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Integrated multimodal phenotyping of zebrafish models of human cognitive disorders
Neurodevelopmental disorders often have clear genetic components but linking genotype to phenotype remains challenging. Recent advances in genome editing technology have enabled th...
AI-assisted Annotation of Minimally Invasive Surgical Video for Building Information-Rich Datasets and Data-Efficient Learning Systems
ABSTRACT Minimally invasive surgery (MIS) has gained popularity in recent years by offering increased manipulation dexter- ity in hard-to-reach areas through small incisions, there...
The role of placental macrophages in cytomegalovirus infection at the maternal-fetal interface
Human cytomegalovirus (HCMV) is the most common cause of congenital infection, affecting an estimated 0.6- 0.7% of newborns in the USA. Depending on the timing of maternal primary...
Asthma Self-Management Behaviors and Cognitive Autonomy: Developing an Adolescent Questionnaire
Background and Rationale: Asthma is a substantial public health problem with adolescents having substantial asthma-related morbidity. Adolescence is a critical phase of transition...
Improving Artificial Intelligence Readiness of RNA Motif Data for Structure Analysis and Modeling
PROJECT SUMMARY / ABSTRACT The rapid advancement of artificial intelligence (AI) and machine learning (ML) has led to significant breakthroughs in molecular structure modeling, par...
High-throughput optimization of gene editing systems for treating Amyotrophic lateral sclerosis
Project Summary Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurological disease in which motor neurons degenerate, thereby leading to paralysis and death due to res...
Metabolomics Workbench - National Metabolomics Data Repository
PROJECT SUMMARY/ABSTRACT The Metabolomics Workbench (MW) – National Metabolomics Data Repository (NMDR) is a unique data resource that serves the biomedical research community. It...
Integrating the reference pangenome with biobank-scale data for complex trait analysis
Project summary The human reference pangenome, which represents a collection of genome sequences in a single data structure, has the potential to transform human genetics applicati...
Exploring Best Communication Practices for Shared Decision Making in Older Adults Considering Major Colorectal Surgery
The older adult population (OAs; e.g., ≥65-years old) is projected to almost double between 2012 and 2050 in the United States. This population already disproportionately utilizes...
Investigating the regulation of the senescence-associated secretory phenotype (SASP) by mitochondrial DNA (mtDNA) metabolism for the development of novel senotherapies.
In response to various stresses such as DNA damage, telomere erosion, or oncogene activation, human cells can enter senescence.This process is characterized by irreversible prolife...
Targeting Amino Acid Metabolism in Glioblastoma
ABSTRACT Glioblastomas rank among the most lethal of all human cancers. Current therapy includes maximal surgical resection, followed by combined radiotherapy and oral chemotherapy...
The Caribbean Climate Change Adaptation, Cancer, and Health Disparities Research Center
Project Summary Overall Component Climate change is a threat to human health which impacts each step of the cancer control continuum. Frequent extreme weather events in the US Cari...
Administrative Core
Summary Administrative Core The Administrative Core (AC) of the Caribbean Climate Change Adaptation, Cancer, and Health Disparities Research Center (CCCARIB-CARES) will provide inf...
Research Project
RESEARCH PROJECT SUMMARY Climate change poses risks to human health through direct and indirect stressors. On tropical islands, some of the risks are accentuated. The population of...
Community Engagement Core
SUMMARY COMMUNITY ENGAGEMENT CORE As climate change impacts become increasingly visible in the US Caribbean (Puerto Rico [PR] and US Virgin Islands [USVI]), and adaptation measures...
Comparing a Novel Telehealth-enabled Hybrid Cardiac Rehabilitation Program to Clinic-based Cardiac Rehabilitation for Improving Patient Engagement, Functional Outcomes, and Health Equity after ACS
PROJECT ABSTRACT Cardiac rehabilitation (CR)—which involves exercise training, patient education, and health behavior modification—is a comprehensive intervention traditionally del...
Protecting endogenous recovery from the "infectious insult" in Spinal Cord Injury
Abstract Acquired infections after spinal cord injury (SCI) constitute the main cause of death in patients. For those that survive, acute pneumonia has been associated with signifi...
Social, Genomic, and Epigenomic Drivers of Clopidogrel Response in Puerto Ricans
Project Summary Pharmacogenomics has shown itself to be on the leading edge of clinical translatability in genomic medicine, with findings that are currently implemented across the...
Strategies to Improve Communication Structure and Quality in Low-resource Childhood Cancer Hospitals
PROJECT SUMMARY/ABSTRACT Children with cancer in low-resource settings face a survival rate of only 20%. Clinical deterioration, defined as the worsening of patient status that req...
Dance-based Avenues to Advance Nonpharmacologic treatment of Chemotherapy Effects (DAANCE): a multicenter trial
Project Abstract: Breast cancer (BC) is the second most frequently diagnosed cancer among women (second only to skin cancer)[11,12] and up to 80% of survivors experience chemothera...