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606,025 grants found
Showing 24,681 – 24,700 of 606,025 grants
Perturbation-response approaches to determining the regulatory networks underlying human complex traits
Project Summary/Abstract A large majority of heritable human traits and diseases are complex, with genetic variants of small effect spread throughout the genome. It is now understo...
Neuronal and Bacterial Driven Inflammation of the Dental Pulp in Molar Hypomineralization
Project Summary Molar hypomineralization (MH) is a prevalent enamel defect affecting 15% of children worldwide and is characterized by soft and porous demarcated opacities on the e...
Gene Therapy for MPS IV A in a Novel Porcine Model of the Disease
Project Summary This project centers on addressing the challenges posed by MPS IV A, a rare lysosomal storage disease caused by a deficiency in the GALNS enzyme due to mutations in...
VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid Angiopathy
Alzheimer’s disease (AD), most common form of dementia, affects over 55 million people worldwide. Numbers are expected to double every 20-years unless improved treatments are devel...
Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis
Cardiovascular disease has emerged as a significant contributor to cognitive impairment, operating both independently and as a catalyst for the progression of Alzheimer’s disease (...
Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Expansion of a hexanucleotide GGGGCC repeat within the first intron of the C9orf72 gene is the primary monogenic cause for both Amyotrophic Lateral Sclerosis (ALS) and Frontotempor...
Transspinal Magnetic Stimulation for the Treatment of Neuropathic Pain
ABSTRACT. Chronic pain ranks among the top reasons for seeking medical attention. Spinal Cord Stimulation (SCS) has been a traditional approach for managing chronic neuropathic pai...
Generation of intersectional genetic tools for advancing tendon and musculoskeletal research
Project Summary Tendon and ligament injuries are widespread and affect young active to aging individuals. Once injured, tendons undergo slow and limited healing and never regain th...
Talking with Small Molecules: Corynebacteria in the Human Microbiome
Project Summary & Abstract Bacteria communicate with their environment using a chemical language consisting of secreted small molecules, also referred to as natural products or...
Civil-military innovation platform (SYNERGIA)
Purpose and goal:The aim of the project is to develop a model and strategy to create a national innovation infrastructure that integrates civilian and military actors. This include...
Infrastructure for Civil-Military Synergies - Ideon
Purpose and goal:The purpose of this project is to develop a national infrastructure for civil-military innovation, enhancing collaboration between civilian and military actors in...
Demand Acceleration for civil-military synergies
Purpose and goal:The project aims to explore the hypothesis that working together with FMV, based on the framework for Demand Acceleration, could in the long term complement other,...
Civil-Military Synergies in Applied AI - CiMistAI
Purpose and goal:To plan a platform for civil-military innovation in applied AI, and to share the results of this work in the form of a report to VInnova and other stakeholders. Ex...
Infrastructure for Civil-military synergies Nord
Purpose and goal:Arctic Business, with our regional and national partners, will give suggestions on how to create a national infrastructure of organizations with networks, resource...
Genomic Medicine Master's Degree Program for Medical Students
PROJECT SUMMARY/ABSTRACT Advances in human genomics are transforming the diagnosis, treatment and prevention of disease. However, there are too few clinical geneticists and genetic...
MUSC GI and Hepatology Medical Student Training Program
Abstract – MUSC Gastroenterology (GI) and Hepatology Medical Student Training Program There is currently a crisis in physician led research in academic medicine. The 2021 NIDDK Str...
Using gene expression to identify patients at high risk for late breast cancer recurrence
PROJECT SUMMARY Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have improved, recurrence-free survival has steadily increased,...
Completing Glial Cell Biology: A Historical perspective
Abstract The history of glial cells is neglected in comparison to that of neurons, and this holds true a decade after the first grant application. We can debate about the possible...
Brain Development in Down Syndrome during Fetal and Early Postnatal Ages
Abstract Down syndrome (DS), or trisomy 21, is the most common chromosomal disorder in newborns (about 1 in every 700 babies in the United States). Associated with numerous impairm...
Building and Validating Lifelong Self-Management Capacity with Advanced AI: MyMSMentor
PROJECT SUMMARY In 2018, 51.8% (129 million) of American adults had at least one chronic condition (e.g., diabetes, arthritis). The total cost of chronic conditions is $3.7 trillio...