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606,025 grants found
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Assessing Differential Dyadic Mechanisms of Black and White Women’s Sexual Functioning
Project Summary/Abstract Female sexual function (FSF) refers to how desire, arousal, orgasm, pain, pleasure, and satisfaction are experienced by women. Female sexual dysfunction (F...
Pathogenic exosomes during herpes zoster mediate increased vascular dementia risk
Project Summary: Vascular dementia is the second most common cause of dementia. Therapies aim to control risk factors (e.g. hypertension, hyperlipidemia, and diabetes mellitus) to...
Let's Talk: Overcoming barriers to the uptake of cascade screening through a stakeholder-informed online intervention
ABSTRACT The impact of genetic testing for disease prevention hinges on cascade screening, the process of systematically identifying and testing relatives in families with a geneti...
Leveraging Alcohol Use Disorder Screening for Treatment in Routine Perioperative Care: AllUsCare
Abstract Alcohol consumption adversely affects up to 28% of hospitalized patients and contributes to a loss of 133 million disability-adjusted life years and 5.3% of worldwide deat...
Mechanistic and Translational Investigations of HSPB8-associated dominant rimmed vacuolar myopathy
Mechanistic and Translational Investigations of HSPB8-associated dominant rimmed vacuolar myopathy. Autosomal dominant mutations in the heat shock protein family B member 8 (HSPB8)...
Development of POC system for patient condition and treatment monitoring in Sickle Cell Disease through hypoxia-induced sickling
PROJECT SUMMARY Functional Fluidics (FF) is developing a rapid integrated test for assessing RBC sickling based on hypoxia- induced changes in cell morphology as a potential indica...
Development of Novel Immunoregulatory Therapeutics for Asthma
Development of Novel Immunoregulatory Therapeutics for Asthma Biotherapeutics Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computati...
A Gamified Approach to Adolescent Alcohol Prevention that Strengthens Social Skills and Personal Values
ABSTRACT The goal of this Phase I SBIR project is to develop and test the prototype of an online alcohol prevention game appropriate for 13-15-year olds. The game emphasizes the pr...
EARLY CLINICAL DEVELOPMENT OF MODIFIED P8 FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EARLY CLINICAL DEVELOPMENT OF MODIFIED P8 FOR THE TREATMENT OF ALZHEIMER’S DISEASE SUMMARY: The pathological hallmarks of Alzheimer’s disease (AD) include the formation and accumul...
Hypoxically stored whole blood--evaluation of platelet activities under hypoxic storage conditions
Whole blood [WB] transfusion is an effective therapy used to reduce the large number of preventable deaths from hemorrhagic trauma. The long-term objective of this project is to de...
Novel oral small molecules for progressive pulmonary fibrosis
Abstract The overall goal of this program is the development and commercialization of a novel, safer, and more effective, therapy for the treatment of idiopathic pulmonary fibrosis...
Advanced Uricase Engineering for Improved Outcomes in Gout Patients
ABSTRACT Gout, a common form of arthritis triggered by high uric acid levels, affects a considerable patient population and the market for gout therapeutics is projected to grow si...
Developing an Elderly Patient-Specific, Accurate, Intuitive and Highly Interpretable System for Unconsciousness Management in General Anesthesia Using PASCALL FDA-Cleared Intraoperative EEG Monitor
Each day in the United States, over 100,000 patients receive general anesthesia, with about 40% being aged 60 and above. The current practice of general anesthesia is prone to over...
A Nanofluidic/Microfluidic System for Enhanced Low-Input and Single-Cell Proteomics
Within living cells, proteins are the primary cellular machinery, performing most biological functions. Aberrant protein expression or modification often leads to cellular dysfunct...
COMPASS: A Family-Centered, Culturally Responsive Conversational AI Assistant to Support ADRD Caregivers and Family Care Networks in Real-Time
Project Summary The majority of people living with dementia (PLWD) in the U.S. are cared for at home by family or friends without formal training. The challenges of providing ADRD...
Mg-based therapy for mitigating HAND and neuropsychiatric symptoms in the condition of chronic HIV infection
Abstract Microglia (Mg), the brain residential macrophage, play critical roles in maintaining adult brain homeostasis. Mg can function as multi-players such as housekeepers, guards...
Environmental Mutagenesis and Genomics Society (EMGS) Annual Meeting 2024-2028
The Environmental Mutagenesis and Genomics Society (EMGS) was founded in 1969 to provide a forum for the establishment and support of scientists in the field of environmental mutag...
1/2 Howard - Hopkins Comprehensive Alliance in Cancer Research, Education, and Equity (H2CAREE)
PROJECT SUMMARY In response to NIH PAR-23-308, the Howard-Johns Hopkins Comprehensive Alliance in Cancer Research, Education and Equity (H2CAREE) initiative aims to advance cancer...
2/2 Howard - Hopkins Comprehensive Alliance in Cancer Research, Education, and Equity (H2CAREE)
PROJECT SUMMARY In response to NIH PAR-23-308, the Howard-Johns Hopkins Comprehensive Alliance in Cancer Research, Education and Equity (H2CAREE) initiative aims to advance cancer...
DIRECTED DISCOVERY AND VALIDATION OF ANTI-SPLICE-JUNCTION SITE Abs
Abstract This Fast Track proposal's overarching goal is to develop a comprehensive platform for the identification and validation of recombinant antibodies (Abs) that are spec...