Color's software and services platform for the Return of Personalized Value to the All of Us Research Program participants

ABSTRACT The All of Us Research Program (the Program) aims to accelerate health research and medical breakthroughs by engaging a diverse cohort of at least one million participants in the US. Color Health, Inc. (Color) is an organization that has been built to improve population health by providing best-in-class diagnostic testing, scalable clinical services,

and user-centered software tools. Over the past five years, Color has developed a custom return of results platform and provided high-quality clinical services as the Program’s Genetic Counseling Resource (GCR). To date, Color’s software and professional services have made results available to more than 240,000 All of Us

participants and completed more than 3,500 genetic counseling appointments. Here, we outline our proposal to continue to support the Program as it strives to reach its goals of recruiting and retaining one million engaged and diverse participants. In addition, we describe our technical approach and capabilities to ensure the success of the Program

as it tackles new partner integrations, enrolls new participant cohorts, and launches ancillary studies, all while maintaining its commitment to Return Value and Engage with its diverse participant base. Color's technical approach includes a robust software architecture for personalized result generation, participant return of results, and custom tools to support Program

coordination and clinical service delivery. To ensure ongoing Engagement, Color will develop a customizable notifications platform for tailored participant communication strategies. Our experience in software development, regulatory compliance, and participant-centric design ensures high-quality, scalable, and secure services, meeting

immediate Program needs and supporting future expansions, including new genomic results and other information types. In addition, Color will provide best-in-class professional genomics-specific support and genetic counseling services to the Program’s culturally diverse, geographically dispersed population, with multilingual support and accessible phone consultations. Our

culturally competent staff will deliver empathetic and appropriate services, addressing the unique needs of the Program’s participants. Finally, Color proposes to drive the longitudinal participant Engagement and Return of Value strategy by providing meaningful and personal information in a sensitive and

regulatorily compliant manner. This includes gathering and incorporating input from the diverse set of stakeholder opinions across Program Staff and partners. By ensuring that the Program is able to provide regular touchpoints and personalized insights, we aim to enhance the participant experience and drive long-term involvement.

Through these efforts, Color aims to advance the All of Us Research Program's ultimate goal to help individualize prevention, treatment, and care of patients, ensuring long-term success and contributing to groundbreaking health research.