Browse All Grants
606,025 grants found
Showing 24,921 – 24,940 of 606,025 grants
Characterizing initial recovery from alcohol use disorder and predicting heavy drinking using mobile biosensors
PROJECT SUMMARY/ABSTRACT The overarching goal of this research project is to enhance the understanding and prediction of heavy drinking episodes during initial recovery (IR) from a...
Study of essential genes in Fusobacterium nucleatum
Project Summary: Fusobacterium nucleatum is a significant oral pathobiont associated with periodontal diseases. When it spreads beyond the oral cavity, it is strongly linked to var...
Effects of alcohol on bone remodeling balance in male and female non-human primates and humans
PROJECT SUMMARY Chronic heavy alcohol consumption contributes to high rates of low trauma fractures in middle-aged and elderly populations, especially men. However, low trauma frac...
Repopulation of the Microglia/Macrophage Niche in Experimental Lewy Body Disease
Lewy body disorders are a family of neurodegenerative conditions characterized by deposition of the abundant synapticprotein, α-synuclein, in insoluble cytosolic aggregates. The tw...
Develop a human-mouse chimeric brain model for studying tau pathology in human neuron in vivo
Project Summary/Abstract Alzheimer’s disease (AD) is the most common cause of dementia, affecting 6.7 million Americans aged 65 and older. Tau pathology, characterized by the abnor...
A Cluster-Randomized Control Trial of a Workplace Resilience Intervention for Child Care Providers' Mental Health & Well-Being
ABSTR ACT Work-related stressors take a heavy toll on individuals’ health and well-being as made even more evident by the increased awareness of essential workers during the pandem...
A bio-math approach to elucidate stem cell dynamics in Ceratopteris gametophytes
The development of multicellular organisms raises a key question: how are cell behaviors dynamically controlled to produce tissue and shape? Whether in plants, animals, or humans,...
Multisensory Processing of Alcohol Cues in Young Adult Binge Drinkers
Project Summary In 2022 approximately 61.2 million people aged 12 and older reported binge alcohol use in the past month and young adults ages 18 to 25 represent the highest propor...
Green Synthesis of Building Blocks and APIs by High Hydrostatic Pressure-initiated Synthesis
SUMMARY The current proposal is seeking funding to achieve the fundamental goal of systematically identifying processes that show promise during HHP activation. A broad range of re...
Never Again: Advancing the Prevention of Recurrent Child Sexual Abuse
Project Summary Child sexual abuse (CSA) is an adverse childhood experience with wide ranging effects on health, wellbeing, and development throughout the lifespan. The long-term g...
Dysregulated RNA metabolism in cell fate of maternal diabetes-induced neural tube defects
ABSTRACT Pregestational diabetes induces neural tube defects (NTDs), the second most common birth defects. We and others have shown that cellular stress, altered cell fate and epig...
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)
PROJECT SUMMARY Spontaneous intracerebral hemorrhage (sICH) survivors are at high risk for developing vascular contributions to cognitive impairment and dementia (VCID). However, t...
Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease
Summary: Substantial reductions in brain blood flow are found in patients with and mouse models of neurodegenerative diseases, including Alzheimer’s Disease (AD). Vascular patholog...
Daily Impact of Sexual Minority Stress on Alcohol-Related Intimate Partner Violence among Bisexual+ Young Adults: A Couples' Daily Diary Study
Project Summary/Abstract This study is guided by a long-term goal of optimizing alcohol-related intimate partner violence (IPV; psychological, physical, sexual, and identity abuse...
Alcohol and the skeletal muscle clock
Project Summary/Abstract Alcohol is a well-known myotoxin that with sustained use can culminate in alcohol-associated muscle disease (AAMD), characterized by muscle weakness and fu...
SCH: A multimodal wearable device to measure physiologic coupling
Acute exacerbations, bouts of disease worsening, are common in many chronic conditions like chronic obstructive pulmonary disease (COPD). These exacerbations have drastic impacts o...
SCH: Versatile and Compact Telerobot with Haptic Feedback and Physics-Informed Simulation for Safety Enhanced Neurovascular Interventions
Stroke is a leading cause of mortality and chronic disability, which predominately occurs due to blood clots or plaques impeding the blood flow in the brain (ischemic stroke) or a...
Trustworthy Machine Learning for Equitable Healthcare
Project Summary Infectious diseases, such as pulmonary tuberculosis and sepsis, are associated with significant patient mor- bidity and mortality. Because of their public health si...
2024 Epithelial Mesenchymal Transition (EMT) International Meeting
Abstract The specific aim of this proposal is to obtain partial funding for the expenses (travel and lodging) for junior investigators, postdoctoral fellows and graduate students f...
Alcohol-Induced End Organ Diseases Meetings
ABSTRACT Alcohol misuse is one of the leading preventable health risks globally, contributing to over 60 different diseases and injuries. The associated morbidity and mortality imp...