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606,025 grants found
Showing 24,941 – 24,960 of 606,025 grants
Understanding the developmental impact of environmental risk factors on brain and cognitive systems vulnerable to Alzheimers disease in children
Alzheimer's disease (AD) is a pressing issue in the United States, affecting over 6 million Americans and ranking as the fifth-leading cause of death in 2020 for persons 65 an...
Motor Skill Learning and the Development of Precise Neural Codes
PROJECT SUMMARY Motor skills that we learn early in life (e.g. talking or reaching) are essential to everyday function. Learning these motor skills involves building a repertoire o...
Alcohol metabolism potentiates HIV-induced lung and liver multimorbidity via inter-organ crosstalk
PROJECT SUMMARY/ABSTRACT Human immunodeficiency virus (HIV) / acquired immune deficiency syndrome (AIDS) remains one of the most critical public health problems in the 21st century...
Comparing pain phenotypes across lower back, knee, and TMJ
Abstract This research project aims to compare multi-domain pain phenotypes across various pain conditions, with a specific focus on the lower back, knee, and temporomandibular joi...
Local and Systemic Multi-Omics of TMJ Disorders
Project Summary/Abstract Temporomandibular Disorders (TMD) represent a spectrum of painful disorders that afflicts approximately 5 to 10% of the US population with approximate annu...
Improving Cancer Outcomes In Native American Communities (ICON)
OVERALL COMPONENT: PROJECT SUMMARY American Indian and Alaska Native (AI/AN) communities experience cancer incidence and mortality rates that are strikingly worse than those of the...
Improving Cancer Outcomes in Native American Communities (ICON) - Administrative Core
ADMINISTRATIVE CORE: PROJECT SUMMARY The Administrative Core (AC) provides the organizational nexus for the jointly conducted cancer research and career enhancement activities of t...
Improving Cancer Outcomes in Native American Communities (ICON) - Community Engagement Core
COMMUNITY ENGAGEMENT CORE: SUMMARY Community engagement is the foundation of our approach in ICON (the Improving Cancer Outcomes in Native American Communities U19 Center). Each of...
Water for Health: Strengthening Tribal Action for Cancer Prevention
PROJECT 2: WATER FOR HEALTH: PROJECT SUMMARY For decades, the Strong Heart Study (SHS) has collaborated with American Indian/Alaska Native (AI/AN) communities in the Northern Plain...
Lung Cancer Screening to Improve Equity in Tribal Communities in Oklahoma (Lung-Screen-Tribal OK)
PROJECT 2: OK-LUNG-SCAN OK: PROJECT SUMMARY Lung cancer is the leading cause of cancer mortality among American Indian and Alaska Native (AI/AN) populations, especially in rural Ok...
Care Coordination and Communication Program in Oncology for Tribal Health Systems
PROJECT 3: C3PO CARE COORDINATION: PROJECT SUMMARY Despite significant improvements in their overall health, AI/AN populations continue to face marked disparities in cancer outcome...
Multi-omic dissection of clonal hematopoiesis-associated diseases
Project Summary Self-renewing cell populations accumulate somatic mutations with aging and/or in response to environmental insult and chronic inflammation. Most of these mutations...
3D body shape analysis for predicting sarcopenia and obesity in older adults
Project Summary If successful, the proposed study will provide accessible and scalable methods with measurable and validated accuracy to assess key indicators of an older adult’s h...
Early Life Predictors of Airway to Lung Dysanapsis
PROJECT SUMMARY/ABSTRACT Chronic obstructive pulmonary disease (COPD) accounts for 6% of all deaths worldwide and is potentially preventable, with well-described but poorly elucida...
Driving lymphoid potential in multipotent hematopoietic progenitors by linker histones
Driving lymphoid potential in multipotent hematopoietic progenitors by linker histones Abstract Functionally impaired hematopoietic stem and progenitor cells (HSPCs) often display...
Multi-morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)
The overall goal of our proposal is to place patients impacted by Alzheimer’s Disease (AD) and Related Dementia (AD/ADRD), rather than the disease, at the center of the research in...
A Case-Cohort Study of Novel Determinants of Living Kidney Donor Risk
Living donor kidney transplantation is the best treatment for selected patients with end-stage kidney disease (ESKD). However, living kidney donation is not without medical consequ...
The role of transcriptional corepressor CtBP2 as a metabolic sensor in acute kidney injury
Project Summary Acute kidney injury (AKI) is a common and severe complication in hospitalized patients, which is associated with high morbidity and mortality rates. Patients who su...
Differential redox regulation of vein and arterial smooth muscle cells in AVF stenosis
(PLEASE KEEP IN WORD, DO NOT PDF)Kidney failure impacts many, with 750,000 cases annually in the US and 2 million globally. Treatment options include kidney transplant or dialysis....
Develop Autophagy Activators to Treat Autosomal Dominant Tubulointerstitial Kidney Disease
Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutations (ADTKD-UMOD) is one of the most common hereditary kidney diseases. It represents as many as 25%...