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606,025 grants found
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Onco-immunologic factors contributing to OPSCC among people living with HIV
Oropharyngeal cancer (OPC) is a type of head and neck cancer and ~70% cases of OPC are associated with high-risk (hr) human papillomaviruses (HPV) infection. OPC cancers are increa...
Medical Scientist Training in the NIH Partnership Program - Yalan Wu
Not applicable
Uncovering the role of extracellular condensates as triggers of neuroinflammation
PROJECT SUMMARY Historically largely focused on the demise of neurons, a wealth of literature in the neurodegeneration field has provided strong evidence for a critical role of neu...
IND-enabling safety and toxicity testing of a subcutaneous formulation of the PTP1B inhibitor MSI-1436, a novel strategy for treating fatal cardiomyopathy in Duchenne muscular dystrophy patients
PROJECT SUMMARY Heart failure caused by progressive dilated cardiomyopathy is the primary cause of death in patients with Duchenne muscular dystrophy (DMD), a fatal inherited muscl...
Development of a Novel Aspiration Pump for Neurointerventional Procedures
ABSTRACT/PROJECT SUMMARY Strokes are the second leading cause of death worldwide. In the US they are the leading cause of disability, and cost the healthcare industry over $50 bill...
Bilateral Acoustic Sensing and Automated Breathing Segmentation for Remote Monitoring of Patients with COPD: A Longitudinal Study
Bilateral Acoustic Sensing and Automated Breathing Segmentation for Remote Monitoring of Patients with COPD: A Longitudinal Study Abstract: This SBIR Fast-Track project complies wi...
Targeted Exosomal Delivery of siRNA Therapeutics for Neuroinflammatory Diseases
Technical Abstract Neurodegenerative disorders affect over 40 million people worldwide and most, if not all, are mediated by inflammation. Even though several drugs have recently b...
Multiplex and multi-omic diagnostic test for bladder cancer recurrence
Following initial diagnosis and treatment, bladder cancer has a high recurrence rate, making it one of the most expensive cancers to treat over a patient’s lifetime. The current st...
Clinical evaluation of BMS-984923 metabolism.
SUMMARY/ABSTRACT This project seeks to develop a novel disease-modifying compound for AD (AD) by targeting the underlying mechanism of synapse loss. Synapse loss is tightly correla...
Informing Lifestyle Recommendations for Kidney Cancer Survival: Investigating the Role of Dietary Patterns and Physical (In)activity
PROJECT SUMMARY Renal cell carcinoma (RCC) accounts for 4.1% of new cancer cases in the United States (US) – 1 out of every 25 diagnoses – and the number of individuals living with...
Parental alcohol and cannabis before and during pregnancy: a pilot study
SUMMARY Alcohol is the most commonly used licit substance in pregnancy, and cannabis is the most commonly used illicit substance in pregnancy. Approximately half of pregnant people...
Proof of concept: diclofenac as a KMO inhibitor in AUD
Summary The development of efficacious medications for AUD remains a high research priority with current emphases on identifying novel molecular targets and efficiently screening n...
Developing and testing a measure of sociocultural norms related to interpregnancy intervals in African immigrants in the US.
PROJECT SUMMARY Despite the existence of guidelines from the World Health Organization and the American College of Obstetricians and Gynecologists recommending an optimal interpreg...
A Longitudinal Study of Egyptian Healthy Aging (Al-SEHA)
This project will implement A Longitudinal Study of Egyptian Healthy Aging (“AL-SEHA”) including the harmonized cognitive assessment protocol (HCAP) to measure the prevalence of Al...
Utility of human milk oligosaccharides against the perinatal pathogen, Group B Streptococcus
Project Summary Adverse pregnancy outcomes are a global issue that affects more than 50 million people per year. Infections during gestation contribute significantly to adverse pre...
Repurposing And/or Reactivating Disused Clinically Relevant Medical Therapies
Since humans first discovered that plants and biological extracts could be used to treat ailments, many thousands of assorted therapies have been developed to treat illness and dis...
Västervik Drone Science Park - Dual-use ecosystem
Purpose and goal:The project aims to develop a proposal for a concrete, realizable, scalable and replicable innovation/collaboration model for the dual-use ecosystem based on Väste...
CMILES: Civil Military Innovation & Leadership Ecosystems
Purpose and goal: This project aims to develop a blueprint and strategy for a national civil-military innovation infrastructure. The goal is to create a neutral, independent platfo...
Cell State Network-Directed Therapy
ABSTRACT—Cell State Network-Directed Therapy Drug resistance is a significant challenge in cancer therapy and has historically been addressed from “one step behind”, whereby drug(s...
Achilles Tendinopathy Center of Research Translation
ABSTRACT Current treatment strategies for Achilles tendinopathy seek to modulate the tendon mechanical environment to promote healing and regeneration. However, a lack of fundament...