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The Impact of Discrimination on Anthropometric Outcomes: An Analysis of the Adolescent Brain Cognitive Development (ABCD) Study
Project Summary Obesity disparities in children and adolescents have persisted for decades. The reasons for these disparities are not fully understood, despite research into factor...
Adaptation and Implementation of SBIRT for Adolescents with Chronic Medical Conditions Hospitalized in Pediatric Inpatient Units
Title: Adaptation and Implementation of SBIRT for Adolescents with Chronic Medical Conditions Hospitalized in Pediatric Inpatient Units Project Summary/Abstract: Adolescents with a...
A Community-Driven, Health-First Approach to Climate Action and the Energy Transition
PROJECT SUMMARY - OVERALL The threat of climate change and urgency for large-scale preventive mitigation policies are now broadly recognized and supported by calls for a rapid and...
Admin Core
PROJECT SUMMARY - ADMINISTRATIVE CORE The overarching goal of the Health-First Climate Action Research Center, a Wisconsin-based Climate Change and Health Research Center (CCHRC),...
Project
PROJECT SUMMARY - PROJECT Urgent actions to address climate change are clearly needed, as climate threats to human health are extensive, formidable, and growing. Policies to reduce...
Community Engagement Core
PROJECT SUMMARY - COMMUNITY ENGAGEMENT CORE The Health-First Climate Action Research Center seeks to catalyze rigorous, innovative, community-driven, policy-relevant, interdiscipli...
Role of HIF-1 in intervertebral disc function
Our pioneering studies have shown that robust expression of HIF-1 allows NP cells to maintain their metabolism and bioenergetic needs in the hypoxic intervertebral disc. The applic...
Investigating single-T cell atopic gene networks in Asian and Hispanic genetic backgrounds
Investigating single-T cell atopic gene networks in Asian and Hispanic genetic backgrounds Project Summary/Narrative Immunomodulatory therapies now robustly improve atopic dermatit...
Mitigation of Highly pathogenic influenza (HPAI) in milk and dairy products
Project Summary/Abstract Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an emerging pathogen in dairy cattle with zoonotic potential. Recently, HPAI H5N1 spilled over into...
The role of the gut microbiota in alcohol seeking and decision-making
ABSTRACT The goal of this proposal is to investigate the role of the gut microbiota in alcohol seeking and reward-related decision-making. Alcohol is the leading risk factor for pr...
A user-customizable personalized normative feedback intervention for alcohol harm reduction in young adults: Feasibility, acceptability, and preliminary efficacy.
The proposed project entails (1) user-centered development of an innovative web-based intervention to reduce alcohol-related harm among young adults, and (2) pilot testing the inte...
Epigenetic aging as a driver of racial disparities in early onset prostate cancer
Prostate cancer (PrCa) shows significant racial disparities, especially impacting African American (AA) men, who have a 1.4 times higher risk of PrCa diagnosis, and a double risk o...
Adaptations and Impacts Understanding Teen Pregnancy Prevention Programs
Adaptations & IMpacts – Understanding Teen Pregnancy Prevention Programs (AIM-UP) Abstract: Adolescent pregnancies remain an area of marked health disparities, with significant...
Efficacy Testing of a Multi-Level Family Planning Intervention to Increase Contraceptive Use and Reduce Unintended Pregnancy in Low Resource Settings
Abstract In 2022, 29.7% of married women of reproductive age had an unmet need for family planning in Uganda, meaning they wanted to avoid pregnancy but were not using a modern con...
Cumulative Demographic and Health Effects of Climate Exposures
PROJECT SUMMARY This project will study how exposure to climatic variability (i.e., temperature and precipitation anomalies) during different phases of the life course, from early...
Development of CD4 TCR-engineered T cell immunotherapy in triple-negative breast cancer
Abstract Breast cancer is a leading cause of cancer-related deaths of women in the United States and worldwide. Immunotherapy is a promising approach, but has not proven successful...
Safety and Efficacy Trial of the ColoSeal ICD System for the Treatment of Rectal Cancer Patients
PROJECT SUMMARY/ABSTRACT Ostomy surgery for intestinal diseases are performed in around 130,000 patients annually in the US. Although currently fundamental to colorectal disease ca...
Creation of the Next Generation RNAi Therapeutics and an in vivo model for their study
Abstract RNA interference (RNAi) – a natural biological mechanism by which eukaryotic cells control gene expression – can be used to target and silence with high specificity virtua...
Ubiquitin pathway modulators for treating pancreatitis
New approaches are needed to treat acute and chronic pancreatitis which is a major health problem in the US. One novel approach is to promote mitochondrial health to protect pancre...
Norms re-education to promote engagement in parent-based interventions: A Type 1 implementation-effectiveness trial
Project Summary Underage drinking on college campuses remains a serious public health issue. Research suggests that Parent- Based Interventions (PBIs) that target parents of incomi...