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606,025 grants found
Showing 24,161 – 24,180 of 606,025 grants
The role of vitamin K in knee osteoarthritis outcomes
PROJECT SUMMARY/ABSTRACT Despite the tremendous public health burden of OA, trials have largely been negative to date and there are no effective approved treatments that can preven...
User-friendly open-source pipeline for anatomically precise analysis of single-trial M/EEG
PROJECT SUMMARY Magneto- and electroencephalography (M/EEG) measure human brain activity non-invasively, using sensors placed on or above the head, with millisecond accuracy, and h...
Balancing Cellular Repair and Regeneration in Aging and Disease
PROJECT SUMMARY/ABSTRACT Background: Aging is an incredibly plastic process that is dictated by coordinated repair and regenerative mechanisms. Loss of this coordination marks the...
Drinking water salinity in a hot-dry environment: Hydration, kidney function, and blood pressure
PROJECT SUMMARY/ABSTRACT The increasing salinity of groundwater is a key emerging global environmental health risk factor for hundreds of millions of adults, including in the Unite...
Multi-Trait Analysis in Large-Scale Biobank Datasets Linked to Electronic Health Records.
PROJECT SUMMARY/ABSTRACT: Traditional genomic analyses like Genome-Wide Association Studies (GWAS) and Polygenic Scores (PGS) have greatly enhanced our knowledge of diseases, yet t...
DIALS: supporting structural biology through open source diffraction processing software
Project Summary/Abstract X-ray crystallography is a powerful tool for determining the atomic positions of proteins, used by researchers at synchrotrons and X-ray free electron lase...
X3DNA-DSSR: a resource for structural bioinformatics of nucleic acids
X3DNA-DSSR is a unique resource that excels in structural bioinformatics of nucleic acids. The proposed resource builds upon the features and large user base of 3DNA and DSSR enabl...
Dissecting the role of mPFC dynorphin circuits in the modulation of different pain states
PROJECT SUMMARY The goal of this work is to identify pain-induced adaptations in the prefrontal cortical dynorphin / kappa-opioid receptor system and the role this system plays in...
Investigation of cold plasma for healing alcohol-induced tissue injury
Abstract: Binge drinking of alcohol beverages hinders tissue repair and amplifies the susceptibility to infection. The prevalence as well as the risks associated with binge drinkin...
Development of a Culturally Adapted Digital Health Application for Older Hispanics with Type 2 Diabetes
PROJECT SUMMARY Poor health literacy, medication non-adherence, and lack of interventions easily delivered by healthcare providers negatively impact health outcomes in Hispanic pat...
Phase behavior of proteins in crowded environments
PROJECT SUMMARY Current research proposes protein phase separation as a key mechanism underlying the formation of liquid-like biomolecular condensates, which play an integral role...
Carver Genomic Research Center (CGRC)-Building Next Generation Genomic Data Scientist in Rural Alabama
Project Summary The establishment of a Diversity Center for Genomic Research at Tuskegee University is driven by a comprehensive objective: to advance, support and maintain researc...
Effects of Developmental Alcohol and Nicotine E-Cigarette Co-Exposure on Physiological Measures and Behavioral Development
PROJECT SUMMARY: Alcohol and nicotine are the two most commonly consumed licit drugs among pregnant people. Although the potential consequences of prenatal alcohol exposure at diff...
Engineering Chemically Modified RNPs for Effective Treatment of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder caused by the deficiency of the maternal UBE3A and characterized by severe developmental delay. Current treatment only helps manag...
UroMarker Test Panel for Obstructive Sleep Apnea
PROJECT SUMMARY PGXL Technologies is developing a patented, non-invasive urine-based assay for obstructive sleep apnea (OSA) in children. OSA occurs in up to 3% of children and as...
Daily & Localized NSAID Sonophoresis for Symptomatic Treatment of Knee Osteoarthritis
Project Summary: Arthritis is a significant economic and health burden in the United States which is estimated to exceed $394 billion in healthcare costs by 2030. Osteoarthritis (O...
Leveraging high-throughput functional data for assessment of Alzheimer's risk
PROJECT SUMMARY Alzheimer’s disease (AD) and AD-related dementias (ADRD) are irreversible, progressive brain disorders, and AD in particular is the sixth leading cause of death in...
TIBSA: A tailored interoperable guideline-based clinical decision-support system for asthma
Project Summary Asthma is a significant public health concern affecting the quality of life of over 8% of the US population and causing more than a million emergency department vis...
Chemically Induced Dimerization Systems for High Throughput Enzyme Assays
Abstract Enzymatic assays are critical for drug discovery: half of approved small molecule drugs inhibit enzymes, and enzymatic HTS (high throughput screening) assays are typically...
CTO1681 to prevent and mitigate cytokine release syndrome in CAR T-cell recipients
Abstract CytoAgents is developing CTO1681 for the prevention and treatment of cytokine release syndrome (CRS) associated with chimeric antigen receptor (CAR) T-cell therapy. CAR T-...