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606,025 grants found
Showing 24,761 – 24,780 of 606,025 grants
Acquisition of disability and chronic morbidity by older Indians following extreme urban coastal flooding events
Project Summary Older populations in low and middle income countries are often highly dependent on children and other family members for their economic and physical wellbeing. Elde...
Investigating Feasibility and Acceptability of the FearLess Protocol for Patients with Primary Malignant Brain Tumors and Their Caregivers
PROJECT SUMMARY / ABSTRACT Fear of cancer recurrence (FCR) is alarmingly high among patients with primary malignant brain tumors, who face the certainty of tumor recurrence given t...
Evaluation of Impact of EHR Documentation Assistant Modalities on Provider and System Level Outcomes
Project Summary Over the past decade, there has been a growing epidemic of physician burnout, driven most notably, by Electronic Health Records (EHR), and the increasing amount of...
Investigating the physiological significance of follicular extracellular vesicle miRNAs: From gonadotropin control of biogenesis to application in oocyte vitrification
Project Summary As the average age of first-time mothers in the United States increases, the prevalence of assisted reproductive technologies (ARTs) including oocyte cryopreservati...
Genetically-encoded molecular imaging of genome-edited immune cells
Project Summary Adoptive cell transfers constitute a new paradigm in cell-based therapeutics with wide-ranging applications from neurodegenerative, cardiovascular, autoimmune disor...
Examination of the Role of Executive Function during Reading and Math in Children
Project Summary Abstract Children’s reading and math skills are critical to their future educational outcomes, career readiness, and overall health and well-being (e.g., ACT, 2020;...
Harnessing implementation science to study stress management for correctional officers in jail settings
PROJECT SUMMARY The purpose of this K01 Mentored Research Scientist Career Development award is to support Dr. Margaret Gorvine's current trajectory toward independent investi...
A smart wearable contact microphone patch for extended and remote monitoring of lung functions
Project Summary Respiratory diseases (RDs) like asthma and chronic obstructive pulmonary disease (COPD) are among the leading causes of death in the US and impose a major economic...
A Numerical Platform for Microbubble Enhanced Sonothrombolysis
Thrombosis is a leading cause of death and disability in the United States. While conventional treatment methods for thrombosis carry high-risks side effects, non-invasive ultrasou...
Develop natural compound emodin as a novel therapy for calcific aortic valve disease
Summary: Calcific aortic valve disease (CAVD) is a progressive heart disease ranging from aortic valve sclerosis to aortic valve stenosis, characterized by severe calcification wit...
Development of a high throughput in vivo screening platform for identifying novel pro-and postbiotic bacterial strains
Project Abstract Recent advances in metagenomic sampling have revealed the diversity of bacterial species in the human gut microbiome. Dysbiosis within the gut microbiome is a majo...
Precision imaging of electromechanical coupling for non-invasive cardiac arrhythmia mapping
PROJECT SUMMARY Cardiac arrhythmias are a major cause of morbidity and mortality affecting over 5% of Americans. Arrhythmias have become increasingly prevalent due to an aging popu...
Disease Mechanisms of Early Pulmonary Fibrosis
PROGRAM PROJECT SUMMARY To develop novel, transformative therapies that substantially reduce the burden of morbidity and mortality from progressive pulmonary fibrosis (PF), a funda...
Administrative Core
PROJECT SUMMARY Given the size, complexity, duration, and scope involved, the Administrative Core will be fundamental for enabling the successful establishment and operation of the...
Clinical Core
PROJECT SUMMARY The Clinical and Biospecimen Core (Core A) will support each Project in the Program by implementing all proposed studies involving human research participants. The...
Genomics Core
SUMMARY Single-cell/genomic technologies offer unprecedented opportunities to examine the cellular and molecular mechanisms of disease initiation and progression, predict disease d...
Project 1: Mechanisms of Early Disease Progression in FPF
PROJECT SUMMARY Although there has been substantial progress over the past decade in deciphering the pathobiology of progressive pulmonary fibrosis (PF), a large knowledge gap exis...
Project 3: Functional Genomic Mechanisms of Epithelial Dysfunction in Pulmonary Fibrosis
PROJECT SUMMARY Using single-cell RNA-sequencing (scRNA-seq), we and others have demonstrated dramatic changes in cellular identities, frequencies, and molecular programs that char...
Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis
PROJECT SUMMARY The advent of single cell RNA-sequencing (scRNA-seq) revolutionized our ability to study the molecular mechanisms underlying pulmonary fibrosis (PF). Our group has...
Project 2: Environmental exposures in pre-clinical FPF
PROJECT SUMMARY Pulmonary fibrosis (PF) is a progressive lung disease that typically presents in older adults who have moderately advanced disease and a limited life expectancy of...