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606,025 grants found
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Development of a novel, RNA-interference-based therapeutic to treat prostate cancer
PROJECT SUMMARY Prostate cancer (PC) is the most common cancer in men, and the second leading cause of cancer death among men in the United States. There is a critical unmet need t...
Chest Tube with Sustained Release of Local Anesthetic Agents for Pain Reduction in Cardiothoracic Surgeries
Project Summary: Chest tubes are commonly implanted between the ribs and into the pleural space after cardiac surgery and during management of thoracic injury. While these devices...
Enhancing E. coli Nissle colonization with CRISPR-Cas immunity
Project Summary Inflammatory bowel disease (IBD) prevalence is rising globally and live biotherapeutic products (LBPs) have shown some success in relieving the symptoms of IBD. How...
Restoration of Neuromuscular Function Following Critical Nerve Gap Injuries
1 Abstract – More than 500,000 surgical procedures are performed annually in the United States to address 2 peripheral nerve injuries at a cost of more than $1.1B. Fewer than 50% o...
Development of a Novel Nectin Targeting Antibody-drug Conjugate for Ovarian Cancer Therapy
PROJECT SUMMARY/ABSTRACT Ovarian cancer is the most lethal gynecologic cancer with limited therapeutic options. Targeted cancer therapeutics, such as antibody-drug conjugates (ADCs...
Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer
Project Summary Genomic information is becoming increasingly vital across medical specialties, carrying the promise to revolutionize patient care. One major barrier to unlocking th...
Pioneering assays for spatially-resolved single-cell multiomics
Project Summary: Disease often stems from cellular dysfunction, and single-cell transcriptomics has been instrumental in unveiling the incredible diversity of cell types and advanc...
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology
Cognitive decline in the aging brain is driven by overlapping neurodegenerative and cerebrovascular pathologies.Over 80% of Alzheimer's disease (AD) patients co-present with c...
A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment
SUMMARY: Worldwide, up to 25% of premature infants born prior to 31 weeks gestation, and up to 50% of those born prior to 28 weeks gestation, have neurodevelopmental impairment (NI...
Community health worker implementation of transdiagnostic evidence-based treatment in Spanish: Advancing mental health equity for Latine parents
PROJECT SUMMARY/ABSTRACT This K08 proposal will address a critical need for evaluating and understanding the implementation of community health worker (CHW) mental health models to...
Dismantling barriers in pain management through an intersectional multi-method examination of race and gender biases
PROJECT SUMMARY The proposed Mentored Research Scientist Development Award (K01) will launch Dr. Mollie Ruben's program of research as an independent scientist focusing on ide...
Delineating Sources of Racial, Ethnic, and Socioeconomic Differences in the Diagnosis of Generalized Anxiety Disorder
PROJECT SUMMARY/ABSTRACT This K01 award will launch Dr. Kerry Kinney’s independent research career focused on reducing disparities in the diagnosis and treatment of generalized anx...
Neural Mechanisms of Colored Light Driven Analgeisa
Chronic musculoskeletal pain (cMSP), including fibromyalgia, affects over 14% of the population, is a leading cause of disability worldwide, and is often refractory to available tr...
Differential Impacts of Person and System Level Determinants of Health on Dyadic Heart Failure Management: The IMPACT-D Study
Heart failure (HF) is the fastest-growing cardiovascular disorder and a leading cause of urgent healthcare utilization in the U.S. Effective HF physical self-care (i.e. behaviors t...
Energetic metabolism in RASopathies as a novel therapeutic target
ABSTRACT RASopathies encompass a spectrum of genetic disorders caused by germline gain-of-function variants in genes encoding critical components of the RAS/MAPK pathway, leading t...
Regulation of connective tissue in the cell renewal of mature taste buds
Project Summary/Abstract Mammalian taste buds are a cluster of specialized epithelial cells residing primarily in the epithelium of the lingual taste papilla which covers a core of...
Psychometric Reliability and Validity for Behavioral Metrics of Osteoarthritic Pain in Horses
Project Summary Historically, osteoarthritis (OA) pathology is defined by the breakdown of articular cartilage. While cartilage loss remains a hallmark of OA, the pathology of OA i...
Development of an in vivo model system of sensory afferent neuron regeneration
Project Summary The afferent neurons of the eighth cranial nerve transmit information from the cochlea and vestibular organs to the brainstem. These neurons can be lost following d...
Explaining the potential role of physical activity in employment disparities after breast cancer
PROJECT SUMMARY Breast cancer is the most diagnosed cancer in the world with the largest survivorship group. The rise of breast cancer survivors (BCS) living longer, healthier live...
The effect of virtual reality-based food marketing on biological hunger signals and purchase intention in young adults
PROJECT SUMMARY This Mentored Research Scientist Development (K01) Award will support my long-term goal of becoming an independent investigator who specializes in examining the tec...