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606,025 grants found
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Human Craniosynostosis Atlas (HuCA) : Standardizing & Establishing a Public Repository for Genomic and Imaging data
R21: Human Craniosynostosis Atlas (HuCA) : Standardizing & Establishing a Public Repository for Genomic and Imaging data. Project Abstract: Craniosynostosis is a premature fusi...
Clinic-Community Bridge-to-Care Initiative: Trauma and Violence Informed Care (TVIC) with Women Survivors of Intimate Partner Violence (IPV) and Living with HIV/AIDS
Abstract Johns Hopkins John G. Bartlett Specialty Practice (JGBSP) and Johns Hopkins HIV Women's Health Program (JHHWHP) provides comprehensive HIV care and treatment to women...
Commercialization of a Behavioral Digital Health Program for Individuals with Chronic Pain
2Morrow, Inc. CRP Grant Application – Project Summary: Chronic pain affects roughly 1 in 5 adults. Managing chronic pain is complex, and the reality for most patients is that livin...
Dynamic collagen architecture influence on mechanics of dystrophic skeletal muscle
Fibrosis, which is the pathologic accumulation of extracellular matrix (ECM), is one of the main traits of Duchenne muscular dystrophy (DMD) and many other muscle pathologies. Fibr...
Hermanas de Corazón: A Community Health Worker Initiative for improving Heart Health in Migrant Latina Farmworker Women
ABSTRACT Cardiovascular disease (CVD) is the leading cause of death of U.S. women with CVD mortality increasing in reproductive-age women. Rural, migrant Latina farmworker women ha...
Advancing Equity in Rare Disease Genomics
Project Summary Genomic research presents a unique opportunity for molecular diagnosis of individuals with rare disease, which may empower precision therapies to alleviate the indi...
Patterning Mechanisms for Ventricular Septation and Congenital Heart Disease
PROJECT SUMMARY The most common congenital heart disease (CHD) in children involves incomplete formation of the interventricular septum (IVS), which occurs in isolation or as part...
Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes
Project Summary—Abstract Healing following rotator cuff repair (RCR) remains a significant clinical challenge. While most patients report improvements in clinical outcomes, approxi...
Efficacy of a culturally-sensitive telehealth platform in fostering community-based care coordination for respectful maternal mental health
Project Summary The United States spends more money per capita on maternal and child healthcare than any other industrialized nation, yet maternal and fetal mortality rates are inc...
A Spatially Uniform Illumination Source for Widefield Multi-Spectral Optical Imaging
Project Summary The main objective of this proposal is to develop a new multi-spectral light source with exceptional illumination uniformity we call “Effective Uniform Color-Light...
Mechanisms of paired vagus nerve stimulation in human chronic stroke
After stroke, upper extremity (UE) motor impairment is especially disabling and has few effective therapies. Vagus nerve stimulation paired with rehabilitation training (paired VNS...
Exploring the unknown function of LRRC55 in pain
SUMMARY The opioid pandemic highlights the urgent needs to understand pain mechanisms and identify novel, non-opioid therapeutic targets to treat pain. Ion channels involve in almo...
Pediatric acute lymphoblastic leukemia: Improving outcomes through incorporation of novel targeted therapies into treatment for relapsed and newly diagnosed disease
O’Brien R50 Research Specialist (Clinician Scientist) Project Summary/Abstract While many children with acute lymphoblastic leukemia (ALL) are cured with frontline therapy, for tho...
Education Modules to Boost DiveRsity And InCrease Equity in Genomics (EMBRACE Genomics)
Project Summary Genetics and genomics have become increasingly important in research and medicine. Moreover, with core tenets valuing variation, genetics and genomics must lead in...
MetaboCore: Needle biopsy assay of drug sensitivity for solid tumors.
Abstract The goal of personalized oncology is to select the most appropriate drug(s) for individual cancers. A number of platforms (e.g., organoids and PDX mice) have been develope...
Trained immunity as a link between Inflammatory Arthritis and development of Cardiovascular Disease
SUMMARY Trained immunity describes the relatively new observation that exposure to inflammation alters the innate immune cells, monocytes and neutrophils, to alter their behavior s...
Gene Selection for Newborn Sequencing Studies
PROJECT SUMMARY/ABSTRACT The decreasing cost and increasing robustness of genomic sequencing technologies offer an exceptional opportunity to advance the future of newborn screenin...
The Role of Airway Epithelial Complement in Chronic Beryllium Disease
PROJECT SUMMARY/ABSTRACT Beryllium (Be) is used in several industries and the US is the largest exporter of Be in the world. Despite mitigation strategies, Be exposure at the workp...
PASK-regulated genes and proteins as therapeutic targets for ALS and FTD
Project Summary/Abstract Regulation of autophagy and the nutrient-sensing kinases mTOR and AMPK are not only important in cancer, but have garnered much recent attention in neurode...
Body heat activated, storable, near-infrared, self-illuminating nanoprobes for chemiluminescence imaging of cancer
PROJECT SUMMARY The main treatment of cancer is surgery, which has shown the best overall survival rate compared to radiotherapy and chemotherapy; but after the surgery, detection...