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606,025 grants found
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Novel fibril-selective nanobody-based agents targeting intracellular and extracellular α-synuclein aggregates and prion-like propagation induced dementia
Summary Lewy Body Dementias (LBDs) are a series of neurodegenerative disorders characterized by accumulation of misfolded α‐synuclein (αS), including Dementia with Lewy Body (DLB),...
Mechanisms of Islet Failure in CF
PROJECT SUMMARY Diabetes is a major co-morbidity of cystic fibrosis (CF), affecting 20% of adolescents and 40-50% of adults with CF. CF-related diabetes (CFRD) is associated with w...
Couple-based prenatal contraceptive education program for economically marginalized families
Project Summary/Abstract Economically marginalized individuals face multiple barriers to consistent desired contraceptive use. Inconsistent contraceptive use in the postpartum peri...
MSPP NIH MD/PhD Funding Application
Not Applicable no Abstract
Optimizing the Assessment of Parenting: A Multi-Method and Multi-Informant Approach
PROJECT SUMMARY Parenting plays a crucial role in youth development, influencing a myriad of health behaviors. As a result, parenting is a common focus of interventions aimed at im...
Towards Foundational 3D In Silico Models of Whole Mouse Embryogenesis
PROJECT SUMMARY A decade ago, with the advent of next-generation sequencing of the human pathogen Mycoplasma genitalium, Karr et al. reported the first whole-cell model that synthe...
Place-Based Influences on Mortality among People Experiencing Homelessness
PROJECT SUMMARY/ABSTRACT Research Challenge: More than 582,000 people in the US experience homelessness each night, and a staggering 1.25 million people enter the shelter system ea...
Development and application of machine learning-based approaches for estimating disease risk in diverse and admixed populations.
ABSTRACT Polygenic Risk Scores (PRS) quantify the genetic component of an individual’s risk of eventually developing a particular phenotype (generally a complex disease). They, alo...
Make an OFERR: Optimization for Enhanced RNA Replication
PROJECT SUMMARY Self-amplifying RNAs (saRNAs) are derived from single-stranded RNA (ssRNA) viruses, with the genes for the viral structural proteins removed and replaced with a gen...
Torch Recon: An Innovative Reconstruction Software for Increased Throughput and Improved Low-Count Quantitative SPECT Imaging
PROJECT SUMMARY/ABSTRACT Single-photon emission computed tomography (SPECT) imaging plays a pivotal role in radiopharmaceutical therapy (RPT), allowing clinicians to personalize pr...
Understanding data-driven models for neural dynamics
Project Summary/Abstract Recent technical advances have enabled to record the activity of hundreds or thousands of neurons simulta- neously. To extract insight from this deluge of...
Development of novel genetic medicine approaches to treat orphan diseases
SUMMARY: Adeno-associated viral (AAV) vectors hold great promise for treating genetic disorders. AAVs efficiently transduce tissues, including skeletal and cardiac muscles, which i...
Spatial Regulation of Epigenetic Memory
Project Abstract: Faithful epigenetic maintenance of repression is essential to developmental processes and is frequently disrupted in diseases like cancer. Repression is maintaine...
Neural control of rhythmic orofacial movements
Abstract Major efforts to understand how brain circuits activity gives rise to perception, mental experience, and behavior have broadly advanced our understanding of most of the ce...
BOUNCE: Development of a trauma-informed mHealth + peer support intervention to promote PrEP uptake among men who have sex with men
PROJECT SUMMARY/ABSTRACT HIV pre-exposure prophylaxis (PrEP) uptake has progressed slowly for gay, bisexual, and other men who have sex with men (MSM) in the United States, a popul...
Synthetic protein mimetics as potential therapeutics for Lewy Body Dementia
Currently, more than 55 million people have dementia worldwide and Lewy Body Dementia (LBD) makes up to 30% of all dementia cases.There are no therapies to cure or slow down/stop t...
Role of CHAMP1, a neurodevelopmental disorder high risk gene, in human brain development and function
PROJECT SUMMARY Nonsense or missense mutations of the CHAMP1 gene, which encodes for a zinc-finger protein involved in the maintenance of kinetochore-microtubule attachment during...
The anatomical and functional study of the thymus - defining the milestones of the thymic aging in the elderly human population
The concept of this program derives from our observations that the involution of the human thymus does not follow linear kinetics and is tailored to each individual. In most humans...
Steering the next generation of NCI-sponsored clinical trials in gastroesophageal cancers
Gastrointestinal cancers, and gastroesophageal adenocarcinomas in particular, are experiencing a clinical renaissance with the approval of recent biomarker-directed therapies. With...
Assay Development and Prognostic Model for Predicting Early Clinical Failure in Follicular Lymphoma
ABSTRACT Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL) subtype with a highly variable clinical course. While asymptomatic and low-tumor burden pat...