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HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain.The...
Targeted, adaptive and time-variant strategies for bleed prevention across the lifespan for persons with hemophilia A
Project Summary/Abstract Options to reduce bleeding risk in persons living with hemophilia A are expanding. The issue is important because the expense of factor concentrates, the m...
Family-centered integration of social and medical care to promote health equity among children with asthma
Project Summary/Abstract: Asthma inequitably impacts under-resourced, Black, and Hispanic youth who experience higher asthma morbidity. These disparities are partially explained by...
Longitudinal changes in vascular and autonomic function in premenopausal women with PTSD
Project Summary The ultimate objective of this R03 proposal is to enable Dr. Ida Fonkoue to launch her independent research career by 1) expanding her current K01 research objectiv...
Inter-Generational Cardiometabolic Risk: Explore Underlying Immune Pathways
Abstract Despite decades of concerted efforts, the prevalence of obesity and its associated morbidities such as type 2 diabetes (T2D) and cardiovascular diseases (CVD) continue to...
Personalized Cancer Support for Young Adults
PROJECT SUMMARY Worry and distress in cancer survivors are common, do not correlate with disease severity, and are heightened in young adults who are going through multiple life tr...
XFIT: An Exercise-based Frailty Intervention in Lung Transplant Candidates
PROJECT ABSTRACT Despite major advances in risk stratification and clinical management, the field of lung transplantation continues to experience persistently high waitlist mortali...
Development of diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain
Project Summary/Abstract Myofascial pain remains an underdiagnosed contributor to a range of musculoskeletal pain conditions. The lack of validated biomarkers limits the ability to...
Integrated spatial omics to elucidate conserved inflammatory mechanisms of vesicant-induced skin injury
SUMMARY Despite significant research and investment, no FDA approved broad spectrum countermeasures are available to rapidly mitigate vesicant-induced injury following intentional...
Novel Biologics to ablate choroid plexus for the treatment of neonatal hydrocephalus
Project Summary Surgical treatment via ventriculoperitoneal shunt or endoscopic 3rd ventriculostomy is currently the most commonly used strategy to treat pediatric hydrocephalus. H...
Uncovering mechanisms of protection from Alzheimer's disease in CHIP using human cohorts and biosamples
Project Summary Aging is associated with outgrowths of mutated blood stem cells, termed clonal hematopoiesis of indeterminate potential (CHIP). The most frequent lesions in CHIP in...
Virtual Mindful After Cancer Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors
PROJECT SUMMARY Sexual concerns are among the most common, distressing, and persistent aspects of life after cancer. For at least half of breast and gynecological cancer survivors,...
Epidemiology and Long-Term Effect of Cardiometabolic Medication Substitution during Post-acute Care
PROJECT SUMMARY/ABSTRACT Nearly 70% of older adults experience medication discrepancy–inconsistencies in medication regimens when they transition from acute hospital to skilled nur...
Ohio State University Wexner Medical Center R25 Neurological Surgery Resident Research Training Program
ABSTRACT Over 1 billion people around the world will be significantly impacted by a neurological disorder during their lifetime. Better understanding of the underlying pathobiologi...
The Impact of Music Medicine on Preterm Brain Development and Behavior
PROJECT SUMMARY / ABSTRACT Very preterm survivors continue to experience high rates of neurodevelopmental impairment (up to ~60%) after discharge from the neonatal intensive care u...