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606,025 grants found
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REACH Center Exposure Assessment Core
PROJECT SUMMARY - EXPOSURE ASSESSMENT CORE The REACH Center Exposure Assessment Core aims to provide expertise and services on big data use, exposure assessment, and statistical an...
Improving PGS Prediction for Underrepresented Groups Through Transfer Learning
In the last two decades, thousands of Genome-Wide Association Studies (GWAS) have been published. Increasingly, the findings reported by these studies inform the development of Pol...
Improving dog vaccinations: a development and feasibility study to pave the way for effective, synchronized dog vaccination campaigns in Africa
Title: Improving dog vaccinations: a development and feasibility study to pave the way for effective, synchronized dog vaccination campaigns in Africa Dog-mediated human rabies has...
Developing and Testing a Multilevel, Culturally Appropriate Lifestyle Intervention For Hispanic Patients with Metabolic-dysfunction Associated Steatotic Liver Disease
PROJECT SUMMARY/ABSTRACT Metabolic-dysfunction associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, is now one of the main risk factors...
Penn-DISAM: Data Integration and Statistical Analysis Methods for dGTEx Data
Abstract Our health and wellbeing prenatally and during the earlier years of life affect all future health and disease risks. This time period is the most sensitive for a child’s d...
CREBRF and risk of pregnancy and postpartum dysglycemia in American Samoan women
PROJECT SUMMARY As many as 42% of American Samoan women develop gestational diabetes (GDM) in pregnancy, which substantially elevates their risk of progressing to Type 2 diabetes (...
Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk Alleles
The endolysosomal/Golgi system provides routes for degradation or recycling of plasma membrane (PM) proteins via endocytosis and degradation of cytosolic proteins/organelles via au...
Regulating Skeletal Connectivity in Craniofacial Development and Disease
PROJECT SUMMARY The craniofacial skeleton is composed of multiple tissue types that must be precisely integrated during development to ensure normal structure and function. While t...
Targeted Realtime Assessment of Chronic Pain (TRAC-Pain) in Youth
Chronic MSK pain is marked by a complex biologic response accompanied by physiological perturbance in cognition, sleep, and energy levels (fatigue), and is associated with impairme...
Synchronizing Oscillatory Brain Activity to Treat Post-Stroke Aphasia
PROJECT SUMMARY/ABSTRACT Transcranial alternating current stimulation (tACS) is increasingly used to enhance perceptual and cognitive performance in healthy individuals and in indi...
Visualizing and Manipulating Neuronal ESCRT Dynamics in vivo
PROJECT SUMMARY The aim of this proposal is to elucidate how ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. ESCRT is a set...
The Role of KBTBD2 in Bone Development and SHORT Syndrome
PROJECT SUMMARY Childhood growth disorders have significant consequences in adult life, including body size, work and reproductive performance, and the risk of chronic diseases. Ou...
Thalmocortical interactions in taste perception
PROJECT SUMMARY Cortical taste responses reflect sensory stimulation, perception, and behavioral decisions. These responses are the result of interactions among several brain areas...
Molecular Signaling in Dentinogenesis and Dental Caries Risk
ABSTRACT Dental Caries is one of the most common chronic diseases worldwide, and one of the most understudied conditions in patients with rare diseases, critically undervalued in h...
Elucidating the mechanisms of ependymal ciliary signaling
ABSTRACT Ependymal motile cilia are responsible for the coordinated movement of cerebrospinal fluid (CSF) along the ventricle wall. The synchronized activity of ependymal cilia cre...
An Automated Virtual Reality Intervention to Enhance Firearm Safety Counseling in Pediatrics
PROJECT SUMMARY Studies have identified a lower fatality risk in households that secure their firearms locked and unloaded when compared to those where firearms are stored unlocked...
Algorithmic Analyses of Accelerometry Data to Capture Meaningful Upper Extremity Use and Recovery Following Distal Radius Fracture Repair
Project Summary/Abstract Distal radius fractures (DRF) are the most common upper extremity fracture. They disproportionately affect older women, and the overall incidence is increa...
Spatial Science Approaches to Enhance Gun Violence Surveillance and RelatedDeterminants
Project Summary/Abstract Gun violence in the United States continues to be a persistent and growing public health threat with over 100 fatalities per day. Furthermore, gun violence...
Investigating the therapeutic potential of maternal breast milk components for preterm white matter injury
SUMMARY White matter injury (WMI) is the most common type of brain injury in premature infants and is associated with adverse neurological outcomes, including motor and cognitive d...
Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia
Project Summary Although mild post-stroke aphasia is often disabling, there are no accepted treatments for this condition. Transcranial Magnetic Stimulation (TMS) in conjunction wi...