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606,025 grants found
Showing 24,101 – 24,120 of 606,025 grants
Molecular architecture of the human knee joint and pelvis at single cell resolution
Project Summary/Abstract At the cornerstone of human bipedal locomotion are the pelvis and knee, two hind limb skeletal structures for which we know little about their respective d...
A framework for feasible translation to enhance foot and ankle function in aging and mobility
PROJECT SUMMARY / ABSTRACT This supplement will support Ms. Paula Kramer, a doctoral student from an underrepresented minority, to examine how new and modifiable targets to enhance...
Mechanisms driving muscle wasting and adipose tissue loss in the UBF mKO mouse
Project Summary/Abstract Skeletal muscle mass loss during cancer cachexia is one of the most important predictors of poor prognosis and mortality among cancer patients. However, th...
Tendon loading profiles that promote healing in Achilles tendinopathy
PROJECT SUMMARY Mid-substance Achilles tendinopathy is a painful, debilitating, and chronic tendon pathology. Rehabilitation exercises are the first treatment option for patients,...
Exposome Monitoring for Skin Diseases through Liquid Biopsy Multiomics
Project Summary Psoriasis and atopic dermatitis are common, immune-mediated skin diseases that are significantly influenced by environmental factors. Developing remote monitoring t...
Understanding the relationship between individual, social, and structural determinants of health, mobility, and HIV outcomes among adolescents and young adults living with HIV in Tennessee
ABSTRACT Adolescents and young adults living with HIV (AYA-HIV), especially minoritized individuals, face the highest HIV incidence and poorest care outcomes among all age groups o...
Measures of structural stigmatization and discrimination for HIV research with Latine sexual and gender minorities
PROJECT SUMMARY The goal of the proposed research is to develop, validate, and apply measures of state-level structural stigmatization and discrimination (SSD) for Latino/a/e (“Lat...
Molecular Basis for Altered Natural Killer Cells in Systemic Sclerosis associated-Interstitial Lung Disease
Cristina Padilla, MD NIAMS Diversity Supplement 2024-2026 The Molecular Basis of Altered Natural Kill Cells in Systemic Sclerosis-associated Interstitial Lung Disease Project Summa...
Decreasing Disparity in Lung Disease: Pulmonary Rehabilitation for Rural Patients with COPD
PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Globally, COPD prevalence is estimated to be 11.7%, and COPD i...
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)
Abstract The knowledge of the function, types, distributions, and plasticity of afferent neurites innervating temporomandibular joint (TMJ) tissues is needed to understand the unde...
Color's software and services platform for the Return of Personalized Value to the All of Us Research Program participants
ABSTRACT The All of Us Research Program (the Program) aims to accelerate health research and medical breakthroughs by engaging a diverse cohort of at least one million participants...
SELVA: A Multicenter, Phase 3 Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 in the Treatment of Microcystic Lymphatic Malformations
FOA Number: RFA-FD-23-001 FOA Title: Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required Proposal Title: SELVA: A Multicenter...
Convener and Organizer of Activities and Engagements Related to Processes, Surveillance, and Policy Development of Medical Products for Ongoing Public Health Activities, U01 Clinical Trial Not Allowed
PROJECT SUMMARY The Center for Drug Evaluation and Research (CDER) at the U.S. Food and Drug Administration's (FDA or the Agency) is seeking proposals for collaborative resear...
Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in Uganda
Project summary: In 2022, sub-Saharan Africa (SSA) had over 11 million Women living with HIV (WLWH), representing more than half (53%) of the region's total of 20.8 million pe...
Training in HIV Genomics, Treatment, and Cure Research in Botswana
ABSTRACT The goal of our parent D43 training grant is to provide training in research focused on HIV treatment, HIV cure, and HIV genomics research at the Botswana Harvard Health P...
Research Training on HIV Prevention and Treatment in Children and Adolescents
Project Summary There is a high prevalence of post-traumatic stress disorder (PTSD) and depression among women. These conditions are underdiagnosed and undertreated in Kenya and ha...
Functions of LynA and LynB kinases in dendritic-cell pro-inflammatory signaling and lupus
ABSTRACT The Src-family kinase Lyn is critical for maintaining immune homeostasis and protecting against autoimmunity, and deficits in Lyn function are linked to systemic lupus ery...
The role of cellular senescence in skeletal muscle loss and dysfunction
PROJECT SUMMARY/ABSTRACT The objectives of this proposal are to (1) obtain the experimental skills and career training necessary to develop a translational research program investi...
Senescent CAFs in Breast Cancer Progression
Cancer predominantly affects the elderly, with a significant incidence of breast cancer in women aged 50-70. While cell mutations contribute to tumorigenesis, age-related changes i...
Glutamine-driven "bidirectional" metabolism regulates muscle stem cell function
Abstract: Stem cell exhaustion and related metabolic dysfunction are hallmarks of aging, compromising tissue regeneration/renewal leading to eventual loss of tissue integrity and f...