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606,025 grants found
Showing 24,481 – 24,500 of 606,025 grants
Development of selective GPR34 antagonists for the treatment of neuropathic pain
Neuropathic pain arises from nervous system injuries due to trauma, disease, or neurotoxin exposure afflicts15-20 million people in the U.S is very difficult to treat.1-6 Currently...
Developing small molecules to engage an analgesic GPCR in pain unpleasantness neural circuits
For millions of patients who suffer from a variety of painful conditions, opioid analgesics can provide decisive pain relief in part by decreasing the aversion normally associated...
Administrative Core
The Administrative Core (AC) will critically contribute to the success of this drug development project, “Developing small molecules to engage an analgesic GPCR in pain unpleasantn...
Data Management Core
The breadth and multidisciplinary nature of this project entails the generation, management, and analysis of numerous distinct data types and workflows. To address this need, the D...
Validation of Therapeutic Target and Underlying Biology
ABSTRACT Research Component (RC) 1 includes the validation of novel therapeutic targets for pain and the study of their biology. In our previous work, we discovered an ensemble of...
Development and Validation of Animal Models and/or Outcome Measures
ABSTRACT Research Component (RC) 2 includes the development and validation of novel animal models that model a specific pain type, and/or the development and validation of novel ou...
Archiving and Sharing Skeletal Phenotyping Data
Abstract Our objective is to build a data repository focused on collecting and sharing bone phenotyping data performed on rodent animal models. Over the last ten years, our group h...
Tooling for accurately studying the epigenome along the human pangenome reference
Project Summary/Abstract This proposal will provide the foundational tooling for understanding the function of the pan-genome reference through the accurate annotation of regulator...
Multimodal dendrimer theranostics targeting aggressive subtypes of prostate cancer
PROJECT SUMMARY Our ultimate goal is to develop a practical, theranostic platform for managing PC. Prostate cancer (PC) is the second most common cancer and the fifth most frequent...
State-transition and leukemia potential dynamics to inform disease evolution and adaptive therapy
PROJECT SUMMARY Acute myeloid leukemia (AML) is a group of aggressive and highly heterogeneous malignancies with poor overall survival. Despite advances in identification of molecu...
Building Tools and Community to Make Pangenomes Accessible
PROJECT ABSTRACT The human pangenome encompasses global genetic diversity missing from any single reference genome. This project will develop sequence alignment, population genetic...
Hydrolysis-resistant resin networks for durable and multifunctional dental restorations
Summary: The short average service life and the rising incidence of secondary caries currently hamper the reliability of existing dental composite restorations. This underlines the...
Unveiling the impacts of vapor pressure deficit on forest productivity
Atmospheric dryness, which is often quantified as a vapor pressure deficit (VPD), exerts significant influences on vegetation productivity and global carbon cycles.VPD is expected...
Unravelling the mechanisms of resistance to the macrocyclic lactones in the sheep scab mite, Psoroptes ovis
Abstracts are not currently available in GtR for all funded research.This is normally because the abstract was not required at the time of proposal submission, but may be because i...
Multimodal intraoral camera
ABSTRACT The WHO Global Oral Health Status Report (2022) estimated that oral diseases affect close to $3.5 billion people worldwide. Dental caries and cracks are two common dental...
Heavy metals exposure regulates secretory lineage in intestinal injury
PROJECT SUMMARY Over 160,000 abandoned mine waste sites are concentrated in the western United States and continue to degrade the environment with elevated heavy metals penetrating...
A novel long-acting conjugate of the vasodilative hormone, human brain natriuretic peptide (hBNP), to treat resistant hypertension
SUMMARY Hypertension affects one-third of US adults (68-88 million cases), contributing to >500,000 deaths per year and healthcare expenses of $51-131 billion annually. Despite...
A Novel Peptide for the Oral Treatment and Prevention of P. Gingivalis Infection
Project Summary Our goal is to develop a first-in-class oral peptide inhibitor for the treatment and prevention of gingivitis and periodontitis. Oral infection by P. gingivalis lea...
Exa-scale tissue readout methods
PROJECT ABSTRACT Our brain is the most complex system under study. It relies on precise wiring and signaling across billions of neurons. Our neurons span centimeters, communicating...
The Multisensory Ontogeny of Social Behavior
Project Summary In many mammalian species, infants rely on parental caregiving to survive the vulnerable phase of early development. Considerable evidence indicates that infants ar...