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606,025 grants found
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Advanced analytics for uncovering virus dynamics and functional potential
Project Summary/Abstract The human virome, i.e. the collection of viruses found in or on humans, is a complex set of viral communities whose diversity is only now starting to be ex...
Establishing laboratory methods for quantitative recovery of diverse DNA and RNA viral sequences from human biosamples
PROJECT SUMMARY The widespread adoption of inaccurate and biased methods has impeded effective analysis and stymied comprehensive understanding of the composition and dynamics of t...
Viral MEM: Viral Enrichment and Precise Stochastic Quantification with Microbial Context Preservation for Rigorous Virome Analysis of Challenging Human Samples
PROJECT SUMMARY Overview. This U01 proposal is dedicated to advancing the Human Virome Project (HVP) by addressing several key objectives outlined in RFA-RM-23-018 NOFO. The projec...
Interdisciplinary investigation of functional asymmetry and topological restructuring in mitochondrial networks during cellular aging
Project Summary Age- and function-based positioning of mitochondria plays a critical and conserved role in cellular differentiation and aging from yeast to humans. Evidence suggest...
Building Interdisciplinary Research Careers in Women's Health at UC Davis
PROJECT SUMMARY/ABSTRACT For this administrative supplement to our K12 BIRCWH grant, UC Davis is requesting support to allow our fourth Scholar, Dr. Adrienne Hoyt-Austin whose back...
Arkansas Bioinformatics Consortium
Project Summary/Abstract The Arkansas Research Alliance proposes to hold five annual workshops on the subject of bioinformatics. The purpose is to bring six major Arkansas institut...
Role of right ventricular passive remodeling in ventricular-arterial uncoupling in pulmonary hypertension
SUMMARY Right ventricular (RV) dysfunction and the inability of the RV contractility to keep up with increased afterload, or ventricular-arterial (V-A) uncoupling, in pulmonary hyp...
Endothelial Reactive Oxygen Species in Exercise Metabolism
PROJECT SUMMARY Exercise is a powerful strategy to improve skeletal muscle metabolism that can both prevent and reverse disease. However, the complex signaling that drives the imme...
Data Science Core
PROJECT SUMMARY - DATA SCIENCE CORE Significance: Effective climate change actions are hampered by a lack of transdisciplinary and community- informed data, fragmented health surve...
The Impacts of Adverse Provider Conditions on Provider Bias and Health Disparities
Project Summary Healthcare disparities that adversely affect patients from racial and ethnic minoritized groups are often attributed to provider level factors such as implicit bias...
The Heart Outcomes for Pregnancy Expectations Study
Project Abstract/Summary The US not only has the highest rate of maternal mortality in the developed world but is the only country in which this rate is rising. It is also notoriou...
Multicomponent mhealth interventions for healthcare providers and the community to increase cancer screening in India
PROJECT SUMMARY/ABSTRACT Given that a large proportion of cancers are detected at a late stage in India, approaches to increase screening uptake could have a significant impact on...
The impact of antiretroviral therapy on fetal immune system development in SIV-exposed rhesus macaques
SUMMARY The use of antiretroviral therapy (ART) in pregnant women living with HIV is an effective way to prevent mother-to-child transmission. However, HIV-exposed, but uninfected...
Development of tools for analyzing cell-cell communication using spatial transcriptomic data
PROJECT SUMMARY Biological tissues, consisting of different cells, specialize in a group of processes and functions through coordinated activities of many cells. Cell-cell communic...
Cultivating Recovery: A Pilot Study of Digital Contingency Management for Co-occurring Opioid and Alcohol Use Disorder
Project Summary/Abstract Opioid agonist therapies (i.e. buprenorphine and methadone) are first-line treatments for opioid use disorder (OUD) and overdose prevention. Sequalae of al...
3D Human neurocircuits to determine the role of microglia in AUD and Alzheimer's neuronal pathology
Abstract: 3D human neurocircuits to determine the role of microglia in AUD and Alzheimer’s neuronal pathology. Altered neuronal metabolism, neuronal activity, and neurodegeneration...
Human Trisome Project - Latin America Network
PROJECT SUMMARY. People with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display a unique clinical profile across the lifespan. Early on, children with DS...
The Infant Down Syndrome Brain and Behavior Study
ABSTRACT Down syndrome (DS), the most common genetic cause of intellectual disability, accounts for ~30% of all moderate-to-severe IDD cases, with ~5,500 new individuals diagnosed...
ConnectedNest: a digital platform connecting individuals with cancer to social care
SUMMARY ConnectedNest, a novel electronic social care referral platform developed by XanthosHealth, addresses the impact of social determinants of health (SDoH) on individuals faci...
Nourexal™: A Novel Bioenergetic Drug to Increase Donor Heart Utilization
PROJECT SUMMARY In the U.S., over 20,000 heart transplants are needed each year, but fewer than 4,000 procedures are performed despite the yearly availability of more than 12,000 d...