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606,025 grants found
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Validation of a novel treatment for glioblastoma using oncolytic Zika virus
Project Summary / Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor with no known cure. GBM is projected to account for almost 14,500 new case...
Platform technology for targeted delivery of proteins to the intestines
Project Summary/Abstract Inflammatory bowel diseases (IBD) affect over 1.5M people in the US and despite the wide array of treatment options for maintaining remission in ulcerative...
Wearable Graphene Respiratory Sensor for Early Detection and Monitoring of Asthma
Project Summary / Abstract Asthma is a chronic, non-communicable disease that affects 300 million children and adults worldwide. In the United States alone, asthma burdens 26 milli...
Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV
ABSTRACT Tuberculosis (TB) is among the leading infectious killers worldwide with over 10 million new cases and 1.5 million deaths each year. Pulmonary TB, the most common form of...
RaceCAR-M immunotherapy for cancer and beyond
Cellular immunotherapies like Chimeric Antigen Receptor T cells (CAR-T) extend the lives of cancer patients who are otherwise out of options. These therapies represent a leap forwa...
Nuclear ATP citrate lyase and ischemia/reperfusion injury in steatotic liver
Abstract Non-alcoholic fatty liver disease represents a group of conditions associated with excessive lipid accumulation in hepatocytes because of long-term energy surplus. This di...
Understanding multilevel predictors affecting family formation among sexual and gender minority couples
PROJECT SUMMARY Family formation plans (e.g., whether/when to have children) vary by micro-level factors like sociodemographics (age, race/ethnicity) and individual- and couple-lev...
A Prospective Randomized Controlled Trial to Evaluate the Impact of Treatment of Asymptomatic Bacteriuria on Low Birth Weight
PROJECT SUMMARY/ABSTRACT Asymptomatic bacteriuria (AB) in pregnancy has been associated with an increased incidence of neonatal morbidity including preterm birth and low birth weig...
Determining the Proximal and Temporal Effects of Alcohol and Sexual Communication on Intimate Partner Sexual Violence among Sexual Minority and Heterosexual Couples
PROJECT ABSTRACT Up to 33% of women and 16% of men report experiencing intimate partner sexual violence (IPSV), and sexual minority (SM) individuals are 2.5 times more likely to ex...
ACCELERATE-BASSO: Coordinating Center for Accelerating Behavioral and Social Science through Ontology
ABSTRACT An individual’s phenotypes related to their health conditions are associated with the complex interplay between the individual’s biological, behavioral, social, and enviro...
Exploring genomic and cellular determinants of gene therapy durability
PROJECT SUMMARY Since the identification of disease-causing genes, the promise of gene correction seemed out of reach for decades. New delivery vehicles and gene-editing tools have...
Imaging deep-tissue morphogenesis at whole-organism scales
Project Summary/Abstract Morphogenesis of biological tissue is a rich and complex process in which coordinated interplay between molecular and mechanical stimuli progressively shap...
Actívatexto: Advancing smoking cessation and physical activity among Latinos
PROJECT SUMMARY Overcoming the burden of tobacco use among Latinos demands innovative, effective, accessible, culturally appropriate, and community-engaged solutions. Over the past...
Flexible dual-duration multi-wavelength fiber sources for nonlinear and multimodal imaging
The goal of this research program is to develop robust and flexible dual-duration, multi- wavelength fiber sources of light for nonlinear and multimodal imaging with orders of magn...
Cellular Mechanisms of Age-Associated Cortical Bone Remodeling
Abstract In the United States, 8.2 million women and 2.0 million men age 50 and above have osteoporosis. Moreover, half of all women and one quarter of men are projected to suffer...
Development of EP2 Receptor Antagonist to Treat Alzheimer's Disease
Lay Summary Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Currently, about 6.5 million Americans are living with AD. Alzheimer’s and other dementia...
The Development, Implementation, and Evaluation of a Social Engagement Support System
PROJECT SUMMARY Social drivers of health (SDoH) are the largest factors affecting our health and wellbeing but are difficult for healthcare systems to address. The lack of healthy...
Influence of Social Media, Social Networks, and Misinformation on Vaccine Acceptance Among Black and Latinx Individuals
Abstract One of the most recent and significant public health problems deals with addressing vaccine hesitancy and mis/disinformation. As new types of vaccines become effective and...
Promoting healthy interbirth intervals through post-partum reproductive health services
PROJECT SUMMARY The World Health Organization recommends postpartum family planning (PPFP) for birth spacing and prevention of maternal and newborn morbidity and mortality. Unfortu...
The EM-AD, a Novel Measure of Elder Mistreatment Among Dementia Family Caregivers
Project Summary/Abstract Over 1 in 10 older adults is the victim of elder mistreatment. Rates of mistreatment are even higher among older adults with dementia. Care of those with d...