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606,025 grants found
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The role of Huntingtin in endolysosomal trafficking and Huntington's disease pathogenesis
PROJECT SUMMARY With no effective treatments or cures, ageing-related neurodegenerative diseases (NDs) present a pressing threat to our society. Converging evidence links NDs to de...
Impact of longitudinal CMV viremia on opportunistic neuroinfections in advanced HIV disease
Project Summary I am an Assistant Professor in the Division of Infectious Diseases & International Medicine at the University of Minnesota. My long-term goal is to become an in...
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol use among PWH in Nairobi, Kenya
Project Summary. Sub-Saharan Africa is home to >70% of people with HIV (PWH) globally. It is also burdened with rising rates of tobacco use, high rates of unhealthy alcohol use,...
Development of an antibody-oligonucleotide conjugate for treatment of Head and Neck Squamous Cell Carcinoma
Abstract: In this Direct to Phase II SBIR application, miRecule proposes to develop MC-30 an Antibody RNA Conjugate (ARC), composed of the anti-EGFR antibody cetuximab conjugated t...
Diversity Supplement to Mechanisms Regulating Lung Injury and Early Lung Fibrosis
ABSTRACT The overall goal of this Program is to understand the role of MUC5B in establishing a vulnerable lung and the transition of a vulnerable lung to a lung characterized by pe...
ONE Biorepository: Comprehensive Integrated Biobanking Systems
PROJECT SUMMARY/ABSTRACT. As a Comprehensive Cancer Center with a mission to `understand, prevent and cure cancer', Roswell Park has long recognized the value of human biospec...
Molecular mechanisms of pituitary plasticity
The anterior pituitary functions as the endocrine core of the organism, regulating hormonal synthesis and secretion to effect adaption to changing metabolic and reproductive needs....
Innovative modeling of the biopsychosocial model in animals: Validation of outcomes for assessing emotional and cognitive domains affected by naturally-occurring chronic pain in dogs
PROJECT ABSTRACT Osteoarthritis (OA) is a major and growing public health problem that negatively impacts quality of life. The prevalence of painful arthritis in the U.S. likely ap...
Functional roles of the human microbiome and metabolome in oral cancer
SUMMARY Head and neck cancer (HNC) remains a lethal disease despite concerted efforts to improve its diagnosis and treatment. Although smoking, drinking, and HPV infection are clos...
Wingquist Laboratory: Digital Centre for Product Realisation
Purpose and goal:The project develops the laboratory´s role in a national infrastructure that unites civil and military innovation environments. By combining research challenges wi...
Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP)
Abstract: Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP) Disparities in healthcare quality and health outcomes for Black patients compared to White patien...
Neural basis underlying the impact of stress on sleep
PROJECT SUMMARY Stress is associated with insufficient sleep and poor quality sleep. In particular, fragmented non-rapid eye movement sleep (NREMs) due to frequent brief arousals (...
Role of the TE-cGAS-STING pathway in C9orf72-ALS/FTD pathogenesis
Neurodegenerative diseases are characterized by genomic instability, abnormal chromatin relaxation, and transposable element (TE) mobilization, which can harm neuronal function. Ho...
Cellular and molecular mechanisms of dendritic spine growth and stabilization in health and disease
Abstract One of the most remarkable properties of the brain is its ability to undergo adaptive modifications in response to changing environments. This experience-dependent plastic...
Discovery and therapeutic targeting non-coding RNAs in T1D- or T2D-associated atherosclerosis
Despite current therapies and prevention measures, individuals with type 1 diabetes (T1D) experience a disproportionately higher risk of cardiovascular events due to a more severe...
Advancing Next Generation CAR-T cells for Renal Cell Carcinoma
Project Summary/Abstract Renal Cell Carcinoma (RCC) accounts for approximately 90% of kidney cancers in adults. Despite the advancements made in cytokine, immune checkpoint, and ta...
CSF Oligomeric α-synuclein targeted nano scavengers as a Parkinson's disease theranostic
Project Summary The pathogenesis of Parkinson’s disease (PD) and related synucleinopathies such as dementia with Lewy bodies are characterized by progressive deposition Lewy bodies...
In vivo efficacy, safety and PK/PD analysis of SYN101, a first in class, immune cell targeted TGFb therapy for cancer patients
NCI SBIR Phase II Summary The immune checkpoint inhibitors (ICI) block a single immuno-suppressive pathway in cancer patients. However, across all cancers, less than 30% of patient...
Unraveling the Role of Clonal Hematopoiesis in Neurodegenerative Diseases
ABSTRACT Clonal hematopoiesis (CH) has been linked to an increased risk of cancer and cardiovascular diseases. However, its potential implications in various age-related conditions...
Preclinical Modeling of Neural Regulatory Networks in Baboon Epilepsy
PROJECT SUMMARY Genetic generalized epilepsies (GGE) are the major subtype of epilepsy syndromes, accounting for about 40% of U.S. cases. Contrary to popular belief, over one-third...