stage lung diseases, resulting in an over >50% increase in the number of lung transplant procedures i...
Core A: Administrative Core
PROJECT SUMMARY – CORE A The goals of the Administrative Core, (Core A), are to provide coordination and integration of all Projects and Cores and within this Program Project Grant...
Core B: Human and Clinical Phenotyping Core
PROJECT SUMMARY CORE B Core B has the overarching goal of supporting the Scientific Projects by providing reliable and readily available clinical data from patients and will suppor...
Core C: Mouse and Cell Phenotyping Core
Core C has two overarching goals: (1) to provide reliable and technically consistent complex murine models of lung transplantation to identify pathways causally linked to primary g...
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction
PROJECT 1 SUMMARY Primary graft dysfunction (PGD) affects over 50% of recipients within the first 24-72 hours after lung transplantation. PGD is the dominant risk for post-operativ...
Physiologic and molecular mechanisms linking gastroesophageal reflux with chronic lung allograft dysfunction
The goal of this proposal is to elucidate physiologic mechanisms that promote gastric aspiration in lung transplant recipients and identify molecular mechanisms by which microaspir...
Crosstalk between profibrotic monocyte-derived macrophages and T cells in the pathobiology of CLAD
Project Summary: For many patients with advanced lung disease, lung transplantation remains the only viable therapeutic option to extend life. However, the 5-year survival for pati...
Mitochondrial integrated stress response and lung allograft dysfunction
PROJECT SUMMARY - ESI PROJECT Lung transplant outcomes are the worst among solid organ transplants in large part due to the nearly universal development of chronic lung allograft d...
Disease transmission along complex human-animal networks: a novel method for improving zoonotic disease modeling
ABSTRACT Endemic and emerging zoonoses both represent profound threats to public health. While these two disease systems diverge in many ways, fundamental to both is the importance...
Self-sealing needle guide system for reliable hemodialysis
PROJECT SUMMARY More than 500,000 Americans are living with end-stage kidney disease, and most of them require life- sustaining hemodialysis treatments three times a week. Despite...
Center for Circadian Rhythms and Alcohol-Induced Tissue Damage
ABSTRACT Fundamental unanswered questions in the field of alcohol research include: why do only a subset of individuals with an alcohol-use disorder develop clinically significant...
Modernization of high and maximum containment research facilities at the National Emerging Infectious Diseases Laboratories (NEIDL) to meet current and future national research priorities
PROJECT SUMMARY/ABSTRACT The National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University (BU) was established to generate essential information about new and re...
SJB Biomedical Research Center for Hispanic Health Disparities
PROJECT SUMMARY/ABSTRACT As an Institution of Emerging Excellence (IEE) in Puerto Rico, San Juan Bautista School of Medicine (SJB) is in critical need of new infrastructure to faci...
Fostering Ethical Adoption of Artificial Intelligence-Enabled Assistive Robots (AIAR) Grounded in Person-Centered Dementia Care
Project Summary/Abstract Dementia poses a significant challenge in the US, with one in three older adults living with the condition. This reality not only incurs staggering healthc...
Molecular Mechanisms of Hormone-Mediated Sex Differences in Wound Healing
PROJECT ABSTRACT Wounds have a sizable impact on public health: 1 out of 50 Americans has a chronic wound at any given time and the cost of wound care exceeds $100 billion per year...
Defining the molecular spectrum of white matter vascular lesions
This project will define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID).Cerebral small vessel disease (CSVD) i...
Targeting Interindividual Variability in NSAID Responses to Mitigate Chronic Pelvic Pain Risk in Dysmenorrhea
Menstrual pain (dysmenorrhea) is a major cause of distress, disability, and development of chronic pelvic pain (CPP). Very little is known about how local uterine inflammation and...
Natural Language Screening to Improve Early Recognition of Child Physical Abuse in Emergency Care Settings
PROJECT SUMMARY/ABSTRACT This project will test an innovative program of automated screening using natural language processing (NLP) to improve early recognition of child physical...