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606,025 grants found
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The Human DNA virome: from petabase scale to single-cell resolution
PROJECT SUMMARY At the turn of the millennium, the cost of sequencing one megabase of DNA exceeded 10 million dollars. Today, decoding that same megabase costs less than a penny. T...
Mitigating the statistical bias due to anatomical variation in pediatric fNIRS
Title: Mitigating the statistical bias due to anatomical variation in pediatric fNIRS Abstract: Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging method...
Diversity Supplement for Rohda Yase
PROJECT SUMMARY/ABSTRACT The objective of this Diversity Supplement is to support an 18-month postbaccalaureate research experience for Rohda Yase. Ms. Yase is a bachelor’s degree...
A new platform for inexpensive and scalable recombinant protein and growth factor production to support cell culture applications in therapeutics.
Opera Bioscience proposes to develop a platform based on the type III secretion system of Salmonella enterica typhimurium, which transports proteins from the cytoplasm to the extra...
Close Relationships and Alcohol Use Disorder Risk
Project Summary/Abstract Models of alcohol use disorder (AUD) risk increasingly conceptualize relationship factors as being critical to theunderstanding of problem drinking. A subs...
The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis
While the contribution of exposure of future fathers (paternal) to environmental factors, such as smoking, to the pathogenesis of several disease states has been documented, that o...
Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI System
PROJECT SUMMARY Tyrosine kinase inhibitors (TKIs) are specified small-molecule inhibitors of the activity of tyrosine kinases and have shown therapeutic impact on treating cancers....
TIME-RESTRICTED FEEDING FOR PANCREATIC CANCER PREVENTION
The overarching goal of this Task Order is to determine the efficacy of time-restricted feeding (TRF) on PanIN prevention in a mouse model of pancreatic cancer and identify efficac...
The Colorado Building Interdisciplinary Research Careers in Women's Health Program
Project Summary This application is for the 4th cycle of funding for the Colorado Building Interdisciplinary Research Careers in Women’s Health Research (BIRCWH) K12 program, estab...
Task A02: Development of Small Animal Lassa Virus infection Model for the Assessment of Anti-Viral Activity of Medical Countermeasures Efficacy
This contract provides for the development of new and refinement of existing models of infectious diseases and may include evaluation of candidate countermeasures.
PrEDICT ADRD: Predicting the Effects of Diagnosis in Individuals across Countries and Time in ADRD
PROJECT SUMMARY / ABSTRACT As the overall prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease and related dementias (ADRD) grows, there is an urgent need to impro...
Overcoming tumor-intrinsic mechanisms of immune evasion to boost systemic response to radiotherapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint blockade has revolutionized the therapeutic landscape of patients with metastatic cancer. However, despite remarkable outcomes in some pa...
Concentration and single virion analysis of the virome
ABSTRACT Clinical virology is predicated on the workflow of analyzing small sample volumes (to minimize patient discomfort, storage, and fit legacy infrastructure) for a single ana...
Software-guided Operative Planning of MitraClip Placement
ABSTRACT Mitral regurgitation (MR) is the most common type of valvular heart disease in patients over age 75. Almost half of the patients identified with moderate-severe MR are not...
A novel mobile phone technology to improve access for preeclampsia and hypertension detection
Project Summary / Abstract Preeclampsia is a complication affecting 2 – 8% of all pregnancies and results in significant maternal and neonatal morbidity and mortality. The inventio...
Innovative Point-of-Care Solutions for Long-term Alcohol Biomarkers
In many countries risky drinking is common. Worldwide more than 5.1% of the overall global health burden is associated with alcohol misuse and this percentage is rising. Most of th...
Perceived Norms About Alcohol Use and HIV/STI Prevention among Adolescents and Young Adults in Rural Uganda
PROJECT SUMMARY/ABSTRACT Adolescents & young adults (AYA) accounted for >400,000 new HIV infections in 2021 worldwide. Heavy alcohol use is a prevalent and strong modifiable...
Next-Generation Cardiovascular Risk Assessments Via State-Of-The-Art Lipoprotein Characterization
Project Summary Electronic BioSciences, Inc. (EBS) proposes to develop an entirely new analytical testing device for the quantitative characterization of lipoprotein particles in b...
Partnering with Antenatal Navigators to Transform Health in Pregnancy (PATH)
PROJECT SUMMARY In the US, pervasive and insidious disparities in maternal health are urgent public health concerns. Social determinants of health (SDoH), such as poverty, exposure...
Elucidating novel mechanisms in the pathogenesis of Alport syndrome
PROJECT ABSTRACT Alport syndrome is the second most common cause of hereditary chronic kidney disease and is caused by mutations in the type IV collagen genes encoding 3, 4 and ...