Browse All Grants
606,025 grants found
Showing 24,781 – 24,800 of 606,025 grants
Micro-capsule technology for high-throughput analyses of cell-cell interactions
Project Summary This proposal develops a novel technology to enable analysis of millions and eventually hundreds of millions of live cell-cell interactions in parallel. These tools...
Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypes
Project Summary/Abstract Spatial organization of the genome, nucleome and transcriptome is key to their control of many essential genomic and cellular functions. Yet existing tools...
Enhancing radioligand therapy for prostate cancer with biomarker and dosimetry guided personalization
ABSTRACT Radiopharmaceutical therapy (RPT) that delivers targeted cytotoxic radiation to cancer cells is typically administered on a fixed activity basis, without personalization,...
MiMA: Mother-infant Metabolite-transporter Atlas
ABSTRACT/SUMMARY The maternal-fetal/infant axis of transport represents one of, if not the highest duration and intimacy of long-distance communication across multi-tissue barriers...
Single Maintenance And Reliever Therapy Strategies for Implementation and Effectiveness Trial
Project Summary / Abstract Asthma is a leading cause of childhood morbidity and disparities nationwide and limited provider adoption of and patient adherence to the prevailing evid...
A Community-Based Approach for ALDH2 Genetic Testing in East Asian Americans
PROJECT SUMMARY Asian Americans are one of the fastest growing ethnic groups in the United States, yet they remain underrepresented in discussions about the utility of genetics and...
SKYSCAN 1276 CMOS in vivo microCT
The Small Animal Imaging Facility is a core research resource at the MaineHealth Institute for Research (formerly Maine Medical Center Research Institute). Currently, it consists o...
Adolescent Friendship Networks: Effects on Immigrant Youth’s Psychosocial Health
PROJECT ABSTRACT The proposed research will assess the impact adolescent friendship networks have on the psychosocial health of immigrant youth (i.e., the 1st and 2nd generation)....
The molecular mechanisms underlying context-specific Runx factor functions in directing hematopoietic cell identity
PROPOSAL SUMMARY/ABSTRACT My long-term career goal is to broaden our understandings of molecular and cellular mechanisms governing hematopoietic cell fate decisions both in normal...
Spatial Molecular Imager for Single Cell Imaging
PROJECT SUMMARY/ABSTRACT We are requesting funds for a NanoString CosMx Single Molecule Imager (SMI) to support spatial -omics in the Institute of Genomic Medicine (IGM) Genomics C...
Neural Circuitry Mechanisms Underlying Maladaptive Reward Memories in Drosophila
PROJECT SUMMARY: Alcohol addiction constitutes one of the most serious public health problems worldwide. According to the CDC, the total economic cost of excessive alcohol use is e...
Can Successful Early Childhood Interventions Sustain Impacts into Middle Childhood? A test from Kenya
Abstract An estimated 43 percent of children under age 5 in low- and middle-income countries (LMICs) will not reach their full developmental potential due to poverty, stunting, or...
The role of PHR signaling in tauopathy-related neurodegeneration
Project Summary Neurodegenerative diseases cause a progressive loss of neuronal function. Currently, an estimated 6 million Americans are live with dementia. Diagnosis often happen...
Myositis-ILD Risk Prediction Models and Endotypes
Interstitial lung disease (ILD) is a highly morbid and potentially fatal complication of myositis. Current myositis phenotypes do not capture significant heterogeneity in ILD clini...
Ultra High-Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer with UV-vis and Fluorescence Detection
Project Summary/Abstract: The Agilent 1290 Infinity Series II ultra-high-performance liquid chromatography (UHPLC) system with spectroscopic detection capabilities is a cutting-edg...
IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial
More than 300,000 surgical or endovascular lower extremity revascularization procedures are performed annually for Medicare beneficiaries who have lower extremity peripheral artery...
2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial
The IMPACT PAD Trial DCC Project Summary This U24 application from the Wake Forest University School of Medicine (WFUSM) describes plans by expe- rienced investigators and staff to...
The pulmonary immune response induced by single and multiple exposures to combustion products of burn pit constituents
Abstract Members of the Armed Services deployed in the Middle East were exposed to numerous environmental toxicants, including emissions from open-air burn pits. Burn pits are desi...
Multidisciplinary Characterization of the Gut-Brain Axis in Addiction
Project Summary Addiction and substance use disorders (SUDs) affect more than 27 million people in the United States, with an estimated $740 billion annual cost due to crime, lost...
Towards a comprehensive understanding of the neurotoxic spread of α-synuclein from gut to brain in Parkinson's disease
Parkinson’s disease (PD) is an age-related neurodegenerative disorder for which disease-modifying therapies do not currently exist and the underlying mechanisms remain incompletely...